List of Publications 17/04/2015

Peer-reviewed scientific articles

 

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness.
Katajisto P#, Döhla J, Chaffer CL, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM#.
(#Corresponding author)
Science. 2015 Apr 17;348(6232):340-3.

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.
Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM.
Aging Cell. 2014 Oct;13(5):911-7.

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.
Yilmaz ÖH#, Katajisto P#, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM.
(#Equal contribution)
Nature. 2012 Jun 28;486(7404):490-5

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA.
Science. 2012 Mar 30;335(6076):1638-43

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.
Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J.
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E388-97.

Impaired gastric gland differentiation in Peutz-Jeghers syndrome.
Udd L, Katajisto P, Kyyrönen M, Ristimäki AP, Mäkelä TP.
Am J Pathol. 2010 May;176(5):2467-76.

Lkb1 is required for TGFbeta-mediated myofibroblast differentiation.
Vaahtomeri K, Ventelä E, Laajanen K, Katajisto P, Wipff PJ, Hinz B, Vallenius T, Tiainen M, Mäkelä TP.
J Cell Sci. 2008 Nov 1;121(Pt 21):3531-40.

LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment.
Londesborough A, Vaahtomeri K, Tiainen M, Katajisto P, Ekman N, Vallenius T, Mäkelä TP.
Development. 2008 Jul;135(13):2331-8.

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimäki A, Bardeesy N, Feil R, DePinho RA, Mäkelä TP.
Nat Genet. 2008 Apr;40(4):455-9.

The LKB1 tumor suppressor kinase in human disease.
Katajisto P, Vallenius T, Vaahtomeri K, Ekman N, Udd L, Tiainen M, Mäkelä TP.
Biochim Biophys Acta. 2007 Jan;1775(1):63-75.

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.
Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja SK, Näätsaari L, Karhu A, Westerman AM, Wilson JH, de Rooij FW, Vogel T, Moeslein G, Tomlinson IP, Aaltonen LA, Mäkelä TP, Launonen V.
Br J Cancer. 2005 Mar 28;92(6):1126-9.

Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.
Udd L, Katajisto P, Rossi DJ, Lepistö A, Lahesmaa AM, Ylikorkala A, Järvinen HJ, Ristimäki AP, Mäkelä TP.
Gastroenterology. 2004 Oct;127(4):1030-7.