[photo of Mårten Wikström]

Mårten Wikström Publications



 

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Wikström, M. and Saris, N.-E. (1967) "The Effects of Hydroxylamine on Mitochondrial Respiration and Energy Transfer Reactions", Suomen Kemistilehti A40, 20.
Wikström, M.K.F. and Saris, N.-E.L. (1969) "Effect of Hydroxylamine on Respiration and Oxidative Phosphorylation", Eur. J. Biochem. 9, 160-166.
Wikström, M.K.F. (1971) "Mitochondrial Energy Transduction and Oxidative Phosphorylation; Conservation and Transfer of Energy Coupled to Oxidoreduction in the Terminal Region of the Respiratory Chain", Soc. Sci. Fenn. Comment. Biol. Vol. 43, pp. 1-42 (Dr. Med. Sci. thesis, University of Helsinki)
Wikström, M.K.F. (1971) "Inhibition of Oxidative Phosphorylation by Hydroxylamine in Sonicated Particles from Beef-Heart Mitochondria", Biochim. Biophys. Acta  234, 16-27.
Wikström, M.K.F. (1971) "Properties of Three Cytochrome b-Like Species in Mitochondria and Sub-Mitochondrial  Parti-cles", Biochim. Biophys. Acta 253, 332-345.
Wikström, M.K.F. (1971) "Effect of 2H2O on Energy-Dependent Oxidoreduction of Cytochrome b", Biochim. Biophys. Acta 245, 512-516.
Wikström, M.K.F. and Berden, J.A. (1972) "Oxidoreduction of Cytochrome b in the Presence of Antimycin", Biochim. Biophys. Acta 283, 403-420.
Wikström, M.K.F. (1972) "Energy-Linked Change in the Redox State and Absorption Spectrum of Cytochrome a in situ", Biochim. Biophys. Acta 283, 385-390.
Wikström, M.K.F. (1973) "The Different Cytochrome b Components in the Respiratory Chain of Animal Mitochondria and Their Role in Electron Transfer and Energy Conservation", Biochim. Biophys. Acta 301, 155-193.
Wikström, M.K.F. (1974) "The Principle of Energy Transduction in the Cytochrome Oxidase Region of the Respiratory Chain", Ann. N.Y. Acad. Sci. 227, 146-158.

Lambowitz, A.M., Bonner, W.D., Jr. and Wikström, M.K.F (1974) "On the Lack of ATP-induced Midpoint Potential Shift for Cytochrome b-566 in Plant Mitochondria", Proc. Natl. Acad. Sci. U.S.A. 71, 1183-1187.
Wikström, M.K.F. and Lambowitz, A.M. (1974) "The Interaction of Redox Mediators with the 'Second Phosphorylation Site'; Significance for the Cytochrome bT  Hypothesis", FEBS Lett. 40, 149-153.
Wikström, M.K.F., Ahonen, P. and Luukkainen, T. (1975) "The Role of Mitochondria in Uterine Contractions", FEBS Lett. 56, 120-123.
Wikström, M.K.F. and Saari, H.T. (1975) "A Spectral Shift in Cytochrome a produced by Ca2+ ions", Biochim. Biophys. Acta 408, 170-179.
Wikström, M.K.F. and Saari, H.T. (1976) "Conformational Changes in Cytochrome aa3 and ATP Synthetase of the Mi-tochondrial Membrane and their Role in Mitochondrial Energy Transduction", Mol. Cell. Biochem. 11, 17-34.
Wikström, M.K.F., Harmon, H.J., Ingledew, W.J. and Chance, B. (1976) "Re-evaluation of the Spectral, Redox and  Energy-Linked Properties of Cytochrome c Oxidase in  Mitochondria", FEBS Lett. 65, 259-277.
Åkerman, K.E.O. and Wikström, M.K.F. (1976) "Safranine as a Probe of the Mitochondrial Membrane Potential", FEBS Lett. 68, 191-197.
Åkerman, K.E.O., Wikström, M.K.F. and Saris, N.-E.L. (1977) "Effect of Inhibitors of the Sigmoidicity of the Ca Kinetics in Rat Liver Mitochondria", Biochim. Biophys. Acta 464, 287-294.
Wikström, M.K.F. (1977) "Proton Pump Coupled to Cytochrome c Oxidase in Mitochondria", Nature 266, 271-273.
Wikström, M.K.F. and Saari, H.T. (1977) "The Mechanism of Energy Transduction by Mitochondrial Cytochrome c Oxidase", Biochim. Biophys. Acta 462, 347-361.

Krab, K and Wikström, M. (1978) "Proton-Translocating Cytochrome c Oxidase in Phospholipid Vesicles", Biochim. Biophys. Acta 504, 200-214.
Wikström, M. and Krab, K. (1978) "Cytochrome c Oxidase is a Proton Pump - A rejoinder to recent criticism", FEBS Lett. 91, 8-14.
Harmon, H.J and Wikström, M.K.F. (1978) "The Effect of Mitochondrial Energization on Cytochrome c Oxidase Kinetics as Measured at Low Temperatures", Biochim. Biophys. Acta 503, 67-77.
Åkerman, K.E.O. and Wikström, M.K.F. (1979) "(Ca2+ + Mg2+ ) - Stimulated ATPase Activity of Rabbit Myometrium Plasma Membrane is Blocked by Oxytocin", FEBS Lett. 97, 283-285.
Penttilä, T., Saraste, M. and Wikström, M. (1979) "The Number of Subunits in Bovine Cytochrome c Oxidase", FEBS Lett. 101, 295-300.
Wikström, M. and Krab, K. (1979) "Proton-pumping Cytochrome c Oxidase" Biochim. Biophys. Acta 549, 177-222.
Wikström, M. and Krab, K. (1979) "Mechanism and Stoichiometry of Redox-linked Proton Translocation in Mitochondria", Trans. Biochem. Soc. 7, 880-887.
Krab, K. and Wikström, M. (1979) "On the Stoichiometry and Thermodynamics of Proton-pumping Cytochrome c Oxidase in Mitochondria", Biochim. Biophys. Acta 548, 1-15.
Krab, K. and Wikström, M. (1980) "Effect of 2-n-Heptyl-4-hydroxy-quinoline N-Oxide on Proton Permeability of the Mitochondrial Membrane", Biochem. J. 186, 637-639.
Saraste, M., Penttilä, T., Coggins, J.R. and Wikström, M. (1980) "Structure of Bovine Cytochrome Oxidase", FEBS Lett. 114, 35-38.

