Selected publications

Original articles

Jussila M, Aalto A, Sanz Navarro M, Shirokova V, Kallonen A, Ohyama T, Groves A, Mikkola ML, Thesleff I. Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning. Development 142: 3954-3963, 2015. (PubMed)

Yang Z, Balic A, Michon F, Juuri E, Thesleff I. Mesenchymal Wnt/β-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10. Stem Cells.  33(5):1670-81. 2015. (PubMed)


Jussila M, Crespo Yanez X, Thesleff I. Initiation of teeth from the dental lamina in the ferret. Differentiation 87:32-43, 2014.

Ahtiainen, L., Lefebvre, S., Lindfors, P.H., Renvoisé, E., Shirokova, V., Vartiainen, M.K., Thesleff, I., Mikkola, M.L., 2014. Directional cell migration, but not proliferation, drives hair placode morphogenesis. Dev. Cell. 28, 588-602. (PubMed)

Juuri E, Jussila M, Seidel K, Holmes S, Wu P, Richman J, Heikinheimo K, Chuong CM, Arnold K, Hochedlinger K, Klein O, Michon F, Thesleff I. Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development 140:1424-1432, 2013. (PubMed)

Jussila, M., Thesleff, I. Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages. In: Signals, switches and networks in mammalian development. Eds. J Rossant, PPL Tam, WJ Nelson, Cold Spring Harb Perspect Biol publ online March 13, 2012.

Shirokova V, Jussila M, Hytönen MK, Perälä N, Drögemüller C, Leeb T, Lohi H, Sainio K, Thesleff I, Mikkola ML. Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes. Dev Dyn.242: 593-603, 2013. (PubMed)

Jernvall, J., Thesleff, I. Tooth shape formation and tooth renewal: evolving with the same signals. Development 139: 3487-97, 2012. (PubMed)

Häärä, O. Harjunmaa, E., Lindfors, P., Huh S-H., Fliniaux, I., Åberg, T., Jernvall J., Ornitz, D.M.., Mikkola, M.L., Thesleff I. Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling. Development 139, 3189-3199, 2012 (PubMed)

Närhi K, Tummers M, Ahtiainen L, Itoh N, Thesleff I, Mikkola ML. Sostdc1 defines the size and number of skin appendage placodes. Dev Biol. 364(2):149-61, 2012. (PubMed)

Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, Klein Od, Thesleff I, Michon F. Sox2+ Stem Cells Contribute to All Epithelial Lineages of the Tooth via Sfrp5+ Progenitors. Dev. Cell 23: 317-328, 2012 (PubMed)

Nieminen P, Morgan NV, Fenwick AL, Parmanen S, Veistinen V, Mikkola ML, Giraud A, Judd L, Arte S, Brueton LA, Wall SA, Maher E, Wilkie AOM, Kreiborg S, Thesleff I. Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption and supernumerary teeth. Am J Hum Genet 89: 67-81, 2011 (PubMed)

Häärä O, Fujimori S, Schmidt-Ullrich R, Hartmann C, Thesleff I, Mikkola ML. Ectodysplasin and Wnt pathways are required for salivary branching morphogenesis. Development 138:2681-91, 2011. (PubMed)

Michon, F, Tummers, M, Kyyrönen, M, Frilander, MJ, Thesleff, I. Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs. Dev. Biol. 340:355-68, 2010. (PubMed)

Närhi, K., Järvinen, E, Birchmeier, W., Taketo, M., M., Mikkola, M.M., Thesleff,I. Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135:1019-1028, 2008 (PubMed)

Wang, X-P., Suomalainen, M, Felszeghy, S., Zelarayan, L.C., Alonso, M.T., Plikus, M.V., Maas, R., Chuong, C-M., Schimmang, T., Thesleff, I. An integrated gene regulatory network controls epithelial stem cell proliferation in teeth. PLoS Biology 5: 1324-1333, 2007. (PubMed)

Pummila, M., Fliniaux, I., Jaatinen, R., James, M., Laurikkala, J., Schneider, P., Thesleff, I., Mikkola, M.L. Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of BMP activity and induction of Shh expression. Development 134: 117-125, 2007. (PubMed)

Järvinen, E., Salazaar-Ciudad, I., Birchmeier, W., Taketo, M.M., Jernvall, J., Thesleff, I. Continuous tooth generation in mouse is induced by activated epithelial Wnt/ ßcatenin signalling. Proc. Natl. Acad. Sci USA 103: 18627-18632, 2006. (PubMed)

Laurikkala, J., Mikkola, M.L., James, M., Tummers, M., Mills, A., Thesleff, I.: P63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation Development 133: 1553-1563, 2006. (PubMed)

Kassai, Y., Munne, P., Hotta, Y., Penttilä, E., Kavanagh, K., Ohbayashi, N., Takada, S., Thesleff, I., Jernvall, J., Itoh, N.: Regulation of mammalian cusp patterning by ectodin. Science 309: 2067-2070, 2005. (PubMed)

