University of Helsinki
Faculty of Agriculture and Forestry
 
The Cyanobacteria Group
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Contact information:

Address:
Department of Food and Environment Sciences
Division of Microbiology and Biotechnology
P.O.Box 56
Viikki Biocenter, (Viikinkaari 9)
FIN-00014 Helsinki University
Finland
Fax: +358 2 941 911

LIST OF PUBLICATIONS - updated October 2015

Papers published in international (non-Finnish) scientific journals with referee-system:

Year 2015

Shishido T.K., J. Jokela, C.-T. Kolehmainen, D. P. Fewer, M. Wahslten, H. Wang, L. Rouhiainen, E. Rizzi, G. Debellis, P. Permi and K. Sivonen. 2015. Antifungal activity improved by co-production of cyclodextrins and anabaenolysin in cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America (in press)

Wang, H., K. Sivonen and D. Fewer. 2015. Genomic insights into the distribution, genetic diversity and evolution of polyketide synthases and nonribosomal peptide synthetases. Current Opinion in Genetics & Development (in press).

Humisto, A., L. Herfindal, J. Jokela, A. Karkman, R. Bj?rnstad, R.R. Choudhury and K. Sivonen. 2016. Cyanobacteria as a source for novel anti-leukemic compounds. Current Pharmaceutical Biotechnology, 17(1):78-91.

Dittmann, E., M. Gugger, K. Sivonen and D.P. Fewer. 2015. Review. Natural product biosynthetic diversity and comparative genomics of the cyanobacteria. Trends in Microbiology 23(10):642-652.

Teikari. J., J. ?sterholm, M. Kopf, N. Battchikova, M. Wahlsten, E.-M. Aro, W. R. Hess and K. Sivonen. 2015. Transcriptomics and proteomics profiling of Anabaena sp. strain 90 under inorganic phosphorus stress. Appl.? Environ. Microbiol. 81(15): 5212-5222.

Suurn?kki, S., G. V. Gomez-Saez, A. Rantala-Ylinen, J. Jokela, D. P. Fewer and K. Sivonen. 2015. Identification of geosmin and 2-methylisoborneol in cyanobacteria and molecular detection methods for the producers. Water Research 68:56-66.

Shams, S., C. Capelli, L. Cerasino, A. Ballot, D. R. Dietrich, K. Sivonen, and N. Salmaso. 2015. Anatoxin-a producing Tychonema (Cyanobacteria) in European waterbodies. Water Research 69:68-79.

Shishido, K. T., A. Humisto, J. Jokela, L. Liu, M. Wahlsten, A. Tamrakar, D. P. Fewer, P. Permi, A. P. D. Andreote, M. F. Fiore, and K. Sivonen. 2015. Antifungal compounds from cyanobacteria. Marine Drugs 13(4): 2124-2140.

Liu, L., A. Budnjo, J. Jokela, B. E. Haug, D. P. Fewer, M. Wahlsten, P. Permi, T. Fossen, and K. Sivonen.. 2015. Pseudoaeruginosins, nonribosomal peptides in Nodularia speumigena. ACS Chemical Biology 10(3): 725-733.

Medema, M.H.,? R. Kottmann, P. Yilmaz, M. Cummings, J.B .Biggins, K. Blin, I. de Bruijn, Y. H. Chooi, J. Claesen, R.C. Coates, P. Cruz-Morales, S. Duddela, S. D?sterhus, D.J. Edwards, D.P. Fewer, N. Garg, C. Geiger, J.P. Gomez-Escribano, A. Greule, M. Hadjithomas, A.S. Haines, E.J.N. Helfrich, M.L. Hillwig, K. Ishida, A.C. Jones, C.S. Jones, K. Jungmann, C. Kegler, H.U. Kim, P. K?tter, D. Krug, J. Masschelein, A.V. Melnik, S.M. Mantovani, E.A. Monroe, M. Moore, N. Moss, H.-W. N?tzmann, G. Pan, A. Pati, D. Petras, F.J. Reen, F. Rosconi, Z. Rui, Z. Tian, N.J. Tobias, Y. Tsunematsu, P. Wiemann, E. Wyckoff, X. Yan, G. Yim, F. Yu, Y. Xie, B. Aigle, A.K. Apel, C.J. Balibar, E.P. Balskus, F. Barona-G?mez, A. Bechthold, H.B. Bode, R. Borriss, S.F. Brady, A.A. Brakhage, P. Caffrey, Y.-Q. Cheng, J. Clardy, R.J. Cox, R. De Mot, S. Donadio, M.S. Donia, W.A. van der Donk, P.C. Dorrestein, S. Doyle, A.J.M. Driessen, M. Ehling-Schulz, K.-D. Entian, M.A. Fischbach, L. Gerwick, W.H. Gerwick, H. Gross, B. Gust, C. Hertweck, M. H?fte, S.E. Jensen, J. Ju, L. Katz, L. Kaysser, J.L. Klassen, N.P. Keller, J. Kormanec, O.P. Kuipers, T. Kuzuyama, N.C. Kyrpides, H.-J. Kwon, S. Lautru, R. Lavigne, C.Y. Lee, B. Linquan, X. Liu, W. Liu, A. Luzhetskyy, T. Mahmud, Y. Mast, C. M?ndez, M. Mets?-Ketel?, J. Micklefield, D.A. Mitchell, B.S. Moore, L.M. Moreira, R. M?ller, B.A. Neilan, M. Nett, J. Nielsen, F. O’Gara, H. Oikawa, A. Osbourn, M.S. Osburne, B. Ostash, S.M. Payne, J.-L. Pernodet, M. Petricek, J. Piel, O. Ploux, J.M. Raaijmakers, J.A. Salas, E.K. Schmitt, B. Scott, R.F. Seipke, B. Shen, D.H. Sherman, K. Sivonen, M.J. Smanski, M. Sosio, E. Stegmann, R.D. S?ssmuth, K. Tahlan, C.M. Thomas, Y. Tang, A.W. Truman, M. Viaud, J.D. Walton, C.T. Walsh, T. Weber, G.P. van Wezel, B. Wilkinson, J.M. Willey, W. Wohlleben, G.D. Wright, N. Ziemert, C. Zhang, S.B. Zotchev, R. Breitling, E. Takano and F.O. Gl?ckner. 2015. Minimum information about a biosynthetic gene cluster. Nature Chemical Biology, Vol 11 (September 2015). www.nature.com/naturechemicalbiology