Saari, H., Penttilä, T. and Wikström, M. (1980) "Interaction of Ca2+ and H+ with Haem A in Cytochrome Oxidase", J. Bioenerg. Biomembr.  12, 325-338.
Wikström, M. (1981) "Energy-Dependent Reversal of the Cytochrome Oxidase Reaction", Proc. Natl. Acad. Sci. U.S.A. 78, 4051-4054.
Saraste, M., Penttilä, T. and Wikström, M. (1981)  "Quaternary Structure of Bovine Cytochrome Oxidase", Eur. J. Biochem.  115, 261-268.
Wikström, M. (1981) "The Question of Localised or Delocalised Proton Circuits", Trends Biochem. Sci.  6, 166-170.
Wikström, M. and Penttilä, T. (1982) "Critical Evaluation of the Proton-Translocating Property of Cytochrome Oxidase in Rat Liver Mitochondria", FEBS Lett. 144, 183-189.
Westerhoff, H.V., Helgerson, S.L., Theng, S.M., van Kooten, O., Wikström, M., Skulachev, V.P. and Dancshazy, Zs. (1983) "The Present State of the Chemiosmotic Coupling Theory" Acta Biochim. Biophys. Acad. Sci. Hung.  18, 125-149.
Semin, B.K., Saraste, M. and Wikström, M. (1984) "Calorimetric Studies of Cytochrome Oxidase-Phospholipid  Interac-tions", Biochim. Biophys. Acta  769, 15-22.
Wikström, M. (1984) "Pumping of Protons from the Mitochondrial Matrix by Cytochrome Oxidase", Nature  308,  558-560.
Wikström, M. (1984) "Two Protons are Pumped from the Mitochondrial Matrix per Electron Transferred between NADH and Ubiquinone", FEBS Lett. 169, 300-304.
Krab, K., Soos, J. and Wikström, M. (1984) "The H+/O Ratio of Proton Translocation Linked to the Oxidation of Succinate by Mitochondria", FEBS Lett.  178, 187-192.

Hemilä, H., Roberts, P. and Wikström, M. (1984) "Activated Polymorphonuclear Leucocytes Consume Vitamin C", FEBS Lett., 178, 25-30.
Hemilä, H. and Wikström, M. (1985) "Retinoids Activate Super-Oxide Production by Polymorphonuclear Leucocytes", Scand. J. Immunol. 21, 227-234.
Wikström, M. and Casey, R.P. (1985) "What is the Essential Proton-Translocating Molecular Machinery in Cytochrome Oxidase?", J. Inorg. Biochem. 23, 327-334.
Wikström, M. and Casey, R. (1985) "The Oxidation of  Exogenous Cytochrome c by Mitochondria; Resolution of a  Long-Standing Controversy", FEBS Lett. 183, 293-298.
Rich, P.R. and Wikström, M. (1986) "Evidence for a Mobile Semi-Quinone in the Redox Cycle of the Mammalian Cytochrome bc1 complex", FEBS Lett. 194, 176-182.
Wikström, M. and Krab, K. (1986) "The Semiquinone Cycle; A Hypothesis of Electron Transfer and Proton Translocation in Cytochrome bc-Type Complexes", J. Bioenerg. Biomembr. 18, 181-193.
Krab, K. and Wikström, M. (1986) "Determination of the Stoichiometry of Redox-Linked Proton Translocation from the Kinetics of Pulse Experiments. A Simulation Study", FEBS Lett.  201, 198-204.
Finel, M. and Wikström, M. (1986) "Studies on the Role of the Oligometric State and Subunit III of Cytochrome Oxidase in Proton Translocation", Biochim. Biophys. Acta 851, 99-108.
Wikström, M. (1987) "Insight into the Mechanism of Cellular Respiration from its Partial Reversal in Mitochondria", Chemica Scripta 27B, 53-58.
Holm, L., Saraste, M., and Wikström, M. (1987) "Structural models of the redox centres in cytochrome oxidase", EMBO J. 6, 2819-2823.

Krab, K. and Wikström, M. (1987) "Principles of linkage between electron transfer and  proton translocation with special reference to proton translocation mechanisms in cytochrome oxidase", Biochim. Biophys. Acta 895, 25-39.
Wikström, M. (1988) "Mechanism of Cell Respiration. Properties of individual reaction steps in the catalysis of dioxygen reduction by cytochrome oxidase", Chemica Scripta 28A, 71-74.
Wikström, M. (1988) "Protonic sidedness of the binuclear iron-copper centre in cytochrome oxidase" FEBS Lett. 231, 247-252.
Wikström, M. (1988) "How does cytochrome oxidase pump protons? A 'cooperative proton pump' model", Ann. N.Y. Acad. Sci. 550, 199-206.
Finel, M. and Wikström, M. (1988) "Monomerization of cytochrome oxidase may be essential for the removal of  subunit III", Eur. J. Biochem. 176, 125-129.
Majander, A. and Wikström, M. (1989) "The plasma membrane potential of human neutrophils. Role of ion channels and the sodium/potassium pump", Biochim. Biophys. Acta 980, 139-145.
Wikström, M. (1989) "Identification of the electron  transfers in cytochrome oxidase that are coupled to  proton-pumping" Nature 338, 776-778. 
Puustinen, A., Finel, M., Virkki, M. and Wikström, M. (1989) "Cytochrome o (bo) is a proton pump in Paracoccus  denitrificans and Escherichia coli", FEBS Lett. 249, 163-167.
Haltia, T., Finel, M., Harms, N., Nakari, T., Raitio, M., Wikström, M. and Saraste, M. (1989) "Deletion of the gene for subunit III leads to defective assembly of bacterial cytochrome oxidase", EMBO J. 8, 3571-3579.
Aaku, E., Sorsa, T. and Wikström, M. (1990) "Human immunoglobulin G potentiates superoxide production induced by chemotactic peptides and causes degranulation in isolated human neutrophils", Biochim. Biophys. Acta  1052, 243-247.

