Di-Poi Group

    Nicolas Di-Poi
    Group Leader
    Tel: +358-50-4160551
    Fax: +358-29-4159930
    Email: nicolas.di-poi -at- helsinki.fi

    Institute of Biotechnology
    Research Program in Developmental Biology
    P.O. Box 65
    00014 University of Helsinki

    Street address:
    Viikinkaari 1, Biocenter 3
    00710 Helsinki


croco eye science



Selected Publications

Da Silva, F.O., Fabre, A.C., Savriama, Y., Ollonen, J., Mahlow, K., Herrel, A., Müller, J. & Di-Poï, N. The ecological origins of snakes as revealed by skull evolution. Nature Communications 9(1):376 (2018). (Article)

Ollonen, J., Da Silva, F.O., Mahlow, K. & Di-Poï, N. Skull development, ossification pattern and adult shape in the emerging lizard model organism Pogona vitticeps: a comparative analysis with other squamates. Frontiers in Physiology 9:278 (2018). (Article)

van der Vos, W., Stein, K., Di-Poï, N. & Bickelmann, C. Ontogeny of Hemidactylus (Gekkota, Squamata) with emphasis on the limbs. Zoosystematics and Evolution 94(1): 195-209 (2018). (Article)

Di-Poï, N. & Milinkovitch, M.C. The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendages in amniotes. Science Advances 2(6): e1600708 (2016). (Article)

Di-Poï, N. & Milinkovitch, M.C. Scales and fur have shared origin. Nature 534(7609): 592 (2016). (Article)

Di-Poï, N. & Milinkovitch, M.C. Crocodilians evolved scattered multi-sensory micro-organs. EvoDevo 4(1): 19 (2013). (Article)

Milinkovitch, M.C., Manukyan, L., Debry, A., Di-Poï, N., Martin, S., Singh, D., Lambert, D. & Zwicker, M. Crocodile head scales are not developmental units but emerge from physical cracking. Science 339(6115): 78-81 (2013). (Article)

Di-Poï, N., Montoya-Burgos, J.I., Miller, H., Pourquié, O., Milinkovitch, M.C. & Duboule, D. Changes in Hox genes’ structure and function during the evolution of the squamate body plan. Nature 464(7285): 99-103 (2010).(Article)

Di-Poï, N. & Duboule, D. Hox genes key to diversity. Nature 464(7285): 5 (2010).

Di-Poï, N., Koch., U., Radtke, F., & Duboule, D. Additive and global functions of HoxA cluster genes in mesoderm derivatives. Developmental Biology 341(2): 488-498 (2010). (Article)

Di-Poï, N., Montoya-Burgos, J.I. & Duboule, D. Atypical relaxation of structural constraints in Hox gene clusters of the green anole lizard. Genome Research 19(4): 602-610 (2009). (Article)

Di-Poï, N., Montoya-Burgos, J.I., Miller, H., Denans, D., Pourquié, O., Milinkovitch, M.C., & Duboule, D. Atypical relaxation of structural constraints in Hox gene clusters of squamates. Mechanisms of Development 126: S250 (2009).

Di-Poï, N., Zakany, J. & Duboule, D. Distinct roles and regulations for Hoxd genes in metanephric kidney development. PLoS Genetics 3(12): e232 (2007). (Article)

Di-Poï, N., NG, C.Y., Tan, N.S., Yang, Z., Hemmings, B.A., Desvergne, B., Michalik, L. & Wahli, W. Epithelium-mesenchyme interactions control the activity of PPARbeta/delta during hair follicle development. Molecular and Cellular Biology 25(5): 1696-1712 (2005). (Article)

Di-Poï, N., Desvergne, B., Michalik, L. & Wahli, W. Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. Journal of Biological Chemistry 280(46): 38700-38710 (2005). (Article)

Yang, Z., Tschopp, O., Di-Poï, N., Bruder, E., Sürücü, B., Baudry, A., Dümmler, B., Fayard, E., Boguchi, A., Wahli, W. & Hemmings, B.A. Dosage-dependent effects of PKB alpha and PKB gamma on mouse skin, cardiovascular and nervous system development. Molecular and Cellular Biology 25(23): 10407-10418 (2005). (Article)

Wahli, W., Tan, N.S., Di-Poï, N., Desvergne, B. & Michalik, L. PPAR in cell survival and migration. Chemistry and Physics of Lipids 136(2): 87-88 (2005).

Tan, N.S., Michalik, L., Di-Poï, N., NG, C.Y., Mermod, N., Roberts, A.B., Desvergne, B. & Wahli, W. Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression. EMBO Journal 23(21): 4211-4221 (2004). (Article)

Di-Poï, N., Michalik, L, Desvergne, B. & Wahli, W. Functions of Peroxisome Proliferator-Activated Receptors (PPARs) in skin homeostasis. Lipids 39(11): 1093-1099 (2004). (Article)

Tan, N.S., Michalik, L., Di-Poï, N., Desvergne, B. & Wahli, W. Critical roles of the nuclear receptor PPARbeta in skin wound healing. Biochemical Society Transactions 32(Pt1): 97-102 (2004). (Article)

Di-Poï, N., Michalik, L., Tan, N.S., Desvergne, B. & Wahli, W. The anti-apoptotic role of PPARbeta contributes to efficient skin wound healing. Journal of Steroid Biochemistry & Molecular Biology 85(2-5): 257-265 (2003). (Article)

Wahli, W., Tan, A., Michalik, L., Di-Poï, N., & Desvergne, B. PPARs control cell physiology and survival. Atherosclerosis Supplements 4(2): 96-96 (2003).

Di-Poï, N., Tan, N.S., Michalik, L., Wahli, W. & Desvergne, B. Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Molecular Cell 10(4): 721-733 (2002). (Article)

Di-Poï, N., Faure, J., Grizot, S., Molnar, G., Pick, E. & Dagher, M.C. Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex. Biochemistry 40(34): 10014-10022 (2001). (Article)