Lynch, F., A. Santana-S?nchez, K. Sivonen, E.-M. Aro, and Y. Allahverdiyeva. 2015. Diversity of native cyanobacteria and green algae for integrated wastewater treatment and biofuel production. Algal Research 11. 411-420. DOI: 10.1016/j.algal.2015.05.015.

Schafhauser, T., D. Wibberg, C. R?ckert, A. Winkler, L. Flor, K.-H. van P?e, D. P. Fewer, K. Sivonen, L. Jahn, J. Ludwig-M?ller, T. Caradec, P. Jacques, M. M.E. Huijbers, W. J.H. van Berkel, T. Weberi, W. Wohlleben, and J. Kalinowski. 2015. Draft genome sequence of Talaromyces islandicus (“Penicillium islandicum”) WF-38-12, a neglected mold with significant biotechnological potential. Journal of Biotechnology 211: 101?102.

Isoj?rvi, J., S. Shunmugam, K. Sivonen, Y. Allahverdiyeva, E.-M. Aro and N. Battchikova. 2015. Draft genome sequence of Calothrix 336/3, novel H2 producing cyanobacterium isolated from Finnish lake. Genome Announcements (genome A) 3(1): e01474-14.

Gkelis, S., T. Lanaras and K. Sivonen. 2015. Cyanobacterial toxic and bioactive peptides in freshwater bodies of Greece: Concentrations, occurrence patterns, and implications for human health. Marine Drugs 13:6319-6335.
Hiltunen, T, Ayan, G.B and Becks, L. 2015 Environmental fluctuations restrict eco-evolutionary dynamics in predator-prey system. Proceedings of the Royal Society B. 282: 20150013.

?rm?l?-Odegrip, A-M., Ojala, V., Hiltunen, T., Zhang, J., Bamford, J. and Laakso, J. 2015 Protist predation can select for bacteria with lowered susceptibility to infection by lytic phages. BMC Evolutionary Biology 15: 8.

Year 2014

Wang, H., D. P. Fewer, L. Holm, L. Rouhiainen and K. Sivonen. 2014. Atlas of nonribosomal peptides and polyketide biosynthetic pathways reveals common occurrence on nonmodular enzymes. Proceedings of the National Academy of Sciences of the United States of America. 111(25): 9259-9264. www.pnas.org/cgi/doi/10.1073/pnas.1401734111.

Wang, H., D. P. Fewer, L. Holm, L. Rouhiainen and K. Sivonen. 2014. Reply to Sasso et al.: Distribution and plylogeny of nonribosomal peptide and polyketide biosynthetic patways in eukaryotes. Proceedings of the National Academy of Sciences of the United States of America 111(38): e3947.

Vestola J., T. K. Shishido, J. Jokela, D. P. Fewer, O. Aitio, P. Permi, M. Wahlsten, H. Wang, L. Rouhiainen, and K. Sivonen. 2014. Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway. Proceedings of the National Academy of Sciences of the United States of America 111(18):E1909-E1917. E doi/10.1073/pnas. 1320913111.

Liu, L., J. Jokela, L. Herfindal, M. Wahlsten, J. Sinkkonen, P. Permi, D. P. Fewer, S. O. D?skeland, and K. Sivonen. 2014. 4-methylproline guided natural product discovery: Co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chemical Biology 9(11): 2646-2655.

Liu, L., L. Herfindal, J. Jokela, T. K. Shishido, M. Wahlsten, S. O. D?skeland and K. Sivonen. 2014. Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Marine Drugs 12: 2036-2053. (doi:10.3390/md12042036).