Wikström, M. and Babcock, G. T. (1990) "Cell Respiration; Catalytic Intermediates", Nature 348, 16-17 ("News and Views").
Morgan, J.E. and Wikström, M. (1991) "Steady state redox behaviour of cytochrome c, cytochrome a, and CuA of cytochro-me c oxidase in intact rat liver mitochondria", Biochemistry 30, 948-958.
Puustinen, A., Finel, M., Haltia, T., Gennis, R. B. and Wikström, M. (1991) "Properties of the two terminal oxidases of E. coli",  Biochemistry 30, 3936-3942.
Lauraeus, M., Haltia, T., Saraste, M. and Wikström, M. (199-1) "Bacillus subtilis expresses two kinds of haem A-containing terminal oxidases", Eur. J. Biochem. 197, 699-705.
Haltia, T., Saraste, M. and Wikström, M. (1991) "Subunit III of cytochrome c oxidase is not involved in proton translocation: a site-directed mutagenesis study". EMBO J. 10,  2015-2021.
Puustinen, A. and Wikström, M. (1991) "The haem groups of cytochrome o from E. coli", Proc. Natl. Acad. Sci. USA  88, 6122-6126.
Majander, A., Huoponen, K., Savontaus, M.-L., Nikoskelainen, E. and Wikström, M. (1991) "Electron transfer properties of NADH: ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON)", FEBS Lett. 292, 289-292.
Wu, W., Chang, C.K., Varotsis, C., Babcock, G.T., Puustinen, A. and Wikström, M. (1992) "Structure of the Heme o Prosthetic Group from the Terminal Quinol Oxidase of E. coli", J. Am.Chem.Soc. 114, 1182-1187.
Babcock, G.T. and Wikström, M. (1992) "O2 activation and the conservation of energy in cell respiration", Nature  356, 301-309.
Wikström, M. and Morgan, J.E. (1992) "The dioxygen cycle: spectral, kinetic and thermodynamic characteristics of ferryl and peroxy intermediates observed by reversal of the cytochrome oxidase reaction", J. Biol. Chem  267, 10266-10273.

Verkhovskaya, M., Verkhovsky, M. and Wikström, M. (1992) "pH-dependence of proton translocation by Escherichia coli",  J. Biol. Chem. 267, 14559-14562.
Puustinen, A., Morgan, J.E., Verkhovsky, M., Thomas, J.W., Gennis, R. and Wikström, M. (1992) "The low spin heme site of cytoch-rome o from E. coli is promiscuous with respect to heme type", Biochemistry 31, 10363-10369.
Lauraeus, M., Wikström, M., Varotsis, C., Tecklenburg,     M.M.J., and Babcock, G.T. (1992) "Optical and Resonance     Raman Spectroscopy of the Heme Groups of the Quinol-Oxidizing Cytochrome aa3 of Bacillus subtilis", Biochemistry 31, 10054-10060.
Verkhovsky, M., Morgan J.E. and Wikström, M. (1992) "Intramolecular electron transfer in cytochorome c oxidase; a cascade of equilibria", Biochemistry 31, 11860-11863.
Lauraeus, M.I., Morgan, J.E. and Wikström, M. (1993) "Peroxy and Ferryl Intermediates of the Quinol-Oxidizing Cytochrome aa3 from Bacillus subtilis", Biochemistry 32, 2664-2670.
Thomas, J. W., Puustinen, A., Alben, J. O., Gennis, R. B. and Wikström, M. (1993) "Substitution of Asparagine for Aspartate 135 in Subunit I of the Cytochrome bo Ubiquinol Oxidase of Escherichia coli Eliminates Proton Pumping Activity", Biochemistry 32, 10923-10928.
Morgan, J. E., Verkhovsky, M., I., Puustinen, A. and Wikström, M. (1993) "Intramolecular electron transfer in cytochrome o of Escherichia coli: events following the photolysis of fully and partially reduced CO-bound forms of the bo3 and oo3 enzymes", Biochemistry 32, 11413-11418.
Lauraeus M. and Wikström, M. (1993) "The terminal quinol oxidases of Bacillus subtilis have different energy conservation properties", J. Biol. Chem. 268, 11470-11473.
Powers, L., Lauraeus, M., Reddy, K., S., Chance, B. and Wikström, M. (1994) "Structure of the binuclear heme iron-copper site in the quinol-oxidizing cytochrome aa3 from Bacillus subtilis", Biochim. Biophys. Acta 1183, 504-512.
Verkhovsky, M. I., Morgan, J. E. and Wikström, M. (1994) "Oxygen binding and activation: early steps in the reaction of oxygen with cytochrome c oxidase", Biochemistry 33, 3079-3086.

