Contact information

Markku Varjosalo
Tel. +358 2 941 59413
Fax. +358 2 941 59366

e-mail:
markku.varjosalo-at-helsinki.fi

Institute of Biotechnology
P.O.Box. 65
00014 University of Helsinki

Street address:
Viikinkaari 1, Biocenter 3

Publications

Selected Publications

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Yadav L, Tamene F, Göös H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M.
Cell Syst. 2017 Mar 15. pii: S2405-4712(17)30083-2.

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes. Kaustio M, Haapaniemi E, Göös H, Hautala T, Park G, Syrjänen J, Einarsdottir E, Sahu B, Kilpinen S, Rounioja S, Fogarty CL, Glumoff V, Kulmala P, Katayama S, Tamene F, Trotta L, Morgunova E, Krjutškov K, Nurmi K, Eklund K, Lagerstedt A, Helminen M, Martelius T, Mustjoki S, Taipale J, Saarela J, Kere J, Varjosalo M, Seppänen M.
J Allergy Clin Immunol. 2017 Jan 21. pii: S0091-6749(17)30053-2

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry. Heikkinen T, Kämpjärvi K, Keskitalo S, von Nandelstadh P, Liu X, Rantanen V, Pitkänen E, Kinnunen M, Kuusanmäki H, Kontro M, Turunen M, Mäkinen N, Taipale J, Heckman C, Lehti K, Mustjoki S, Varjosalo M, Vahteristo P.
Hum Mutat. 2017 Mar;38(3):269-274.

Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients.Loukovaara S, Nurkkala H, Tamene F, Gucciardo E, Liu X, Repo P, Lehti K, Varjosalo M.
J Proteome Res. 2015 Oct 30.

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity. Turunen M, Spaeth JM, Keskitalo S, Park MJ, Kivioja T, Clark AD, Mäkinen N, Gao F, Palin K, Nurkkala H, Vähärautio A, Aavikko M, Kämpjärvi K, Vahteristo P, Kim CA, Aaltonen LA, Varjosalo M, Taipale J, Boyer TG.
Cell Rep. 2014 May 8;7(3):654-60.

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Varjosalo M, Sacco R, Stukalov A, van Drogen A, Planyavsky M, Hauri S, Aebersold R, Bennett KL, Colinge J, Gstaiger M, Superti-Furga G.
Nat Methods. 2013 Apr;10(4):307-14.

The protein interaction landscape of the human CMGC kinase group.
Varjosalo M, Keskitalo S, Van Drogen A, Nurkkala H, Vichalkovski A, Aebersold R, Gstaiger M.
Cell Rep. 2013 Apr 25;3(4):1306-20.

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Kallioniemi O, Ingvarsen S, Engelholm LH, Taipale J, Alitalo K, Keski-Oja J, Lehti K.
Cancer Res. 2010 Oct 15;70(20):7851-61.

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K.
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15786-91.

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. Cheng F, Weidner-Glunde M, Varjosalo M, Rainio EM, Lehtonen A, Schulz TF, Koskinen PJ, Taipale J, Ojala PM. PLoS Pathog. 2009 Mar;5(3):e1000324.

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Varjosalo M, Björklund M, Cheng F, Syvänen H, Kivioja T, Kilpinen S, Sun Z, Kallioniemi O, Stunnenberg HG, He WW, Ojala P, Taipale J.
Cell. 2008 May 2;133(3):537-48.

Human receptors patched and smoothened partially transduce hedgehog signal when expressed in Drosophila cells.De Rivoyre M, Ruel L, Varjosalo M, Loubat A, Bidet M, Thérond P, Mus-Veteau I.
J Biol Chem. 2006 Sep 29;281(39):28584-95

Identification of pathways regulating cell size and cell-cycle progression by RNAi.
Björklund M, Taipale M, Varjosalo M, Saharinen J, Lahdenperä J, Taipale J.
Nature. 2006 Feb 23;439(7079):1009-13.

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Varjosalo M, Li SP, Taipale J.
Dev Cell. 2006 Feb;10(2):177-86.



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