Paavilainen Lab

Selected Publications

 

ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons.
Hlushchenko I, Khanal P, Abouelezz A, Paavilainen VO, Hotulainen PE.
Frontiers in Cellular Neuroscience, August 3, 2018

Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature.
Morel JD, Paatero AO, Wei J, Yewdell JW, Guenin-Macé L, Van Haver D, Impens F, Pietrosemoli N, Paavilainen VO, Demangel C.
Mol Cell Proteomics. June 18, 2018

Functional Reconstitution of Human Equilibrative Nucleoside Transporter-1 into Styrene Maleic Acid Co-polymer Lipid Particles.
Rehan S, Paavilainen VO, Jaakola VP.
Biochim Biophys Acta. Feb 27, 2017

Mycolactone subverts immunity by selectively blocking the Sec61 translocon.
Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C.
J Exp Med. Dec 12;213(13):2885-2896, 2016

Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.
Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO.
Cell Chem Biol. May 19;23(5):561-6, 2016

Prolonged and tunable residence time using reversible covalent kinase inhibitors.
Bradshaw JM, McFarland JM, Paavilainen VO, Bisconte A, Tam D, Phan VT, Romanov S, Finkle D, Shu J, Patel V, Ton T, Li X, Loughhead DG, Nunn PA, Karr DE, Gerritsen ME, Funk JO, Owens TD, Verner E, Brameld KA, Hill RJ, Goldstein DM, Taunton J.
Nat Chem Biol. Jul;11(7):525-31, 2015

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.
MacKinnon AL*, Paavilainen VO*, Sharma A, Ramanujan HS, Taunton J
eLife, 3, e01483, 2013 (*equal contribution)

Electrophilic fragment-based design of reversible covalent kinase inhibitors.
Miller RM, Paavilainen VO, Krishnan S, Serafimova IM, Taunton J
J Am Chem Soc. Apr 10;135(14):5298-301, 2013

GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation.
Gandhi M, Smith BA, Bovellan M, Paavilainen V, Daugherty-Clarke K, Gelles J, Lappalainen P, Goode BL.
Curr Biol. 2010 May 11;20(9):861-7, 2010

Structure of the actin-depolymerizing factor homology domain in complex with actin.
Paavilainen VO, Oksanen E, Goldman A, Lappalainen P
J Cell Biol. Jul 14;182(1):51-9, 2008

Missing-In-Metastasis (MIM) and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain like mechanism.
Mattila PK, Pykäläinen A, Saarikangas J, Paavilainen VO, Vihinen H, Jokitalo E, Lappalainen P
J Cell Biol. Mar 26;176(7):953-64, 2007

Structural basis and evolutionary origin of actin filament capping by twinfilin.
Paavilainen VO*, Hellman M*, Helfer E, Bovellan M, Annila A, Carlier M-F, Permi P, Lappalainen P.
Proc Natl Acad Sci U S A. Feb 27;104(9):3113-8, 2007

Biological role and structural mechanism of twinfilin-capping protein interaction.
Falck S, Paavilainen V.O., Wear MA, Grossmann JG, Cooper JA, Lappalainen P.
EMBO J. 2004 Aug 4;23(15):3010-9, 2004

Regulation of cytoskeletal dynamics by actin-monomer-binding proteins.
Paavilainen V.O., Bertling E, Falck S and Lappalainen P
Trends in Cell Biol. 2004 Jul;14(7):386-94, 2004 [Review article]