Raitio, M. and Wikström, M. (1994) "An alternative cytochrome oxidase of Paracoccus denitrificans functions as a proton pump", Biochim. Biophys. Acta 1186, 100-106.
Wikström, M., Bogachev, A., Finel, M., Morgan, J. E., Puustinen, A., Raitio, M., Verkhovskaya, M. and Verkhovsky, M. (1994) "Mechanism of proton translocation by the respiratory oxidases: The Histidine Cycle", Biochim. Biophys. Acta 1187, 106-111.
Majander, A., Finel, M. and Wikström, M. (1994) "Diphenyleneiodonium (DPI) inhibits reduction of the iron-sulfur clusters in the mitochondrial NADH:ubiquinone oxidoreductase (Complex I)", J. Biol. Chem. 269, 21037-21042.
Thomas, J.W., Calhoun, M.W., Lemieux, L.J., Puustinen, A., Wikström, M., Alben, J.O. and Gennis, R.B. (1994) "Site-directed mutagenesis of residues within helix VI in subunit I of the cytochrome bo3 ubiquinol oxidase from Eschericia coli suggests that tyrosine-288 may be a CuB ligand", Biochemistry 33, 13013-13021.
Morgan, J.E., Verkhovsky, M.I. and Wikström, M. (1994) "The Histidine Cycle: A New Model for Proton Translocation in the Respiratory Heme-Copper Oxidases", J. Bioenerg. Biomembr. 26, 599-608.
Finel, M., Majander, A.S., Tyynelä, J., deJong, A.M.Ph., Albracht, S.P.J., and Wikström, M. (1994) "Isolation and characterisation of subcomplexes of the mitochondrial NADH:ubiquinone oxidoreductase (Complex I)", Eur. J. Biochem. 226, 237-242.
Varotsis, C., Babcock, G.T., Lauraeus, M. and Wikström, M. (1995) "Raman detection of a peroxy intermediate in the hydroquinone-oxidizing cytochrome aa3 of Bacillus subtilis", Biochim. Biophys. Acta  1231, 111-116.
Garcia-Horsman, J.A., Puustinen, A., Gennis, R.B. and Wikström, M. (1995) "Proton transfer in cytochrome bo3 ubiquinol oxidase of Eschericia coli. Second site mutations in subunit I that restore proton pumping in the mutant Asp135->Asn", Biochemistry 34, 4428-4433.
Lamminen, T., Majander, A., Juvonen, V., Wikström, M., Aula, P, Nikoskelainen, E. and Savontaus, M.-L. (1995) "A Mitochondrial Mutation at NT 9101 in the ATP Synthase 6 Gene Associated with Deficient Oxidative Phosphorylation in a Family with Leber Hereditary Optic Neuroretinopathy", Am. J. Human Gen. 56, 1238-1240.
Verkhovsky, M.I., Morgan, J.E. and Wikström, M. (1995) "Control of Electron Delivery to the Oxygen Reduction Site of Cytochrome c Oxidase: A Role for Protons", Biochemistry 34, 7483-7491.

Verkhovskaya, M.L., Verkhovsky, M.I. and Wikström, M. (1995) "A novel antiporter activity catalyzing sodium and potassium transport from right-side-out vesicles of E. coli", FEBS Lett. 363, 46-48.   
Fann, Y.C., Ahmed, I., Blackburn, N.J., Boswell, J.S., Verkhovskaya, M.L., Hoffman, B.M. and Wikström, M. (1995) "Structure of CuB in the binuclear heme-copper center of the cytochrome aa3-type quinol oxidase from Bacillus subtilis. An ENDOR and EXAFS study", Biochemistry 34, 10245-10255.
Morgan, J.E., Verkhovsky, M.I., Puustinen, A., and Wikström, M. (1995) "Identification of a 'peroxy' intermediate in cytochrome bo3 of Escherichia coli", Biochemistry 34, 15633-15637.
Zickermann, V., Verkhovsky, M., Morgan, J., Wikström, M., Anemüller, S., Bill, E., Steffens, G.C.M., and Ludwig, B. (1995) "Perturbation of the CuA site in cytochrome c oxidase of Paracoccus denitrificans by replacement of Met227 with isoleucine", Eur. J. Biochem. 234, 686-693.
Puustinen, A., Verkhovsky, M.I., Morgan, J.E., Belevich, N.P. and Wikström, M. (1996) "Reaction of the E. coli  quinol oxidase cytochrome bo3 with dioxygen: the role of a bound ubiquinone molecule", Proc. Natl. Acad. Sci. USA 93, 1545-1548.
Fox, S., Nanthakumar, A., Wikström, M., Karlin, K.D. and Blackburn, N.J. (1996) "XAS structural comparisons of reversibly interconvertible oxo- and hydroxo-bridged heme-copper oxidase model compounds", J. Am. Chem. Soc. 118, 24-34.
Verkhovsky, M.I., Morgan, J.E., Puustinen, A., and Wikström, M. (1996) "Kinetic trapping of O2 in cell respiration", Nature 380, 268-270.
Verkhovskaya, M.L., Verkhovsky, M.I. and Wikström, M. (1996) "K+-dependent Na+ transport driven by respiration in E. coli cells and membrane vesicles", Biochim. Biophys. Acta 1273, 207-216.
Riistama, S., Puustinen, A., Garcia-Horsman, A., Iwata, S., Michel, H. and Wikström, M. (1996) "Channeling of dioxygen into the respiratory enzyme", Biochim. Biophys. Acta 1275, 1-4.
Majander, A., Savontaus, M.-L., Nikoskelainen, E. and Wikström, M. (1996) "Catalytic activity of complex I in cell lines that possess replacement mutations in the ND genes in Leber's hereditary optic neuropathy", Eur.J. Biochem. 239, 201-207.

Verkhovskaya, M.L., Verkhovsky, M.I, and Wikström, M. (1996) "The respiration-driven active sodium transport system in E. coli does not function with lithium", FEBS Lett. 388, 217-218.
Verkhovsky, M.I., Morgan, J.E. and Wikström, M. (1996) "Redox transitions between oxygen intermediates in cytochrome c oxidase", Proc. Natl. Acad. Sci. USA 93, 12235-12239.
Verkhovsky, M.I., Morgan, J.E., Puustinen, A. and Wikström, M. (1996) "The 'ferrous-oxy' intermediate in the reaction of dioxygen with fully reduced cytochromes aa3 and bo3", Biochemistry 35, 16241-16246.
Morgan, J.E., Verkhovsky, M.I. and Wikström, M. (1996) "Observation and assignment of peroxy and ferryl intermediates in the reduction of dioxygen to water by cytochrome c oxidase", Biochemistry 35, 12235-12240.
Verkhovsky, M.I., Morgan, J.E., Verkhovskaya, M.L. and Wikström, M. (1997) "Translocation of electrical charge during a single turnover of cytochrome c oxidase", Biochim. Biophys. Acta 1318, 6-10.
Wikström, M., Morgan, J.E. and Verkhovsky, M.I. (1997) "Proton and electrical charge translocation by cytochrome c oxidase", Biochim. Biophys. Acta 1318, 299-306.
Majander, A., Lamminen, T., Juvonen, V., Aula, P., Nikoskelainen, E., Savontaus, M.-L. and Wikström, M. (1997) “Mutations in subunit 6 of the F1Fo-ATP synthase cause two entirely different diseases”, FEBS Lett. 412, 351-354.
Puustinen, A., Bailey, J.A., Dyer, R.B., Mecklenburg, S.L., Wikström, M. and Woodruff, W.H. (1997) “Fourier transform infrared evidence for connectivity between CuB and glutamic acid 286 in cytochrome bo3 from E. coli”, Biochemistry 36, 13195-13200.
Verkhovskaya, M.L., Garcìa-Horsman, A., Puustinen, A., Rigaud, J.-L., Morgan, J.E., Verkhovsky, M.I. and Wikström, M. (1997) “Glutamic acid 286 in subunit I of cytochrome bo3 is involved in proton translocation”, Proc. Natl. Acad. Sci. USA 94, 10128-10131.
Riistama, S., Hummer, G., Puustinen, A., Dyer R.B., Woodruff, W. H., and Wikström,  M. (1997) “Bound water in the proton translocation mechanism of the haem-copper oxidases”, FEBS Lett. 414, 275-280.