Liu, L., J. Jokela, M. Wahlsten, B. Nowruzi, P. Permi, Y. Z. Zhang, H. Xhaard, D. P. Fewer, and K. Sivonen. 2014. Nostosins, trypsin inhibitors isolated from the terrestrial cyanobacterium Nostoc sp. strain FSN. Journal of Natural Products 77(8): 1784?1790 dx.doi.org/10.1021/np500106w.

Calteau, A., D. P. Fewer, A. Latifi, T. Coursin, T. Laurent, J. Jokela, C. A. Kerfeld, K. Sivonen, J. Piel and M. Gugger. 2014. Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria. BMC Genomics 15:977.

Kosourov, S., H. Leino, G. Murukesan, F. Lynch, K. Sivonen, A. A. Tsygankov, E-M. Aro and Y. Allahverdiyeva. 2014. Hydrogen photoproduction by immobilized N2-fixing cyanobacteria: Understanding the role of uptake hydrogenase in the long-term process. Appl. Environ. Microbiol. 80(18): 5807-5817.

Leino, H., S. Shunmugam, J. Isoj?rvi, P. Oliveira, P. Mulo, L. Saari, N. Battchikova, K. Sivonen, P. Lindblad, E.-M. Aro and Y. Allahverdiyeva. 2014. Characterization of ten highly H2 producing cyanobacteria isolated from the Baltic Sea and Finnish lakes. International Journal of Hydrogen Energy 39(17):8983?8991.

Shunmugam, S., J. Jokela, M. Wahlsten, N. Battchikova, A. Rehman, I. Vass, M. Karonen, J. Sinkkonen, P. Permi, K. Sivonen, E-A. Aro and Y. Allahverdiyeva. 2014. Secondary metabolite from Nostoc XPORK14A inhibits photosynthesis and growth of Synechocystis PCC 6803. Plant Cell and Environment 37(6): 1371-1381. doi: 10.1111/pce.12243.

Hiltunen, T. and Becks, L. 2014. Consumer co-evolution as an important component of the eco-evolutionary feedback. Nature Communications 6:5226. doi:10.1038/ncomms6226

Ketola, T. and Hiltunen, T. 2014. Rapid evolutionary adaptation to elevated salt concentrations in pathogenic freshwater bacteria Serratia marcescens. Ecology and Evolution 20(4):3901?3908.

Year 2013

Hiltunen, T, and Laakso, J. 2013. The relative importance of competition and predation in environment characterized by resource pulses ? an experimental test with a microbial community. BMC Ecology 13:29 OA

Leikoski, N.,  L. Liu, J. Jokela, M. Wahlsten, M. Gugger, C. Kerfeld, A. Calteau, P. Permi, K. Sivonen and D. P Fewer. 2013. Genome mining expands the chemical diversity of the cyanobactin family to include highly modified linear peptides. Chemistry & Biology 20, 1033–1043.

Fewer, D.P.,  J. Jokela, E. Paukku, J. Österholm, M. Wahlsten, P. Permi, O. Aitio, L. Rouhiainen, G. V. Gomez-Saez, and K. Sivonen. 2013. New structural variants of aeruginosin produced by the toxic bloom forming cyanobacterium Nodularia spumigena. PLoS One. 8(9):e73618. doi: 10.1371/journal.pone.0073618.

Fewer, D. P., M. Wahlsten, J. Österholm, J. Jokela, L. Rouhiainen, U. Kaasalainen, J. Rikkinen, and K. Sivonen. 2013. The genetic basis for O-acetylation of the microcystin toxin in cyanobacteria. Chemistry & Biology 20: 861-869.

Dittmann, E., D.P. Fewer and B.A. Neilan. 2013. Cyanobacterial toxins: Biosynthetic routes and evolutionary roots. FEMS Microbiology Reviews 37: 23–43.

Kapuscik,A., P. Hrouzek, M. Kuzma, S. Bartová, P. Novak, J. Jokela, M. Pflüger, A. Eger, H. Hundsberger and J. Kopecký. 2013. A novel aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent. ChemBioChem 14, 2329-2337, DOI: 10.1002/cbic.201300246.

Sinkko H., K. Lukkari, L. M. Sihvonen, K. Sivonen, M. Leivuori, M. Rantanen, L. Paulin and C. Lyra. 2013. Bacteria contribute to sediment nutrient release and reflect progressed eutrophication-driven hypoxia in an organic-rich continental sea. PLoS ONE  8(6): e67061.

Shishido, T.K., U. Kaasalainen, D. P. Fewer, L. Rouhiainen, J. Jokela, M. Wahlsten, M. de Fátima Fiore, J. S. Yunes, J. Rikkinen and K. Sivonen. 2013. Convergent evolution of [D-Leucine1] microcystin-LR in taxonomically disparate cyanobacteria. BMC Evolutionary Biology 13:86. DOI: 10.1186/1471-2148-13-86.

Voß, B., H. Bolhuis, D. P. Fewer, M. Kopf, F. Möke, F. Haas, R. El-Shehawy, P. Hayes, B. Bergman, K. Sivonen, E. Dittmann, D. J. Scanlan, M. Hagemann, L. J. Stal, and W. R. Hess. 2013. Insights into the physiology and ecology of the brackish-water-adapted cyanobacterium Nodularia spumigena CCY9414 based on a genome-transcriptome analysis. PLoS ONE 8(3): e60224. doi:10.1371/journal.pone.0060224.

