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• Books

· Kaila, V.R.I,, Verkhovsky, M.I., Hummer, G. & Wikström, M. (2009) Mechanism and energetics by which glutamic acid 242 prevents leaks in cytochrome c oxidase Biochim. Biophys. Acta Bioenergetics 1787, 1205-1214

· Euro, L., Belevich, G., Wikström, M. & Verkhovskaya, M. (2009) High affinity cation binding sites in Complex I from Escherichia coli // Biochim. Biophys. Acta Bioenergetics 1787, 1024-1028

· Kim, Y.C., Wikström, M. & Hummer, G. (2009) Kinetic gating of the proton pump in cytochrome c oxidase // Proc. Natl. Acad. Sci. USA 106, 13707-13712

· Rauhamäki, V., Bloch, D.A., Verkhovsky, M.I. & Wikström, M. (2009) The active site of cytochrome cbb₃ // Biol. Chem. 284, 11301-11308

· Kaila, V.R.I., Johansson, M.P., Sundholm, D., Laakkonen, L. & Wikström, M. (2009) The chemistry of the Cu_B site in cytochrome c oxidase and the importance of its unique His-Tyr bond // Biochim. Biophys. Acta Bioenergetics 1787, 221-233

· Euro, L., Belevich, G., Bloch, D.A., Verkhovsky, M.I., Wikström, M. & Verkhovskaya, M. (2009) The role of the invariant glutamate 95 in the catalytic site of Complex I from Escherichia coli // Biochim. Biophys. Acta Bioenergetics 1787, 68-73

· Siletsky, S.A., Belevich, I., Wikström, M., Soulimane, T., Verkhovsky, M.I. (2009) Time-resolved O_H to E_H transition of the aberrant ba₃ oxidase from Thermus thermophilus // Biochim. Biophys. Acta Bioenergetics 1787, 201-205

· Wikström, M. (2008) How I became a biochemist // IUBMB Life, 60, 414-417.

· Kaila V, Verkhovsky MI, Hummer G, Wikström M. (2008) Glutamic acid 242 is a valve in the proton pump of cytochrome c oxidase. // Proc. Natl. Acad. Sci. USA 105, 6255-6259.

· Euro L, Bloch DA, Wikström M, Verkhovsky MI, Verkbovskaya M. (2008) Electrostatic interactions between FeS clusters in NADH : Ubiquinone oxidoreductase (complex I) from Escherichia coli. // Biochemistry 2008 47, 3185-3193.

· Verkhovskaya, M.L., Belevich, N., Euro, L., Wikström, M. & Verkhovsky, M.I. (2008) "Real time electron transfer in Complex I". // Proc. Natl. Acad. Sci. USA 105, 3763-3767.

· Sharma, V., Wikström, M. & Laakkonen, L. (2008) "Modeling the active-site structure of the cbb3-type oxidase from Rhodobacter sphaeroides" // Biochemistry 47, 4221-4227.

· Kaila, V.R.I., Verkhovsky, M.I., Hummer, G. & Wikström, M. (2008) "Prevention of leak in the proton pump of cytochrome c oxidase" // Biochim. Biophys. Acta 1777, 890-892.

· Gorbikova EA, Belevich I, Wikström M, Verkhovsky MI. (2008) The proton donor for O-O bond scission by cytochrome c oxidase. // Proc Natl Acad Sci USA 105, 10733-10737.

· Green, R.E., Malaspinas, A.-S., Krause, J., Briggs, A., Johnson, P.L.F., Uhler, C., Meyer, M., Good, J.M., Maricic, T., Stenzel, U., Prüfer, K., Siebauer, M., Ronan, M., Egholm, M., Rudan, P., Brajkovic, D., Kucan, Z., Gusic, I., Wikström, M., Laakkonen, L., Kelso, J., Slatkin, M. & Pääbo, S. (2008) A Complete Neandertal Mitochondrial Genome Sequence Determined by High-Throughput Sequencing // Cell 134, 416-426

· Euro, L., Belevich, G., Wikström, M. & Verkhovskaya, M. Verkhovsky M.I. (2008) Conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase (Complex I) // Biochim. Biophys. Acta Bioenergetics 1777, 1166-1172

· Gorbikova, E.A., Wikström, M. & Verkhovsky, M.I. (2008) The protonation state of the cross-linked tyrosine during the catalytic cycle of cytochrome c oxidase // J. Biol. Chem. 283, 34907-34912

· Jasaitis, A, Johansson, MP, Wikstrom, M, Vos, MH, Verkhovsky, MI. Nanosecond electron tunneling between the hemes in cytochrome bo(3). // 2007. Proc. Natl. Acad. Sci. USA 104, 20811-20814.