Wikström, M., Morgan, J.E. and Verkhovsky, M.I. (1998) “On the mechanism of proton translocation by respiratory enzyme”, J. Bioenerg. Biomembr. 30, 139-145.
Pomès, R., Hummer, G. and Wikström, M. (1998) “Structure and dynamics of a proton shuttle in cytochrome c oxidase”, Biochim. Biophys. Acta 1365, 255-260.
Wikström, M. (1998) “Proton translocation by the respiratory haem-copper oxidases”, Biochim. Biophys. Acta 1365,  185-192.
Wikström, M. (1998) “Proton translocation by bacteriorhodopsin and heme-copper oxidases”, Curr. Opin. Struct. Biol. 8, 480-488.
Toledo-Cuevas, M., Barquera, B., Gennis, R.B., Wikström, M. and García-Horsman, J.A. (1998) “The cbb3-type cytochrome c oxidase from Rhodobacter sphaeroides, a proton-pumping heme-copper oxidase”, Biochim. Biophys. Acta  1365, 421-434.
Zickermann, V., Barquera, B., Wikström, M. and Finel, M. (1998) “Analysis of the pathogenic human mitochondrial mutation ND1/3460, and mutations of strictly conserved residues in its vicinity, using the bacterium Paracoccus denitrificans”, Biochemistry 37, 11792-11796.
Verkhovskaya, M.L., Barquera, B., Verkhovsky, M.I. and Wikström, M. (1998) “The Na+ and K+ transport deficiency of an E. coli mutant lacking the NhaA and NhaB proteins is apparent and caused by impaired osmoregulation”, FEBS Lett. 439, 271-274.
Ma, J., Puustinen, A., Wikström, M. and Gennis, R.B. (1998) “Tryptophan-136 in subunit II of cytochrome bo3 from Escherichia coli may participate in the binding of ubiquinol”, Biochemistry 37, 11806-11811.
Puustinen, A. and Wikström, M. (1999) “Proton exit from the heme-copper oxidase of Escherichia coli”, Proc. Natl. Acad. Sci. USA. 96, 35-37.
Jasaitis, A., Verkhovskaya, M., Morgan, J. E., Verkhovsky, M. and Wikström, M. (1999) "Assignment and Charge Translocation Stoichiometries of the Major Electrogenic Phases in the Reaction of Cytochrome c Oxidase with Dioxygen", Biochemistry 38, 2697-2706.

Ralle, M., Verkhovskaya, M. L., Morgan, J. E., Verkhovsky, M. I., Wikström, M. and Blackburn, N. J. (1999) "Coordination of CuB in Reduced and CO-liganded States of Cytochrome bo3 from Escherichia coli; Is Chloride Ion a Cofactor?", Biochemistry 38, 7185-7194.
Verkhovsky, M.I., Belevich, N., Morgan, J.E. and Wikström, M. (1999) "Proton Linkage of Cytochrome a Oxidoreduction in Carbon Monoxide-Treated Cytochrome c Oxidase", Biochim. Biophys. Acta 1412, 184-189.
Verkhovsky, M.I., Jasaitis, A., Verkhovskaya, M.L., Morgan, J.E. and Wikström, M. (1999) "Proton translocation by cytochrome c oxidase", Nature 400, 480-483.
Riistama, S., Laakkonen, L., Wikström, M., Verkhovsky, M.I. and Puustinen, A. (1999) "The calcium binding site in cytochrome aa3 from Paracoccus denitrificans", Biochemistry 38, 10670-10677.
Erkkilä, K., Pentikäinen, V., Wikström, M., Parvinen, M. and Dunkel, L. (1999) "Partial oxygen pressure and mitochondrial permeability transition affect germ cell apoptosis in the human testis" J. Clin. Endocrin. Metab. 84, 4253-4259.
Ma, J., Tsatsos, P.H., Zaslavsky, D., Barquera, B., Thomas, J.W., Katsonouri, A., Puustinen, A. Wikström, M., Brzezinski, P., Alben, J.O. and Gennis, R.B. (1999) "Glutamate-89 in subunit II of cytochrome bo3 from Escherichia coli is required for the function of the heme-copper oxidase", Biochemistry 38, 15150-15156.
Verkhovsky, M.I., Jasaitis, A., Verkhovskaya, M.L., Morgan, J.E. and Wikström, M. (1999) "Proton pumping by cytochrome c oxidase", Nature 402, 603 (Brief Communication).
Riistama, S., Verkhovsky, M.I., Laakkonen, L., Wikström, M. and Puustinen, A. (2000) "Interaction between the formyl group of heme a and arginine 54 in cytochrome aa3 from Paracoccus denitrificans", Biochim. Biophys. Acta 1456, 1-4.
Wikström, M. (2000) "Mechanism of proton translocation by cytochrome c oxidase: A new four-stroke histidine cycle", Biochim. Biophys. Acta 1458, 188-198.
Wikström, M. (2000) "Proton translocation by cytochrome c oxidase: a rejoinder to recent criticism", Biochemistry 39, 3515-3519.

