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Functional analysis of the yeast genome: Unknown genes and alpha-galactosidase -encoding MEL genes

Matti Korhola, Ph. D.

Division of General Microbiology
Department of Biosciences
Phone: + 358-9-70859514
Fax: + 358-9-70859515
E-mail:
matti.korhola@helsinki.fi

We participate among over 100 European laboratories in the functional analysis of systematically sequenced 1000 unknown genes of the yeast Saccharomyces cerevisiae (EUROFAN project). Our task is to delete 6 genes and study the effects of the deletions on certain functions of the yeast cell: nutrition, growth, sexual reproduction. We also clone the deleted gene cassettes and the original (cognate) genes for use in international collaboration.

The alpha-galactosidase -encoding MEL gene studies in Saccharomyces yeasts focus on aspects of gene expression, molecular evolution and taxonomy, and yeast physiology.

Personnel

Hilkka Turakainen, Ph. D.; Marja Aittamaa, M. Sc.

Selected publications

Turakainen, H., Aho, S. and Korhola, M. MEL gene polymorphism in the genus Saccharomyces. Appl. Environm. Microbiol., 59: 2622-2630, 1993.

Turakainen, H., Kristo, P. and Korhola, M. Consideration of the evolution of the Saccharomyces cerevisiae MEL gene family on the basis of the nucleotide sequences of the genes and their flanking regions. YEAST, 10: 1559-1568, 1994.

Naumova, E.S., Turakainen, H., Naumov, G.I. and Korhola, M. Superfamily of alpha-galactosidase MEL genes of the Saccharomyces sensu stricto complex. Mol. Gen. Genet., 135: 111-117, 1996.

Paalme, T., Elken, R., Vilu, R. and Korhola, M. Growth efficiency of Saccharomyces cerevisiae on glucose/ethanol media with smooth change in dilution rate (A-stat). Enzyme Microbal. Technol., 20: 174-181, 1997.

Codůn, A.C., Ben&146tez, T. and Korhola, M. Chromosomal polymorphism and adaptation to specific industrial environments of Saccharomyces strains. Appl. Microbiol. Biotechnol., 49, No. 2: 154-163, 1998.

Funding

Alkomohr Biotech Ltd., European Commission, private foundations, Technology Development Centre of Finland (TEKES)

Last update 01.07.1998 Maintained by Jari Ylšnne (ylanne@csc.fi)