Kaasalainen, U., D. Fewer, J. Jokela, M. Wahlsten. K. Sivonen and J. Rikkinen. 2013. Lichen species identity and diversity of cyanobacterial toxins in symbiosis. New Phytologist 198(3): 647-651.

Nowruzi, B., R.A. Khavari-Nejad, K. Sivonen, B. Kazemi, F. Najafi and T. Nejadsattari. 2013. Optimization of cultivation conditions to maximize extracellular investments of the Nostoc Strains. Algological Studies 142: 63-76.

Shunmugam, S., R. Hinttala, N. Lehtimäki, M. Miettinen, J. Uusimaa, K. Majamaa, K. Sivonen, E.-M. Aro, and P. Mulo. 2013. Nodularia spumigena induces upregulation of mitochondrial respiratory chain complexes in spinach (Spinacia oleracea L.). Acta Physiologiae Plantarum (in press) Published on line 16 October 2012, doi: 10.1007/s11738-012-1119-3.

Shih, PM., Wu D, Latifi A, Axen SD, Fewer DP, Talla E, Calteau A, Cai F, Tandeau de Marsac N, Rippka R, Herdman M, Sivonen K, Coursin T, Laurent T, Goodwin L, Nolan M, Davenport KW, Han CS, Rubin EM, Eisen JA, Woyke T, Gugger M, Kerfeld CA. 2013. Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing. Proceedings of the National Academy of Sciences of the United States of America 110(3): 1053-1058.

Arnison, P.G.,  M. J. Bibb,  G. Bierbaum, A. A. Bowers, T. S. Bugni,  G. Bulaj, J. A. Camarero, D. J. Campopiano,  G. L. Challis,  J. Clardy, P. D. Cotter, D. J. Craik, M. Dawson, E. Dittmann, S. Donadio, P. C. Dorrestein, K.-D. Entian, M. A. Fischbach, J. S. Garavelli, U. Göransson, C. W. Gruber, D. H. Haft, T. K. Hemscheidt, C. Hertweck, C. Hill, A. R. Horswill, M. Jaspars, W. L. Kelly, J. P. Klinman, O. P. Kuipers, A. J. Link, W. Liu, M. A. Marahiel, D. A. Mitchell, G. N. Moll, B. S. Moore, R. Mueller, S. K. Nair, I. F. Nes, G. E. Norris, B. M. Olivera, H. Onaka, M. L. Patchett, J. Piel, M. J. T. Reaney, S. Rebuffat, R. P. Ross, H.-G. Sahl, E. W. Schmidt, M. E. Selsted, K. Severinov, B. Shen, K. Sivonen, L. Smith, T. Stein, R. E. Suessmuth, J. R. Tagg, G.-L. Tang, A. W. Truman, J. C. Vederas, C. T. Walsh, J. D. Walton, S. C. Wenzel, J. M. Willey and W. A. van der Donk. 2013. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. A Review in Natural Product Reports 30:108-160.

Year 2012

Wang, H., K. Sivonen, L. Rouhiainen, D. P. Fewer, C. D. Lyra, A. Ylinen, J. Vestola, J. Jokela, K. Rantasärkkä, Z. Li and B. Liu. 2012. Genome derived insights into the biology of the hepatotoxic bloom forming cyanobacterium Anabaena sp. strain 90. BMC Genomics 13(1): 613.

Kaasalainen, U., D. P. Fewer, J. Jokela, M. Wahlsten, K. Sivonen and J. Rikkinen. 2012. Cyanobacteria produce a high variety of hepatotoxic peptides in lichen symbiosis. Proceedings of the National Academy of Sciences of the United States of America 109(15): 5886-5891.

Jokela, J., L. Oftedal, L. Herfindal, P. Permi, M. Wahlsten, S. O. Døskeland and K. Sivonen. 2012. Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria. PLoS ONE 7(7): e41222. doi:10.1371/journal.pone.0041222.

Oftedal, L.,l, L. Myhren, J. Jokela, G. Gausdal, K. Sivonen, S. O. Døskeland and L. Herfindal.  2012. The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol dependent manner. Biochimica et Biophysica Acta 1818:  3000–3009. (http://dx.doi.org/10.1016/j.bbamem.2012.07.015)

Leikoski, N., D. P. Fewer, J. Jokela, P. Alakoski, M. Wahlsten and K. Sivonen. 2012. Analysis of an inactive cyanobactin biosynthetic gene cluster leads to discovery of new natural products from strains of the genus Microcystis. PLoS ONE 7(8): e43002. doi:10.1371/journal.pone.0043002.

Simola, O., M. Wiberg, J. Jokela, M. Wahlsten, K. Sivonen and P. Syrjä. 2012. Pathological findings and identification of the toxin in acute cyanobacterial (Nodularia spumigena) intoxication in a dog. Veterinary Pathology 49: 755-759.