Blomberg, M.R.A., Siegbahn, P.E.M., Babcock, G.T. and Wikström, M. (2000) "O-O splitting mechanism in cytochrome c oxidase", J. Inorg. Biochem., 80, 261-269.
Riistama, S., Puustinen, A., Verkhovsky, M.I., Morgan, J.E. and Wikström, M. (2000) "Binding of O2 and its reduction are both retarded by replacement of  valine 279 by isoleucine in cytochrome c oxidase from Paracoccus denitrificans", Biochemistry 39, 6365-6372.
Backgren, C., Hummer, G., Wikström, M. and Puustinen, A. (2000) "Proton translocation by cytochrome c oxidase can take place without the conserved glutamic acid in subunit I", Biochemistry 39, 7863-7867.
Wikström, M., Jasaitis, A., Backgren, C., Puustinen, A. and Verkhovsky, M.I. (2000) "The Role of the D- and K-pathways of Proton Transfer in the Function of the Haem-Copper Oxidases", Biochim. Biophys. Acta 1459, 514-520.
Abramson, J., Riistama, S., Larsson, G., Jasaitis, A., Svensson-Ek, M., Laakkonen, L., Puustinen, A., Iwata, S. and Wikström, M. (2000) "The structure of the heme-copper oxidase from Escherichia coli and its binding site for ubiquinone", Nature Struct. Biol. 7, 910-917.
Blomberg, M.R.A., Siegbahn, P.E.M., Babcock, G.T. and Wikström, M. (2000) "Modeling cytochrome c oxidase – a quantum chemical study of the O-O bond cleavage mechanism", J. Am. Chem. Soc. 122, 12848-12858.
Jasaitis, A., Backgren, C., Morgan, J.E., Puustinen, A., Verkhovsky, M.I. and Wikström, M. (2001) "Electron and proton transfer in the arginine-54-methionine mutant of cytochrome c oxidase from Paracoccus denitrificans", Biochemistry, 40, 5269-5282.
Verkhovskaya, M.L., Barquera, B. and Wikström, M. (2001) "Deletion of one of two Escherichia coli genes encoding putative Na+/H+ exchangers (ycgO) perturbs cytoplasmic alkali cation balance at low osmolarity", Microbiology, 147, 3005-3013.
Verkhovsky, M.I., Tuukkanen, A., Backgren, C., Puustinen, A. and Wikström, M. (2001) "Charge translocation coupled to electron injection into oxidized cytochrome c oxidase from Paracoccus denitrificans", Biochemistry, 40, 7077-7083.
Gomes, C., Backgren, C., Teixeira, M., Puustinen, A., Verkhovskaya, M., Wikström, M. and Verkhovsky, M.I. (2001) ”Heme-copper oxidases with modified D- and K-pathways are yet efficient proton pumps”, FEBS Lett., 497, 159-164.

Morgan, J.E., Verkhovsky, M.I., Palmer, G. and Wikström, M. (2001) "The Role of the PR Intermediate in the Reaction of Cytochrome c Oxidase with O2", Biochemistry, 40, 6882-6892.
Verkhovsky, M.I., Jasaitis, A. and Wikström, M. (2001) “Ultrafast Haem-Haem Electron Transfer in Cytochrome c Oxidase”, Biochim. Biophys. Acta 1506, 143-146. 
Johansson, M.P., Blomberg, M.R.A., Sundholm, D. and Wikström, M. (2002) "Change in electron and spin density upon electron transfer to haem", Biochim. Biophys. Acta 1553, 183-187.
David, P., Baumann, M., Wikström, M. and Finel, M. (2002) "Interaction of purified NDH-1 from Escherichia coli with ubiquinone analogues", Biochim. Biophys. Acta 1553, 268-278.
Wikström, M. and Verkhovsky, M.I. (2002) "Proton translocation by cytochrome c oxidase in different phases of the catalytic cycle", Biochim. Biophys. Acta 1555, 128-132.
Johansson, M., Sundholm, D., Gerfen, G. and Wikström, M. (2002) "Spin Distribution in Low Spin Iron-Porphyrin Complexes", J. Am. Chem. Soc. 124, 11771-11780.
Wikström, M., Verkhovsky, M.I. and Hummer, G. (2003) "Water-gated mechanism of proton translocation by cytochrome c oxidase", Biochim. Biophys. Acta-Bioenergetics 1604, 61-65.


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Wikström, M. (1967) "Kontroll av cellproliferation och cancer". Meditrina, 2: 48. ("Control of Cell Proliferation and Cancer"; in Swedish)
Saris, N.-E.L., Wikström, M.K.F. and Seppälä, A.J. (1969) "The Effects of Oligoamines on Cation Binding in Mitochondria", in Mitochondria - Structure and Function, (L. Ernster and Z. Drahota, eds.), Academic Press, New York and London, pp. 363-368.
Wikström, M.K.F. (1970) "The Inhibition of Oxidative Phosphorylation by Hydroxylamine", in Electron Transport and Energy Conservation, (J.M. Tager, S. Papa, E. Quagliariello and E.C. Slater, eds.), Adriatica Editrice, Bari, pp. 153-170.
Wikström, M.K.F. and Saris, N.E-L. (1970) "The Reversal of Electron Transfer Across the Terminal Energy-Conservation Site", ibid, pp. 77-88.
Wikström, M.K.F. (1970) "A Comparison Between the Effects of Hydroxylamine Azide and Oligomycin on Energy-Linked Reactions in Mitochondria", ibid, pp. 215-218.
Wikström, M.K.F. (1971) Anomalous Energy-Linked  Oxidoreduction of Cytochrome b in Rat-Liver Mitochondria", in Energy Transduction in Respiration and Photosynthesis (E. Quagliarello, S. Papa and C.S. Rossi, eds.), Adriatica Editrice, Bari, pp. 693-709.
Wikström, M.K.F. (1971) "The Cytochrome b Complex and Energy Conservation: A possible Relation Between Proton Transfer and Oxidative Phosphorylation", in Biochemistry and Biophysics of Mitochondrial Membranes (G.F. Azzone, E. Carafoli, A.L. Lehninger, E. Qualiariello and N. Siliprandi, eds.), Academic Press, New York and London, pp. 147-164.
Seppälä, A.J., Wikström, M.K.F. and Saris, N.-E.L. (1973)  "Damping of Mitochondrial Volume Oscillations by Propranolol and Related Compounds", in Biological and Biochemical  Oscillators, (B. Chance, E.K. Pye, A.K. Ghosh and B. Hess, eds.) Academic Press, New York and London, pp. 115-124.
Wikström, M.K.F. and Berden, J.A. (1973) "On the Behaviour of Cytochrome b in the Energized Mitochondrial Membrane", in Mechanisms in Bioenergetics (G.F. Azzone, L. Ernster, S.Papa, E. Qualiariello and N. Siliprandi, eds.), Academic Press, New York and London, pp. 545-560.
Bonner, W.D., Jr. Lambowitz, A.M. and Wikström, M.K.F. (1974) "On the Lack of ATP-induced Midpoint Potential Shift in Cytochrome b-566 in Plant Mitochondria", Proc. Congr. on Energy-Transduction Membrane Functions (I.U.B. Symp. No. 59, Stockholm) BBA Library Vol. 13, Elsevier Publ. Co., pp. 195-200.

