Wood Development Group Institute of Biotecnology Viikinkaari 1 (P.O.Box 65)
00014 University of Helsinki
fax +358-9-1915 9366
Ykä (Yrjö) Helariutta
Plant Molecular Biology Lab
Date of Birth: January 13, 1965
Synopsis of the previous work and selected publications:
Helariutta Y, Elomaa P, Kotilainen M, Seppänen P, Teeri TH.
Cloning of cDNA coding for dihydroflavonol-4-reductase (DFR) and characterization of dfr expression in the corollas of Gerbera hybrida (Compositae).
Elomaa P, Honkanen J, Puska R, Seppänen P, Helariutta Y, Mehto M, Kotilainen M, Nevalainen L, Teeri TH.
Agrobacterium-mediated transfer of antisense chalcone synthase cDNA to Gerbera hybrida inhibits flower pigmentation.
Helariutta Y, Elomaa P, Kotilainen M, Griesbach RJ, Schroder J, Teeri TH.
Chalcone synthase-like genes active during corolla development are differentially expressed and encode enzymes with different catalytic properties in Gerbera hybrida (Asteraceae).
Helariutta Y, Kotilainen M, Elomaa P, Kalkkinen N, Bremer K, Teeri TH, Albert VA.
Duplication and functional divergence in the chalcone synthase gene family of Asteraceae: evolution with substrate change and catalytic simplification.
Eckermann S, Schröder G, Schmidt J, Strack D, Edrada RA, Helariutta Y, Elomaa P, Kotilainen M, Kilpeläinen I, Proksch P, Teeri TH, Schröder J.
New pathway to polyketides in plants.
Kotilainen M, Helariutta Y, Mehto M, Pollanen E, Albert VA, Elomaa P, Teeri TH.
GEG participates in the regulation of cell and organ shape during corolla and carpel development in gerbera hybrida.
- Philip Benfey lab (1995-1998): Between September 1995 and December 1998 I was as a post-doctoral fellow in the Philip Benfey lab (New York University). Since root development in Arabidopsis had become a model on organogenesis in plants, my post-doctoral focus was the genetic control of radial pattern formation during root development in Arabidopsis thaliana. I investigated two genes (SCARECROW, SCR, and SHORTROOT, SHR) that are essential for asymmetric cell division events during root development. I visited the Benfey lab after the classical screens for the short root mutants had been performed (Benfey et al.1994 Development. 1993 Sep;119(1):57-70; Scheres et al.1995 Development). I carried out a combined SCR expression (in situ) and mutant analysis during root development focusing on embryogenesis and found that SCR is critical for the spatial and temporal regulation of various asymmetric cell division events during plant development. My main contribution was the molecular cloning of the SHR gene that functions upstream of SCR in a cell-nonautonomous fashion, indicative of a novel, radial cell signaling scheme. I also participated in leading of a joint project between the Benfey lab and Prof. Victor Albert lab (New York Botanical Garden) on the molecular basis of diversity in root development in plants. We focused on the relationship between radial patterning and meristem organization using SCR as a marker for radial pattern information. An extensive developmental analysis of the expression of the putative SCR ortholog of maize was carried out.
Di Laurenzio L, Wysocka-Diller J, Malamy JE, Pysh L, Helariutta Y, Freshour G, Hahn MG, Feldmann KA, Benfey PN.
The SCARECROW gene regulates an asymmetric cell division that is essential for generating the radial organization of the Arabidopsis root.
Wysocka-Diller JW, Helariutta Y, Fukaki H, Malamy JE, Benfey PN.
Molecular analysis of SCARECROW function reveals a radial patterning mechanism common to root and shoot.
Helariutta Y, Fukaki H, Wysocka-Diller J, Nakajima K, Jung J, Sena G, Hauser MT, Benfey PN.
The SHORT-ROOT gene controls radial patterning of the Arabidopsis root through radial signaling.
Lim J, Helariutta Y, Specht CD, Jung J, Sims L, Bruce WB, Diehn S, Benfey PN.
Molecular analysis of the SCARECROW gene in maize reveals a common basis for radial patterning in diverse meristems.
- my lab (1999-): After my experiences in flower and root development, I initiated a research activity on wood development. I am grateful to Teemu, Phil and all the various other scientists representing many disciplines of science, with whom I have interacted and from whom I have learned a lot during these years while developing towards a more independent status and beyond! I also want to thank all the members of my lab for a successful and pleasant collaboration!
Mähönen AP, Bonke M, Kauppinen L, Riikonen M, Benfey PN, Helariutta Y.
A novel two-component hybrid molecule regulates vascular morphogenesis of the arabidopsis root.
Helariutta Y and Bhalerao R.
Bonke M, Thitamadee S, Mahonen AP, Hauser MT, Helariutta Y.
Higuchi M, Pischke MS, Mahonen AP, Miyawaki K, Hashimoto Y, Seki M, Kobayashi M, Shinozaki K, Kato T, Tabata S, Helariutta Y, Sussman MR, Kakimoto T.
Nieminen KM, Kauppinen L, Helariutta Y.
Bonke M, Tähtiharju S and Helariutta Y.
Carlsbecker A, Helariutta Y.
Mähönen AP, Bishopp A, Higuchi M, Nieminen KM, Kinoshita K, Törmäkangas K, Ikeda Y, Oka A, Kakimoto T, Helariutta Y.
Anthony Bishopp, Ari Pekka Mähönen and Ykä Helariutta
Some popular articles (in Finnish):
Helariutta Y, Kangasjärvi J, Teeri T. Mitä lituruoho antaa lääketieteelle?