· Siletsky, SA, Belevich, I, Jasaitis, A, Konstantinov, AA, Wikstrom, M, Soulimane, T, Verkhovsky, MI. Time-resolved single-turnover of ba(3) oxidase from Thermus thermophilus. // 2007. Biochim. Biophys. Acta 1767, 1383-1392.

· Gorbikova, EA, Belevich, NP, Wikstrom, M, Verkhovsky, MI. Time-resolved ATR-FTIR spectroscopy of the oxygen reaction in the D124N mutant of cytochrome C oxidase from Paracoccus denitrificans. // 2007. Biochemistry 46, 13141-13148.

· Wikstrom, M, Verkhovsky, MI. Mechanism and energetics of proton translocation by the respiratory heme-copper oxidases. // 2007. Biochim. Biophys. Acta 1767, 1200-1214.

· Tuukkanen, A, Kaila, VRI, Laakkonen, L, Hummer, G, Wikstrom, M. Dynamics of the glutamic acid 242 side chain in cytochrome c oxidase. // 2007. Biochim. Biophys. Acta 1767, 1102-1106.

· Gorbikova, EA, Belevich, NP, Wikstrom, M, Verkhovsky, MI. Protolytic reactions on reduction of cytochrome c oxidase studied by ATR-FTIR spectroscopy. // 2007. Biochemistry 46, 4177-4183.

· Kim, YC, Wikstrom, M, Hummer, G. Kinetic models of redox-coupled proton pumping. // 2007. Proc. Natl. Acad. Sci. USA 104, 2169-2174.

· Belevich, I, Bloch, DA, Belevich, N, Wikstrom, M, Verkhovsky, MI. Exploring the proton pump mechanism of cytochrome c oxidase in real time. // 2007. Proc. Natl. Acad. Sci. USA 104, 2685-2690.

· Belevich, G, Euro, L, Wikstrom, M, Verkhovskaya, M. Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli. // 2007. Biochemistry 46, 526-533.

· Rauhamaki, V, Baumann, M, Soliymani, R, Puustinen, A, Wikstrom, M. Identification of a histidine-tyrosine cross-link in the active site of the cbb(3)-type cytochrome c oxidase from Rhodobacter sphaeroides. // 2006. Proc. Natl. Acad. Sci. USA 103, 16135-16140.

· Wikstrom, M, Verkhovsky, MI. Towards the mechanism of proton pumping by the haem-copper oxidases. // 2006. Biochim. Biophys. Acta 1757, 1047-1051.

· Iwaki, M, Puustinen, A, Wikstrom, M, Rich, PR. Structural and chemical changes of the P-M intermediate of Paracoccus denitrificans cytochrome c oxidase revealed by IR spectroscopy with labeled tyrosines and histidine. // 2006. Biochemistry 45, 10873-10885.

· Verkhovsky, MI, Belevich, I, Bloch, DA, Wikstrom, M. Elementary steps of proton translocation in the catalytic cycle of cytochrome oxidase. // 2006. Biochim. Biophys. Acta 1757, 401-407.

· Erkkila, K, Kyttanen, S, Wikstrom, M, Taari, K, Hikim, APS, Swerdloff, RS, Dunkel, L. Regulation of human male germ cell death by modulators of ATP production. // 2006. Am. J. Physiol. Endocrin. Metabol. 290, 1145-1154.

· Sharma, V, Puustinen, A, Wikstrom, M, Laakkonen, L. Sequence analysis of the cbb(3) oxidases and an atomic model for the Rhodobacter sphaeroides enzyme. // 2006. Biochemistry 45, 5754-5765.

· Gorbikova, EA, Vuorilehto, K, Wikstrom, M, Verkhovsky, MI. Redox titration of all electron carriers of cytochrome c oxidase by Fourier transform infrared spectroscopy. // 2006. Biochemistry 45, 5641-5649.

· Belevich, I, Verkhovsky, MI, Wikstrom, M. Proton-coupled electron transfer drives the proton pump of cytochrome c oxidase. // 2006. Nature 440, 829-832.

· Belevich, I, Tuukkanen, A, Wikstrom, M, Verkhovsky, MI. Proton-coupled electron equilibrium in soluble and membrane-bound cytochrome c oxidase from Paracoccus denitrificans. // 2006. Biochemistry 45, 4000-4006.