Leino, H., S. N. Kosourov, L. Saari, K. Sivonen,  A. A. Tsygankov, E.-A., Aro, and  Y. Allahverdiyeva. 2012. Extended H2 photoproduction by N2-fixing cyanobacteria immobilized in thin alginate films. International Journal of Hydrogen Energy 37:151-161.

Year 2011

Rantala-Ylinen, A., S. Känä, H. Wang, L. Rouhiainen, M. Wahlsten, E. Rizzi, K. Berg, M. Gugger and K. Sivonen. 2011. Anatoxin-a synthetase gene cluster of the cyanobacterium Anabaena strain 37 and molecular methods to detect potential producers. Appl. Environ. Microbiol. 77:7271-7278.

Wang, H., D. P. Fewer and K. Sivonen. 2011. Genome mining demonstrates the widespread occurrence of gene clusters encoding bacteriocins in cyanobacteria. PLoS ONE 6(7): e22384.

Fewer, D. P., K. Halinen, H. Sipari, K. Bernardová, M. Mänttäri, E. Eronen and K. Sivonen. 2011. Non-autonomous transposable elements associated with inactivation of microcystin gene clusters in strains of the genus Anabaena isolated from the Baltic Sea. Environ. Microbiol. Reports 3(2): 189-194.

Herfindal, L., L. Myhren, R. Kleppe, C. Krakstad, F. Selheim, J. Jokela, K. Sivonen, and S. O. Døskeland. 2011. Nostocyclopeptide-M1: a potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and 1B1. Molecular Pharmaceutics 8(2): 360-367.

Fewer, D. P., J. Österholm, L. Rouhiainen, J. Jokela, M. Wahlsten and K. Sivonen. 2011. Nostophycin biosynthesis is directed by a hybrid polyketide synthase-nonribosomal peptide synthetase in the toxic cyanobacterium Nostoc sp. strain 152. Appl. Environ. Microbiol. 77: 8034-8040.

Kolmonen, E., K. Haukka, A. Rantala-Ylinen, P. Rajaniemi-Wacklin, L. Lepistö and K. Sivonen. 2011. Bacterioplankton community composition of 67 Finnish lakes differing in trophic status. Aquatic Microbial Ecology 62: 241-250.

Lehtimäki, N., S. Shunmugam, J. Jokela, M. Wahlsten, D. Carmel, M. Keränen, K. Sivonen, E.-M. Aro and P. Mulo. 2011. Nodularin uptake and induction of oxidative stress in spinach (Spinachia oleracea). Journal of Plant Physiology 168(6):594-600.

Sinkko H., K. Lukkari, A. S. Jama, L. M. Sihvonen, K. Sivonen, M. Leivuori, M. Rantanen, L. Paulin and C. Lyra. 2011. Phosphorus chemistry and bacterial community composition interact in brackish sediments receiving agricultural discharges. PLoS ONE 6(6): e21555.

Berg, K. A., C. Lyra, R. M. Niemi, B. Heens, K. Hoppu, K. Erkomaa, K. Sivonen, and J. Rapala. 2011. Virulence genes of Aeromonas isolates, bacterial endotoxins and cyanobacterial toxins from recreational water samples associated with human health symptoms. Journal of Water and Health 9(4): 670-679.

Year 2010

Rouhiainen, L., J. Jokela, D. P. Fewer, M. Urmann and K. Sivonen. 2010. Two alternative starter modules for the non-ribosomal biosynthesis of specific anabaenopeptin variants in Anabaena (Cyanobacteria). Chemistry & Biology 17: 265-273.

Leikoski, N., D. P. Fewer, J. Jokela, M. Wahlsten, L. Rouhiainen and K. Sivonen. 2010. Highly diverse cyanobactins in strains of the genus Anabaena. Appl. Environ. Microbiol. 76: 701-709.
Sivonen, K., N. Leikoski, D.P. Fewer and J. Jokela. 2010. Cyanobactins - cyclic ribosomal peptides produced by cyanobacteria. A mini-review. Applied Microbiology and Biotechnology 86(5): 1213-1225.

Sipari, H., A. Rantala-Ylinen, J. Jokela, I. Oksanen, and K. Sivonen. 2010. Development of a chip assay and qPCR for detecting microcystin synthetase gene E expression. Appl. Environ. Microbiol. 76(12): 3797-3805.

Jokela, J., L. Herfindal, M. Wahlsten, P. Permi, V. Vasconçelos, S. O. Døskeland, and K. Sivonen. 2010. A novel nostocyclopeptide inhibits microcystin and nodularin induced apoptosis in hepatocytes. ChemBioChem 11: 1594-1599.

Oftedal, L., F. Selheim, M. Wahlsten, K. Sivonen, S. O. Døskeland and L. Herfindal. 2010. Marine benthic cyanobacteria contain apoptosis-iducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes. Marine Drugs 8: 2659-2672.


Allahverdiyeva, Y., H. Leino, L. Saari, D.P. Fewer, S. Shunmugam, K. Sivonen and E.-A. Aro. 2010. Screening for biohydrogen production by cyanobacteria isoletad from the Baltic Sea and Finnish lakes. International Journal of Hydrogen Energy 35: 1117-1127.