Wikström, M. (1973) "Mitokondrierna - teoretisk och biomedicinsk forskning". Finska Läkaresällskapets Handlingar 117: 88-98 ("The mitochondria - theoretical and biomedical research"; in Swedish).
Wikström, M.K.F., Ahonen, P. and Luukkainen, T. (1974) "A Possible Regulatory Role in Mitochondrial Calcium Uptake in Uterine Contractions", in Physiology and Genetics of  Reproduction (E. Coutinho and F. Fuchs, eds.) Plenum Publishing Corp., New York, Part B, pp. 177-188.
Chance, B., Harmon, J. and Wikström, M. (1975) "Molecular Events in Energy Coupling Reactions: The Effect of Energiza-tion upon the Formation and Interconversion of Oxygen Com-pounds of Cytochrome Oxidase" in Electron Transfer Chains and Oxidative Phosphorylation (E. Qualiariello et al., eds.), North-Holland Publ. Co., pp. 81-95.
Wikström, M.K.F. (1975) "Energy-Linked Conformational Changes in Cytochrome c Oxidase of the Mitochondrial Membrane, ibid,  pp. 97-103.
Wikström, M. (1975) "Solun Energiatuotannon Säätely", Duodecim 91: 1367-1379 ("Regulation of Cellular Energy Production"; in Finnish).
Saris, N.-E.L., Wikström, M.K.F. and Saari, H.T. (1975) in Calcium Transport in Contraction and Secretion (E. Carafoli, F. Clementi, W. Drabinowski and A. Margreth, eds.) ("Interactions Between Ca2+, Cytochrome Oxidase and the Energy State of Mitochondria), North-Holland Publ. Co., Amsterdam, pp. 95-102.
Wikström, M.K.F. (1976) "On the Role of Conformational Changes in Cytochrome c Oxidase in the Mechanism and Control of Oxidative Phosphorylation", EURATOM Symposium on "Mitochondrial Genetics, Biogenesis and Bioenergetics", De Gruyter and Co., Berlin, pp. 325-348.
Wikström, M. (1977) "Aivojen Energia-Aineenvaihdunnasta" ("On Brain Energy Metabolism"; in Finnish), Sandoz Report 8 (1) 271-273.
Wikström, M.K.F. (1978) "Cytochrome c Oxidase - The Mechanism of a Redox-Coupled Proton Pump", in (G.F. Azzone et al., eds.) Mechanisms of Calcium and Proton Pumps,  Elsevier North-Holland, Amsterdam, pp. 215-266.
Wikström, M.K.F., Saari, H.T., Penttilä, T. and Saraste, M. (1978) "Functioning of Cytochrome c Oxidase in the  Mitochondrial Membrane and in Vesicles", FEBS Symp., Vol.  45, Pergamon Press, Oxford and New York, pp. 85-94.

Wikström, M.K.F. and Krab, K. (1978) "Redox-linked Proton Pumps in Mitochondria" in (G. Schäfer and M. Klingenberg, eds.) Energy Conservation in Biological Membranes, Springer Verlag, pp. 128-139.
Wikström, M. and Krab, K. (1979) "On the Proton-pumping Function of cytochrome c Oxidase", in (Y. Mukohata and L. Packer, eds.) Cation Flux Across Biomembranes, Academic Press, pp. 321-329.
Wikström , M. and Krab, K. (1979) "Generation of Electrochemical Proton Gradient by Mitochondrial Cytochrome c Oxidase: Clarification of Some Controversial Experiments",  in (P.L. Dutton et al., eds.) Frontiers of Biological  Energetics, Academic Press, 351-358.
Wikström, M. (1978) "Vuoden 1978 Kemian Nobelin Palkinto", Kemia-Kemi 5: 659 ("The 1978 Chemistry Nobel Award"; in Finnish).
Wikström, M. (1978) "Kemian Nobelin Palkinto", Duodecim 94: 1470-1472 ("The Nobel Award in Chemistry"; in Finnish).
Wikström, M. and Sigel, E. (1979) "Proton Translocation Catalyzed by Mitochondrial Cytochrome Oxidase", in (E. Carafoli and G. Semenza, eds.) Membrane Biochemistry,  Springer-Verlag, New York, pp. 89-91.
Wikström, M. and Krab, K. (1980) "Respiration-linked H+ Translocation in Mitochondria" in (D.R. Sanadi, ed.) Current Topics in Bioenergetics, Academic Press, New York, Vol. 10, pp.51-101.
Wikström, M. (1980) "Mechanism of Proton Translocation by Mammalian Cytochrome Oxidase", Proc. 1st Eur. Bioenerg.  Conference, Urbino, Italy, 1980, pp. 253-254 (Patron  Editore, Bologna).
Wikström, M. (1982) "Proton Translocation by Cytochrome Oxidase" in (Slayman, C., ed.) Curr. Topics in Membranes and Transport, Academic Press, New York, pp. 303-321.
Wikström, M. (1982) "Properties of Cytochrome Oxidase Relevant to its Proton-Translocating Function" in (C. Ho, ed.) Electron Transport and Oxygen Utilization, Elsevier Publ. Co., New York, pp. 271-277.