· Ribacka, C, Verkhovsky, MI, Belevich, I, Bloch, DA, Puustinen, A, Wikstrom, M. An elementary reaction step of the proton pump is revealed by mutation of tryptophan-164 to phenylalanine in cytochrome c oxidase from Paracoccus denitrificans. // 2005. Biochemistry 44, 16502-16512.

· Wikstrom, M, Ribacka, C, Molin, M, Laakkonen, L, Verkhovsky, M, Puustinen, A. Gating of proton and water transfer in the respiratory enzyme cytochrome c oxidase. // 2005. Proc. Natl. Acad. Sci. USA 102, 10478-10481.

· Sinegina, L, Wikstrom, M, Verkhovsky, MI, Verkhovskaya, ML. Activation of isolated NADH : ubiquinone reductase I (complex I) from Escherichia coli by detergent and phospholipids. Recovery of ubiquinone reductase activity and changes in EPR signals of iron-sulfur clusters. // 2005. Biochemistry 44, 8500-8506.

· Brudvig, GW, Wikstrom, M. Mechanistic comparisons between Photosystem II and Cytochrome Oxidase. // 2005 in (T. Wydrzynski and K. Satoh, eds.) Photosystem II: The Light-Driven Water:Plastoquinone Oxidoreductase, Chapter 31, Springer Verlag pp. 697-713.

· Wikstrom, M Cytochrome Oxidase // 2005 in Encyclopedia of Inorganic Chemistry, John Wiley & Sons, ISBN 0-470-86078-2.

· Biophysical and Structural Aspects of Bioenergetics (editor M.Wikstrom) RSC Publiching, 2005 ISBN 0-85404-346-2.

· Jobson, RW, Nielsen, R, Laakkonen, L, Wikstrom, M, Albert, VA. Adaptive evolution of cytochrome c oxidase: Infrastructure for a carnivorous plant radiation. // 2004. Proc. Natl. Acad. Sci. USA 101, 18064-18068.

· Iwaki, M, Puustinen, A, Wikstrom, M, Rich, PR. ATR-FTIR spectroscopy and isotope labeling of the P-M intermediate of Paracoccus denitrificans cytochrome c oxidase. // 2004. Biochemistry 43, 14370-14378.

· Wikstrom, M. Cytochrome c oxidase: 25 years of the elusive proton pump. // 2004. Biochim. Biophys. Acta 1655, 241-247.

· Bloch, D, Belevich, I, Jasaitis, A, Ribacka, C, Puustinen, A, Verkhovsky, MI, Wikstrom, M. The catalytic cycle of cytochrome c oxidase is not the sum of its two halves. // 2004. Proc. Natl. Acad. Sci. USA 101, 529-533.

· Blomberg, MRA, Siegbahn, PEM, Wikstrom, M. Metal-bridging mechanism for O-O bond cleavage in cytochrome c oxidase. // 2003. Inorg. Chem. 42, 5231-5243.

· Iwaki, M, Puustinen, A, Wikstrom, M, Rich, PR. ATR-FTIR spectroscopy of the P-M and F intermediates of bovine and Paracoccus denitrificans cytochrome c oxidase. // 2003. Biochemistry 42, 8809-8817.

· Wikstrom, M, Verkhovsky, MI, Hummer, G. Water-gated mechanism of proton translocation by cytochrome c oxidase. // 2003. Biochim. Biophys. Acta 1604, 61-65.

· Erkkila, K, Suomalainen, L, Wikstrom, M, Parvinen, M, Dunkel L. Chemical anoxia delays germ cell apoptosis in the human testis// 2003 Biol. Reprod. 69, 617-626.

· Wikstrom, M. Oxidative Phosphorylation - An Overview // 2003 in Genetics of mitochondrial diseases (Holt, I.J., ed.) Oxford University Press, Oxford, UK.

· Bogachev, AV, Bertsova, YV, Ruuge, EK, Wikstrom, M, Verkhovsky, MI. Kinetics of the spectral changes during reduction of the Na+-motive NADH : quinone oxidoreductase from Vibrio harveyi. // 2002. Biochim. Biophys. Acta 1556, 113-120.

· Johansson, MP, Sundholm, D, Gerfen, G, Wikstrom, M. The spin distribution in low-spin iron porphyrins. // 2002. J. Am. Chem. Soc. 124, 11771-11780.

· Wikstrom, M, Verkhovsky, MI. Proton translocation by cytochrome c oxidase in different phases of the catalytic cycle. // 2002. Biochim. Biophys. Acta 1555, 128-132.

