Research

What drives us

Our aspiration is to decipher the molecular networks involved in stem cell fate acquisition, stem cell maintenance and differentiation.

During development, a complex chain of events regulates cell fate and tissue organization. Within numerous organs stem cells are responsible for the renewal of a part of the organ, insuring its long-term function. Therefore, the formation of renewing organs requires the generation of a niche housing and maintaining the stem cells.

Because of aging, disease, or dramatic events, the organ homeostasis collapses, leading eventually to organ failure. To restore the homeostasis, or to replace the whole organ, the tissue-specific stem cell biology needs to be well comprehended.

To achieve our work, we are combining classical developmental biology strategies and cutting edge molecular and genetic tools. We use the mouse incisor (front tooth), the cornea (transparent surface of the eye) and the lacrimal gland (secreting the tear film) to study the recruitment of the stem cells during organ formation, and their subsequent maintenance and differentiation during the physiological or pathological organ renewal.

The research on stem cells via developmental biology studies helps perfecting regenerative medicine strategies, and we hope that our research will improve human health through a deeper knowledge on stem cell biology