Year 2009

Fewer, D. P., J. Jokela, L. Rouhiainen, M. Wahsten, K. Koskenniemi, L. J. Stal, and K. Sivonen 2009. The non-ribosomal assembly and frequent occurrence of the protease inhibitors spumigins in the bloom-forming cyanobacterium Nodularia spumigena. Molecular Microbiology 73: 924-937.

Berg, K.A., C. Lyra, K. Sivonen, L. Paulin, S. Suomalainen, P. Tuomi and J. Rapala. 2009. High diversity of cultivable heterotrophic bacteria in association with cyanobacterial water blooms. ISME Journal 3: 314-325.

Leikoski, N., D. P. Fewer and K. Sivonen. 2009. Widespread occurrence and lateral gene transfer of the cyanobactin biosynthetic gene cluster in cyanobacteria. Appl. Environ. Microbiol. 75(3): 853-857.

Fewer, D. P., M. Köykkä, K. Halinen, J. Jokela, C. Lyra and K. Sivonen. 2009. Culture-independent evidence for the persistent presence and genetic diversity of microcystin-producing Anabaena (Cyanobacteria) in the Gulf of Finland. Environmental Microbiology 11(4): 855-866.

Kaasalainen, U., J. Jokela, D. P. Fewer, K. Sivonen and J. Rikkinen. 2009. Microcystin production in the tripartite cyanolichen Peltigera leucophlebia. Molecular Plant-Microbe Interactions 22: 695-702.

Herfindal, L., F. Kasprzykowski, F. Schwede, L. Łankiewicz, K. Fladmark, J. Łukomska, M. Wahlsten, K. Sivonen, Z. Grzonka, B. Jastorff, and S. O. Døskeland. 2009. Acyloxymethyl-esterification of nodularin and microcystin produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. Journal of Medicinal Chemistry 52: 5758-5762.

Galkin, A., J. Jokela, M. Wahlsten, P. Tammela, K. Sivonen and P. Vuorela. 2009. Discovering protein kinase C active plants growing in Finland with automated bioassay combined to LC/MS. Natural Product Communications 4(1): 139-142.


Year 2008

Rantala, A., Rizzi, E., B., Castiglioni, G. de Bellis and K. Sivonen. 2008. Identification of hepatotoxin-producing cyanobacteria by DNA-chip. Environmental Microbiology 10(3): 653-664.

Fewer, D.P., A. Tooming-Klunderud, J. Jokela, M. Wahlsten, L. Rouhiainen, T. Kristensen, T. Rohrlack, K. Jakobsen and K. Sivonen. 2008. Natural occurrence of microcystin synthetase deletion mutants capable of producing microcystins in strains of genus Anabaena (cyanobacterium). Microbiology 154: 1007-1014.

Halinen, K., D. P. Fewer, L. M. Sihvonen, C. Lyra, E. Eronen and K. Sivonen. 2008. Genetic diversity in strainsof the genus Anabaena isolated from planktonic and benthic habitats of the Gulf of Finland (Baltic Sea). FEMS Microbiology Ecology 64: 199-208.

Rajaniemi, P., A. Rantala, K. Haukka, P. Kuuppo, L. Lepistö, and K. Sivonen. 2008. Cyanobacterial community composition in shallow, eutrophic Lake Tuusulanjärvi studied by microscopy, strain isolation, DGGE and cloning. Algological Studies 126: 137-157.

Johansson, S., S. Vintila, K. Sivonen and R. El-Shehawy. 2008. Expression of the nodularin synthetase genes in the Baltic Sea bloom-former cyanobacterium Nodularia spumigena strain AV1. FEMS Microbiology Ecology 65: 31-39.

Tooming-Klunderud, A., D. P. Fewer, T. Rohrlack, J. Jokela, L. Rouhiainen, K. Sivonen, T. Kristensen and K. S. Jakobsen. 2008. Evidence for positive selection acting on microcystin synthetase adenylation domains in three cyanobacterial genera. BMC Evolutionary Biology 8: 256.

Galkin, A., A. Surakka, G. Boije af Gennäs, T. Ruotsalainen, K. Kreander P. Tammela, J. Yli-Kauhaluoma, K. Sivonen and P. Vuorela. 2008. Hydrophobic derivatives of 5-(hydroxymethyl)isophthalic acid that selectively induce apoptosis in leukaemia cells but not in fibroblasts. Drug Develoment Research 69(4): 185-195.

Year 2007

Koskenniemi, K., C. Lyra, P. Rajaniemi-Wacklin, J. Jokela and K. Sivonen. 2007. A quantitative real-time PCR detection of toxic Nodularia (cyanobacteria) in the Baltic Sea. Appl. Environ. Microbiol. 73:2173-2179.

Sivonen, K., K. Halinen, L. M. Sihvonen, K. Koskenniemi, H. Sinkko, K. Rantasärkkä, P. Moisander and C. Lyra. 2007. Bacterial diversity and function in the Baltic Sea with an emphasis on cyanobacteria. AMBIO, XXXVI (2-3): 180-185.

