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Pushing the frontiers of science to make a difference 

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We are interested in mechanisms of neurodegeneration, neuroinflammation, neurogenesis and neurotrophic factors and are focused on studying Parkinson’s disease and stroke. Drug therapies for neurodegeneration are still based on alleviating symptoms and the major challenge we have is to develop disease modifying therapies. We try to find new ways to stop neurodegeneration. 

STROKE

For ischemic brain injury we are focused on delayed events. Manipulations of these events can result in restoring damaged neuronal circuits. We are focused on neurotrophic factors, endoplasmic reticulum stress, and inflammation that occurs days after stroke.

PARKINSON'S DISEASE

In Parkinson's disease dopamine neurons, originating from substantia nigra, first lose their phenotype before they die. Our approach is to use novel neurotrophic factors to regenerate dopamine circuitry and slow down the progression of the disease.

NOVEL DRUG TARGETS

We are using in vivo animal models to find novel drug targets in various cell types such as microglia, astrocytes and neurons. We use epifluorescence, luciferase and colorimetric -based reporter assays to find ligands for novel drug targets.

STATE OF THE ART SERVICES

We can provide custom service research for academic groups, small and medium sized enterprises as well as the pharmaceutical industry.

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