· Johansson, MP, Blomberg, MRA, Sundholm, D, Wikstrom, M. Change in electron and spin density upon electron transfer to haem. // 2002. Biochim. Biophys. Acta 1553, 183-187.

· David, P, Baumann, M, Wikstrom, M, Finel, M. Interaction of purified NDH-1 from Escherichia coli with ubiquinone analogues. // 2002. Biochim. Biophys. Acta 1553, 268-278.

· Wikstrom, M. Oxidative phosphorylation - an overview. // 2002 in Genetics of mitochondrial diseases (Holt, I.J., ed.) Oxford University Press, Oxford, UK.ISBN 0-19-850865-4.pp 69-84.

· Verkhovsky, MI, Jasaitis, A, Wikstrom, M. Ultrafast haem-haem electron transfer in cytochrome c oxidase. // 2001. Biochim. Biophys. Acta 1506, 143-146.

· Verkhovsky, MI, Tuukkanen, A, Backgren, C, Puustinen, A, Wikstrom, M. Charge translocation coupled to electron injection into oxidized cytochrome c oxidase from Paracoccus denitrificans. // 2001. Biochemistry 40, 7077-7083.

· Morgan, JE, Verkhovsky, MI, Palmer, G, Wikstrom, M. Role of the P-R intermediate in the reaction of cytochrome c oxidase with O-2. // 2001. Biochemistry 40, 6882-6892.

· Gomes, CM, Backgren, C, Teixeira, M, Puustinen, A, Verkhovskaya, ML, Wikstrom, M, Verkhovsky, MI. Heme-copper oxidases with modified D- and K-pathways are yet efficient proton pumps. // 2001. FEBS Lett. 497, 159-164.

· Jasaitis, A, Backgren, C, Morgan, JE, Puustinen, A, Verkhovsky, MI, Wikstrom, M. Electron and proton transfer in the arginine-54-methionine mutant of cytochrome c oxidase from Paracoccus denitrificans. // 2001. Biochemistry 40, 5269-5274.

· Verkhovskaya ML, Barquera B, Wikstrom, M. Deletion of one of two Escherichia coli genes encoding putative Na+/ H+ exchangers (ycgO) perturbs cytoplasmic alkaline cation balance at low osmolarity. // 2001 Microbiology 147,3005-3013.

· Blomberg, MRA, Siegbahn, PEM, Babcock, GT, Wikstrom, M. Modeling cytochrome oxidase: A quantum chemical study of the O-O bond cleavage mechanism. // 2000. J. Am. Chem. Soc. 122, 12848-12858.

· Abramson, J, Riistama, S, Larsson, G, Jasaitis, A, Svensson-Ek, M, Laakkonen, L, Puustinen, A, Iwata, S, Wikstrom, M. The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site. // 2000. Nat. Struct. Biol. 7, 910-917.

· Blomberg, MRA, Siegbahn, PEM, Babcock, GT, Wikstrom, M. O-O bond splitting mechanism in cytochrome oxidase. // 2000. J. Inorg. Biochem. 80, 261-269.

· Wikstrom, M, Jasaitis, A, Backgren, C, Puustinen, A, Verkhovsky, MI. The role of the D- and K-pathways of proton transfer in the function of the haem-copper oxidases. // 2000. Biochim. Biophys. Acta 1459, 514-520.

· Backgren, C, Hummer, G, Wikstrom, M, Puustinen, A. Proton translocation by cytochrome c oxidase can take place without the conserved glutamic acid in subunit I. // 2000. Biochemistry 39, 7863-7867.

· Wikstrom, M. Mechanism of proton translocation by cytochrome c oxidase: a new four-stroke histidine cycle. // 2000. Biochim. Biophys. Acta 1458, 188-198.

· Riistama, S, Puustinen, A, Verkhovsky, MI, Morgan, JE, Wikstrom, M. Binding of O-2 and its reduction are both retarded by replacement of valine 279 by isoleucine in cytochrome c oxidase from Paracoccus denitrificans. // 2000. Biochemistry 39, 6365-6372.

· Wikstrom, M. Proton translocation by cytochrome c oxidase: A rejoinder to recent criticism. // 2000. Biochemistry 39, 3515-3519.

· Riistama, S, Verkhovsky, MI, Laakkonen, L, Wikstrom, M, Puustinen, A. Interaction between the formyl group of heme a and arginine 54 in cytochrome aa(3) from Paracoccus denitrificans. // 2000. Biochim. Biophys. Acta 1456, 1-4.