NUTRIENT SENSING LABORATORY

Selected Publications

Teesalu M, Rovenko BM, Hietakangas V. Salt-Inducible Kinase 3 Provides Sugar Tolerance by Regulating NADPH/NADP+ Redox Balance. Curr Biol. 2017 Feb 6;27(3):458-464.
PubMed

Mattila J*, Havula E*, Suominen E, Teesalu M, Surakka I, Hynynen R, Kilpinen H, Väänänen J, Hovatta I, Käkelä R, Ripatti S, Sandmann T, Hietakangas V. Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Cell Rep. 2015 Oct 13;13(2):350-64.
*Equal contribution
PubMed

Bartok O*, Teesalu M*, Ashwall-Fluss R, Pandey V, Hanan M, Rovenko BM, Poukkula M, Havula E, Moussaieff A, Vodala S, Nahmias Y, Kadener S & Hietakangas V. The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing. EMBO J. 2015 Jun 3;34(11):1538-53.
* Equal contribution
PubMed

Hasygar K, Hietakangas V. p53- and ERK7-dependent ribosome surveillance response regulates Drosophila insulin-like peptide secretion. PLoS Genet. 2014 Nov 13;10(11):e1004764.
PubMed

Havula E, Teesalu M, Hyötyläinen T, Seppälä H, Hasygar K, Auvinen P, Orešič M, Sandmann T & Hietakangas V. Mondo/ChREBP-Mlx-regulated transcriptional network is
essential for dietary sugar tolerance in Drosophila. PLoS Genetics 2013 9:e1003438.
PubMed

Zhang W, Hietakangas V, Lim R, Gunaratne J & Cohen SM. ER stress potentiates insulin resistance through PERK­mediated FOXO phosphorylation. Genes Dev. 2013. 27:441-449.
PubMed

Zhang W, Thompson BJ, Hietakangas V* & Cohen SM*. MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genetics 2011. 7:e1002429.
* Equal contribution.
PubMed

Szuplewski S, Sandmann T, Hietakangas V & Cohen SM. Drosophila Minus is required for cell proliferation and influences Cyclin E turnover. Genes Dev. 2009. 23: 1998-2003.
PubMed

Teleman AA*, Hietakangas V*, Sayadian AC & Cohen SM. Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab. 2008. 7: 21-32.
* Equal contribution.
PubMed

Hietakangas V & Cohen SM. Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev. 2007. 21: 632-637.
PubMed

Review articles

Havula E & Hietakangas V. Glucose sensing by ChREBP/MondoA-Mlx transcription factors. Semin. Cell. Dev. Biol. 2012. 23:640-647.
PubMed

Hietakangas V & Cohen SM. Regulation of tissue growth through nutrient sensing. Annu. Rev. Genet. 2009. 43:389-410.
PubMed

PhD theses

Essi Havula: Transcriptional Control of Dietary Sugar Metabolism and Homeostasis by Mondo-Mlx Transcription Factors
Ethesis

All publications

Contact information

Ville Hietakangas
Group leader, PhD
Associate Professor
Tel. +358 2941 58001
e-mail: ville.hietakangas (at) helsinki.fi

Department of Biosciences (Genetics)
Institute of Biotechnology
P.O.Box. 56, 00014 University of Helsinki
Street address: Viikinkaari 9, Biocenter 1