 Saraste, M., Penttilä, T. and Wikström, M. (1982) "Protomer Model for Mitochondrial Cytochrome Oxidase", ibid., pp. 165-170.
Wikström, M., Krab, K. and Saraste, M. (1981) "Proton-Translocating Cytochrome Complexes", Annu. Rev. Biochem. 50, 623-655.
Wikström, M. (1981) "Cytochrome Oxidase" in (C.P. Lee, G. Schatz and G. Dallner, eds.) Mitochondria and Microsomes, Addison-Wesley, Reading, Mass. pp. 249-269.
Wikström, M., Krab, K. and Saraste, M. (1981) "Cytochrome Oxidase - A Synthesis", Academic Press, London, pp. 1-198 (monograph).
Wikström, M. (1982) "Proton Translocation by Cytochrome Oxidase" in (A.N. Martonosi, ed.) Membranes and Transport 1980, Plenum Publ. Co., New York, pp. 357-362.
Wikström, M. (1981) "Protonmotive Function of Cytochrome Oxidase" in (V.P. Skulachev and P.C. Hinkle, eds.) Chemiosmotic Proton Circuits in Biological Membranes,  Addison-Wesley, Reading, Mass. pp. 171-190.
 Wikström, M. (1981) "Mitokondrion sisäkalvo - perintö muinaisilta bakteereilta", Duodecim 18: 1546-1553 ("The inner mitochondrial membrane - an inheritance from ancient bacteria"; in Finnish).
Penttilä, T. and Wikström, M. (1981) "Mechanism of Proton/ Electron Coupling in Cytochrome Oxidase" in (F. Palmieri et al., eds.) Vectorial Reactions in Electron and Ion Transport in Mitochondria and Bacteria, Elsevier/North-Holland Biomedical Press, Amsterdam, pp. 71-80.
Åkerman, K. and Wikström, M. (1982) "Calciumjonen - en metabolisk signal i cellerna", Finska Läkaresällsk. Handl. 126: 8-16 ("The Calcium Ion - A Metabolic Signal in Cells"; in Swedish).
Wikström, M., Saraste, M. and Penttilä, T. (1985) "Relationships Between Structure and Function in Cytochrome Oxidase" in (A.N. Martonosi, ed.) The Enzymes of Biological Membranes, Vol. 4, Plenum Publ. Co., 111-148.

Saraste, M. and Wikström, M. (1983) "On the Location of Prosthetic groups in cytochrome aa3 and bc1 " in (E.  Quagliariello & F. Palmieri, eds.) Structure and Function of Membrane Proteins, Elsevier Science Publ. pp. 139-144.
Wikström, M. and Saraste, M. (1984) "The Mitochondrial Respiratory Chain" in (L. Ernster, ed.) New Comprehensive Biochemistry, Bioenergetics, Elsevier Biomedical Press, Amsterdam, pp. 49-94.
Wikström, M. (1985) "Syret - ett Biologiskt Bränsle på Gott och Ont" ("Oxygen, a Biological Fuel at a Price"; in Swedish) Finska Läkaresällsk. Handl. 129: 263-268.
Wikström, M. (1987) "Catalytic mechanism of O2 reduction by cytochrome oxidase" In: Cytochrome systems: Molecular  Biology and Bioenergetics (S. Papa et al., eds.) Plenum Press, N.Y., pp. 377-383.
Finel, M., Haltia, T., Holm, L., Jalli, T., Metso, T., Puustinen, A., Raitio, M., Saraste, M., and Wikström, M. (1987) "Universal features in cytochrome oxidase" In: Cytochrome systems: Molecular Biology and Bioenergetics (S. Papa et al., eds.)  Plenum press, New York, pp. 247-252.
Wikström, M. (1988) "The mechanism of reduction of dioxygen catalysed by cytochrome oxidase",  EBEC Reports 51, 36-37.
Finel, M., Haltia, T., Puustinen, A., Saraste, M. and Wikström, M. (1990) "Comparison of Structure and Function of Cytochromes aa3 and o in "Structure, Function and Biogenesis of Energy Transfer Systems", (S. Papa et al., eds.), Vol. 28, Elsevier, Amsterdam, 17-20.
Haltia, T. and Wikström, M. (1992): "Cytochrome oxidase: Notes on Structure and Mechanism", in (L. Ernster, ed.) Molecular Mechanisms in Bioenergetics, Chapter 9, pp. 217-239, Elsevier, Amsterdam.
Wikström, M. (1993) "Happi - solujen välttämätön ravinto."Duodecim 109, 2207-2211 ("Oxygen - the necessary fuel of cells"; in Finnish)
Wikström, M. (1996) “Happi - soluhengityksen potentiaalisesti vaarallinen polttoaine” (“Oxygen - the potentially dangerous fuel of cell respiration”; in Finnish), Suomen Lääkärilehti 31, 3215-3216.

Wikström, M. (1997) “Elämän synty ja molekyylien evoluutio” (“The origin of life and the evolution of molecules”; in Finnish), Maailmankuvaa etsimässä (toim. Jan Rydman) WSOY, pp. 221-233.
Wikström, M., Morgan, J.E., Hummer, G., Woodruff, W.H. & Verkhovsky, M.I. (1999) “Oxygen reduction and proton translocation by the haem-copper oxidases”, in (S. Papa, F. Guerrieri & J.M. Tager, eds.) Frontiers of Cellular Bioenergetics: Molecular Biology, Biochemistry and Physiopathology, Plenum Press, New York, pp. 193-217.
Wikström, M. (1999) "Cytochrome c Oxidase", in Embryonic Encyclopedia of Life Sciences, Nature Publishing Group, London, www.els.net.
Wikström, M. (2002) "Oxidative Phosphorylation - An Overview", in Genetics of mitochondrial diseases (Holt, I.J., ed.) Oxford University Press, Oxford, UK, in press.