Fewer, D.P., L. Rouhiainen, J. Jokela, H. Wang, M. Wahlsten, K. Laakso and K. Sivonen. 2007. Recurrent adenylation domain replacement in the microcystin synthetase gene cluster. BMC Evolutionary Biology 7:183 (open access journal).

Sihvonen, L. M., C. Lyra, D. P. Fewer, P. Rajaniemi-Wacklin, J. M. Lehtimäki, M. Wahlsten, and K. Sivonen. 2007. Strains of the cyanobacterial genera Calothrix and Rivularia isolated from the Baltic Sea display cryptic diversity and are distantly related to Gloeotrichia and Tolypothrix. FEMS Microbiology Ecology 61: 74-84.


Halinen, K., J. Jokela, D. Fewer, M. Wahlsten and K. Sivonen. 2007. Direct evidence for the production of microcystins by strains of the genus Anabaena (Cyanobacteria) isolated from the Baltic Sea. Appl. Environ. Microbiol. 73: 6543-6550.

Lagus, A., J. Suomela, H. Helminen, J.M. Lehtimäki, J. Sipura, K. Sivonen and L. Suominen. 2007. Interaction effects of N:P ratios and the frequency of nutrient supply on the plankton community in the northern Baltic Sea. Marine Ecology Progress Series 332:77-92.

Schober, E., M. Werndl, K. Laakso, I. Korschineck, K. Sivonen and R. Kurmayer. 2007. Interlaboratory comparison of Taq Nuclease Assay for the quantification of the toxic cyanobacteria Microcystis sp. Journal of Microbiological Methods 69:122-128.


Moisander, P. H., H. W. Paerl, J. Dyble, and K. Sivonen. 2007. Phosphorus limitation and diel control of nitrogen-fixing cyanobacteria in the Baltic Sea. Marine Ecology Progress Series 345: 41-50.

Year 2006

Rantala, A., P. Rajaniemi-Wacklin, C. Lyra, L. Lepistö, J. Rintala, J. Mankiewicz-Boczek and K. Sivonen. 2006. Detection of microcystin-producing cyanobacteria in Finnish lakes with genus-specific microcystin synthetase gene E (mcyE) PCR and associations with environmental factors. Appl. Environ. Microbiol. 72:6101-6110.

Rajaniemi P., M. Mugnai, A. Rantala, S. Turiccia, S. Ventura, J. Komarkova, L. Lepistö and K. Sivonen. 2006. Correspondence between phylogeny and morphology of Snowella spp. and Woronichinia naegeliana, cyanobacteria commonly occurring in lakes. Journal of Phycology 42:226-232.

Niva, M., A. Hernesmaa, K. Haahtela, M. Salkionja-Salonen, K. Sivonen and K. Haukka. 2006. Actinobacterial communities of boreal forest soil and lake water are rich in mycobacteria. Boreal Environ. Res. 11:45-53.

Haukka, K., E. Kolmonen, R. Hyder, J. Hietala, K. Vakkilainen, T. Kairesalo, H. Haario and K. Sivonen. 2006. Effect of nutrient loading on bacterioplankton community composition in lake mesocosms. Microbial Ecology 51:137-146.

Gkelis, S., T. Lanaras and K. Sivonen. 2006. The presence of microcystins and other cyanobacterial bioactive peptides in aquatic fauna collected from Greek freshwaters. Aquatic Toxicology 78:32-41.

Suikkanen, S., J. Engström-Öst, J. Jokela, K. Sivonen and M. Viitasalo. 2006. Allelopathy of Baltic Sea cyanobacteria: no evidence for the role of nodularin. Journal of Plankton Research 28(6):543-550.

Year 2005

Rajaniemi P., P. Hrouzek, K. Kaštovská, R. Willame, A. Rantala, L. Hoffmann, J. Komárek and K. Sivonen. 2005. Phylogenetic and morphplogical evaluation of the genera Anabaena, Aphanizomenon, Trichormus and Nostoc (Nostocales, cyanobacteria). Int. J. System. Evol. Microbiol. 55:11-26.

Lyra, C., M. Laamanen, J. M. Lehtimäki, A. Surakka and K. Sivonen. 2005. Benthic cyanobacteria of the genus Nodularia are non-toxic, without gas vacuoles, able to glide and genetically more diverse than planktonic Nodularia. Int. J. System. Evol. Microbiol. 55:555-568.

Haukka, K., E. Heikkinen, T. Kairesalo, H. Karjalainen, K. Sivonen. 2005. The effect of humic material on the bacterioplankton community composition in boreal lakes and mesocosms. Environmental Microbiology 7(5):620-630.

Gkelis, S., P. Rajaniemi, E. Vardaka, M. Moustaka, T. Lanaras and K. Sivonen. 2005. Limnothrix redekei (van Goor) Meffert (cyanobacteria) strains from Lake Kastoria Greece form a separate phylogenetic group. Microbial Ecology 48(4):350-358.

Gkelis, S., V. Harjunpää, T. Lanaras and K. Sivonen. 2005. Diversity of hepatotoxic microcystins and bioactive anabaenopeptins in cyanobacterial blooms from Greek freshwaters. Environ. Toxicol. 20:249-256.