Kangas, A.T., Evans, A.R., Thesleff, I., Jernvall, J.: Non-independence of mammalian dental characters. Nature 432: 211-214, 2004. (PubMed)

Wang, X-P., Suomalainen, M., Jorgez, C.j., Matzuk, M.M., Werner, S., and Thesleff, I.: Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signalling and ameloblast differentiation. Dev. Cell 7: 719-730, 2004. (PubMed)

Åberg, T., Wang, X-P., Kim, J-H., Yamashiro, T., Bei, M., Rice, R., Ryoo, H-M., Thesleff, I.: Runx2 mediates FGF signalling from epithelium to mesenchyme during tooth morphogenesis. Dev. Biol. 270: 76-93, 2004. (PubMed)

Lammi, L., Arte, S., Somer, M., Järvinen, H., Lahermo, P., Thesleff, I., Pirinen, S., Nieminen, P.: Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am. J. Hum. Genet. 74: 1043-50, 2004. (PubMed)

Laurikkala, J., Kassai, Y., Pakkasjärvi, L., Thesleff, I., Itoh, N.: Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF and SHH signals from the tooth enamel knot. Dev. Biol. 264: 91-105, 2003. (PubMed)

Mustonen, T. Pummila, M., Kangas, A., Mikkola, M. Pakkasjärvi, L., Pispa, J., Jaatinen, R., Thesleff, I.: Ectodysplasin-A1 stimulates the development of ectodermal organs. Dev. Biol. 253: 123-136, 2003. (PubMed)

Tummers,M. and Thesleff, I.: Root or crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species. Development 130:1049-1057, 2003. (PubMed)

Laurikkala J, Pispa, J., Jung H-S, Nieminen P, Mikkola M, Wang X, Saarialho-Kere U., Galceran, J., Grosschedl, R., Thesleff I. Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar. Development 129:2541-2553, 2002. (PubMed)

Jernvall, J., Keränen, S.V.E., Thesleff, I. Evolutionary modification of development in mammalian teeth: Quantifying gene expression patterns and topography. Proc. Nat. Acad. Sci. USA 97:14444-14448, 2000. (PubMed)

Rice, P., Åberg. T., Chan, Y-S., Kettunen, P., Pakarinen, L., Maxson, R.E., Thesleff,I. Integration of FGF and TWIST in calvarial bone and suture development. Development 127:1845-1855, 2000. (PubMed)

Harada, H., Kettunen, P., Jung, H-S., Mustonen, T., Wang, Y.A., Thesleff, I. Localization of putative stem cells in dental epithelium and their association Notch and FGF signaling. J. Cell Biol. 147:105-120, 1999. (PubMed)

Mikkola, M., Pispa, J., Pekkanen, M., Paulin, L., Nieminen, P., Kere, J., Thesleff, I. Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech. Dev. 88:133-146, 1999. (PDF)

D´Souza, R.N., Åberg, T., Gaikwad, J., Cavender, A., Owen , M., Karsenty, G.,Thesleff, I. Cbfa 1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 126:2911-2920, 1999. (PubMed)

Kim, H-J., Rice, D.P.C., Kettunen, P.J., Thesleff, I. FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development 125:1241-1251, 1998. (PubMed)

Jernvall, J., Åberg, T., Kettunen, P., Keränen, S., Thesleff, I. The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Development 125:161-169, 1998. (PubMed)

Mitsiadis, T.A., Lardelli, M., Lendahl, U., Thesleff, I. Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. J. Cell Biol. 130: 407-418, 1995. (PubMed)

Mitsiadis, T., Muramatsu, T., Muramatsu, H., Thesleff, I. Midkine (MK), a heparing-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis. J Cell Biol. 129: 267-281, 1995. (PubMed)

Jowett, A.K., Vainio, S., Ferguson, M.W.J., Sharpe, P.T., Thesleff,I. Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth. Development 117: 461-470, 1993. (PubMed)

Vainio, S., Karavanova, I., Jowett, A., Thesleff, I. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75: 45-58, 1993. (PubMed)

Reviews and Book Chapters

Thesleff I. The developmental anatomy of teeth. In: Kaufman´s Atlas of Mouse Development. Supplement. Eds. R. Baldock, J. Bard, D.R. Davidson, G. Morriss-Kay. Elsevier/Academic Press.  pp 231- 238. 2016.

