Selected publications

• Buss, H*, Jurrmann, N*, Pekkonen, P*, Beuerlein, K, Muller, H, Handschick, K, Wait, R,Saklatvala, J, Ojala, PM, Schmitz, L, Naumann, M and Kracht, M. Cyclin-dependent kinase 6 phosphorylates NF- k B p65 at serine 536 and contributes to the regulation of inflammatory gene expression. PLoS ONE, 2012, 7(12): e51847. * equal contribution. Read the article
• Santag S, Jäger W, Karsten CB, Kati S, Pietrek M, Steinemann D, Sarek G, Ojala PM , and Schulz TF . Recruitment of the tumour suppressor protein p73 by Kaposi's Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. Oncogene , 2012 Sep 10. doi: 10.1038/onc.2012.385. [Epub ahead of print]. Read the article
• Sarek, G, Ma L, Enbäck, J, Järviluoma, A, Moreau, P, Haas , J, Gessain, A, Koskinen, PJ, Laakkonen, P, and Ojala, PM. Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induces lymphomas. Oncogene 2012 , 2012 Apr 2. [Epub ahead of print]. Read the article
• Cheng F, Pekkonen P, Laurinavicius L, Sugiyama N, Henderson S, Günther T, Rantanen V, Kaivanto E, Aavikko M, Sarek G, Hautaniemi S, Biberfeld P, Aaltonen L, Grundhoff A, Boshoff C, Alitalo K, Lehti K, and Ojala PM. Virus-induced Notch-MT1-MMP axis leads to lymphatic endothelial-to-mesenchymal transition. Cell Host & Microbe , Volume 10, Issue 6 , 577-590, 15 December 2011. Read the article
• Suffert G, Malterer G, Hausser J, Viiliäinen J, Fender A, Contrant M, Ivacevic T, Benes V, Gros F, Voinnet O, Zavolan M, Ojala PM§, Haas JG§, Pfeffer S§. Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis. PLoS Pathogens, 2011 Dec;7(12):e1002405. Epub 2011 Dec 8. § shared correspondence. Read the article
• Tvorogov D, Anisimov A, Zheng W, Leppänen V-M, Tammela T, Laurinavicius S, Holnthoner W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM , and Alitalo K. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell , 2010 Dec 14;18(6):630-40. Epub 2010 Dec 2. Read the article
• Sarek, G, and Ojala P.M.: Restoration of p53 function by MDM2 inhibition as a promising treatment modality for KSHV-associated malignancies. In Molecular Basis for Therapy of AIDS-Defining Cancers, Springer (ed. D. Dittmer & S.Krown), 1st edition, pp. 167-180, 2010
• Sarek G, Järviluoma A, Moore H, Kurki S, Vartia S, Peter Biberfeld, Laiho M and Ojala PM. Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. PLoS Pathogens , 2010 Mar 19;6(3):e1000818. Read the article
• Koskinen P.J., Taipale J., and Ojala P.M. KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PLoS Pathogens , Mar;5(3): e1000324, 2009. Read the article
• Varjosalo M, Björklund M, Cheng F, Syvänen H, Kivioja T, Kilpinen S, Sun Z,
  Kallioniemi O, Stunnenberg HG, He WW, Ojala P, Taipale J. Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell . 2008 May 2;133(3):537-48. Read the article
• Koopal, S., Furuhjelm, J.H., Järviluoma, A., Jäämaa, S., Pyakurel, P.,
  Pussinen, C., Wirzenius, M., Biberfeld, P., Alitalo, K., Laiho, M., and
  Ojala, P.M. 2007: Viral oncogene-induced DNA damage response is activated in
  Kaposi¹s sarcoma tumorigenesis. PLoS Pathog. 2007 Sep 7;3(9):1348-60.
  Read the article
• Sarek, G, and Ojala. P.M. 2007: p53 Reactivation Kills KSHV Lymphomas
  Efficiently In Vitro and In Vivo: New Hope for Treating Aggressive Viral
  Lymphomas. Cell Cycle . Epub 2007 Sep 15. Read the article
• Sarek, G., Kurki, S., Enbäck, J., Iotzova. G., Haas, J., Laakkonen., Laiho,
  M., and Ojala. P.M. 2007: Reactivation of the p53 pathway as a treatment
  modality for KSHV-induced lymphomas. J. Clin. Invest. , Apr 2;117(4):1019-1028. Epub 2007 Mar 15. Read the article
• Jarviluoma A, Ojala PM. Cell signaling pathways engaged by KSHV. Biochim Biophys Acta. 2006 Aug;1766(1):140-58. Epub 2006 May 19. Read the article .
• Jarviluoma A, Child ES, Sarek G, Sirimongkolkasem P, Peters G, Ojala PM,
  Mann DJ. Phosphorylation of the Cyclin-Dependent Kinase Inhibitor p21Cip1 on Serine 130 Is Essential for Viral Cyclin-Mediated Bypass of a p21Cip1-Imposed G1
  Arrest. Mol Cell Biol. 2006 Mar;26(6):2430-40. Read the article
• Sarek G, Jarviluoma A, Ojala PM. KSHV viral cyclin inactivates p27KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas.
  Blood . 2006 Jan 15;107(2):725-32. Epub 2005 Sep 13. Read the article
  

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