Balic A, Thesleff I. Tissue interactions regulating tooth development and renewal. Curr Top Dev Biol. 115:157-86. 2015. (PubMed)

Thesleff I, Juuri E. Dental epithelial stem cells. In: Stem cell biology and tissue engineering in dental sciences. Eds. A. Vishwakarma et al., pp 263-269, Academic Press/Elsevier, 2015

Sariola, H., Frilander, M., Heino, T., Jernvall, J., Partanen, J., Sainio, K., Salminen, M., Thesleff, I., Wartiovaara, K.  Kehitysbiologia: Solusta yksilöksi  (From cell to organism. Developmental Biology).  pp.325 (IT is main author or co-author in 5 of 20 Chapters),  Duodecim, Helsinki, 2015 (Textbook in Finnish language)

Thesleff, I : Current understanding of the process of tooth formation: transfer from the laboratory to the clinic. Aust Dent J 59 Suppl 1:48-54, 2014. (PubMed)

Thesleff, I.  Molecular genetics of tooth development. In “Principles of Developmental Genetics”, 2nd ed. Sally A. Moody. pp. 393-405, Academic Press/Elsevier,  2014.

Jussila, M, Juuri,E., Thesleff, I. Tooth development and regeneration. In : Stem cells in craniofacial development and regeneration. Eds: Huang G T-J and Thesleff I. Wiley-Blackwell, John Wiley & Sons (2013).

Thesleff, I., Juuri, E. Tooth development. In: "Mineralized Tissues in Oral and Craniofacial Science: Biological Principles and Clinical Correlates". Eds LK McCauley, MJ Somerman. pp 119-127, Wiley-Blackwell, 2012.

Jernvall, J., Thesleff, I. Tooth shape formation and tooth renewal: evolving with the same signals. Development 139: 3487-97, 2012. (PubMed)

Jussila, M., Thesleff, I. Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages. In: Signals, switches and networks in mammalian development. Eds. J Rossant, PPL Tam, WJ Nelson, Cold Spring Harb Perspect Biol publ online March 13, 2012. (PubMed)

Thesleff, I, Tummers, M., Tooth organogenesis and regeneration. (January 31, 2009). Stembook, ed. The Stem Book Research Community. StemBook, doi/10.3824/stembook.1.37.1, http://www.stembook.org

Tummers, M., Thesleff, I. The importance of signal pathway modulation in all aspects of tooth development. J Exp Zoolog (Mol Dev Evol) 310B (in press). (301-319), 2009 (PubMed)

Thesleff, I., Järvinen, E., Suomalainen, M. Affecting tooth morphology and renewal by fine-tuning the signals mediating cell and tissue interactions. In “Tinkering: The microevolution of development”, Novartis Found Symp 284: 142-153, 2007. (PubMed)

Thesleff, I. The Teeth. In: “Embryos, Genes and Birth Defects”, eds. P. Ferretti, A. Copp, C. Tickle, G. Moore. pp. 515-535, 2006. John Wiley & Sons, London. (PubMed)

Thesleff, I. The genetic basis of tooth development and dental defects. Am. J. Med. Genet. 140A: 2530-35, 2006. (PubMed)

Wang, X-P, Thesleff, I. Tooth development. In: “Cell Signalling and Growth Factors in Development”. (ed. K. Unsicker and K. Krieglstein). Wiley-VCH , Weinheim, pp. 719-754, 2006.

Thesleff I, Pirinen S: Dental anomalies: Genetics. In: Encyclopedia of life sciences 2005, John Wiley & Sons Ltd., Chichester http://www.els.net/ DOI: 10.1038/npg.els.0006088

Thesleff I, Nieminen, P: Tooth induction. In: Encyclopedia of life sciences, 2005, John Wiley & Sons Ltd., Chichester http://www.els.net/ DOI: 10.1038/npg.els.0004183.

Tummers, M., Thesleff, I.: Epithelial stem cell niche in the tooth. In: Handbook of Stem Cells. Vol. 1 , pp. 265-271, Academic Press, 2004. (PubMed)

Thesleff, I. Epithelial-mesenchymal signalling regulating tooth morphogenesis. J. Cell Sci. 116:1647-1648, 2003. (PubMed)

Pispa, J., Thesleff, I.: Mechanisms of ectodermal organogenesis. Dev. Biol. 262: 195-205, 2003. (PubMed)

Thesleff, I.: Developmental biology and building a tooth. Quintessence Int. 34:613-620, 2003. (PubMed)

Thesleff, I. Molecular genetics of tooth development. In “Principles of Developmental Genetics”, ed. Sally A. Moody. pp. 615-630, Academic Press/Elsevier, 2007. (PubMed)

Thesleff, I., Mikkola, M. The role of growth factors in tooth development. Int. Rev. Cytol. 217:93-135, 2002. (PubMed)

Sahlberg, C., Mustonen, T., Thesleff, I. Explant cultures of embryonic epithelium: analysis of mesenchymal signals. In: Epithelial Cell Culture Protocols. Methods of Molecular Biology. Ed. C. Wise, Humana Press, Totowa, NJ, pp. 373-382, 2002. (PubMed)

Jernvall, J., Thesleff, I. Reiterative signaling and patterning in mammalian tooth morphogenesis. Mech. Dev. 92: 19-29, 2000. (PubMed)