Surakka, A., L. M. Sihvonen, J. M. Lehtimäki, M. Wahlsten, P., Vuorela and K. Sivonen. 2005. Benthic cyanobacteria from the Baltic Sea contain cytotoxic Anabaena, Nodularia and Nostoc strains and an apoptosis inducing Phormidium strain. Environ. Toxicol. 20:285-292.

Karjalainen, M., M. Reinikainen, L. Spoof, J. A. O. Meriluoto, K. Sivonen and M. Viitasalo. 2005. Trophic transfer of cyanobacterial toxins from zooplankton to planktivores: consequences to pike larvae and mysid shrimps. Environ. Toxicol. 20:354-362.

Kaartokallio, H., M. Laamanen and K. Sivonen. 2005. Responses of Baltic Sea ice and open-water natural bacterial communities to salinity change. Appl. Environ. Microbiol. 71(8):4364-4371.

Herfindal, L., L. Oftedal, F. Selheim, M. Wahlsten, K. Sivonen and S. O. Døskeland. 2005. A high proportion of Baltic Sea bentic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes. Toxicon 46:252-260.

Effect of nutrient enrichment on bacterioplankton biomass and community composition in mesocosms in the Archipelago Sea, northern Baltic. Journal of Plankton Research 27(12):1261-1272.

Geliks, S., M. Moustaka-Gouni, K. Sivonen, and T. Lanaras. 2005. First report of the cyanobacterium Aphanizomenon ovalisporum Forti in two Greek lakes and cyanotoxin occurrence. Journal of Plankton Research 27(12):1295-1300.

Year 2004

Rantala, A., D. P. Fewer, M. Hisbergues, L. Rouhiainen, J. Vaitomaa, T. Börner and K. Sivonen. 2004. Phylogenetic evidence for the early evolution of microcystin synthesis. Proceedings of the National Academy of Sciences of the United States of America 101(2): 568-573.

Rouhiainen, L., T. Vakkilainen, B. Lumbye Siemer, W. Buikema, R. Haselkorn, and K. Sivonen. 2004. Genes coding for hepatotoxic heptapeptides (microcystins) in the cyanobacterium Anabaena strain 90. Appl. Environ. Microbiol. 70(2):686-692.

Oksanen, I., K. Lohtander, K. Sivonen and J. Rikkinen. 2004. Repeat type distribution in trnL intron does not correspond with species phylogeny; comparison of the genetic markers 16S rRNA and trnL intron in heterocystous cyanobacteria. Int. J. System. Evol. Microbiol. 54:765-772.

Repka, S., M. Koivula, V. Harjunpää, L. Rouhiainen and K. Sivonen. 2004. Effects of phosphate and light on growth of and bioactive peptide production by the cyanobacterium Anabaena strain 90 and its anabenopeptilide mutant. Appl. Environ. Microbiol. 70(8):4551-4560.

Repka, S., M. Meyerhöfer, K. von Bröckel and K. Sivonen. 2004. Associations of cyanobacterial toxin, nodularin, with environmental factors and zooplankton in the Baltic Sea. Microbial Ecology 47:350-358.

Kolmonen, E., K. Sivonen, J. Rapala and K. Haukka. 2004. Diversity of cyanobacteria and heterotrophic bacteria in cyanobacterial blooms in Lake Joutikas, Finland. Aquatic Microbial Ecology 36:201-211.

Oksanen, I., J. Jokela, D. Fewer, M. Wahlsten, J. Rikkinen and K. Sivonen. 2004. Discovery of rare and higly toxic microcystins from lichen associated cyanobacterium Nostoc sp. strain IO-102-I. Appl. Environ. Microbiol. 70:5756-5763.

Castiglioni, B., E. Rizzi, A. Frosini, K. Sivonen, P. Rajaniemi, A. Rantala, M. A. Mugnai, S. Ventura, A. Wilmotte, C. Boutte, S. Grubisic, P. Balthasart, C. Consolandi, R. Bordoni, A. Mezzelani, C. Battaglia and G. De Bellis. 2004. Development of a universal microarray based on the ligation detection reaction and 16S rRNA gene polymorphism to target diversity of cyanobacteria. Appl. Environ. Microbiol. 70(12):7161-7172.

Year 2003

Vaitomaa, J., A. Rantala, K. Halinen, L. Rouhiainen, P. Tallberg, L. Mokelke and K. Sivonen. 2003. Quantitative real-time-PCR for determination of of microcystin synthetase E copy numbers for Microcystis and Anabaena in lakes. Appl. Environ. Microbiol. 69(12):7289-7297.

Stal, L. J., P. Albertano, B. Bergman, K. von Bröckel, J. R. Gallon, P. K. Hayes, K. Sivonen and A. E. Walsby. 2003. BASIC: Baltic Sea cyanobacteria. An investigation of the structure and dynamics of water blooms of cyanobacteria in ttheBaltic Sea – responses to a changing environment. Continental Shelf Research 23:1695-1714.

Hisbergues, M., G. Christiansen, L. Rouhiainen. K. Sivonen and T. Börner. 2003. PCR-based identification of microcystin-producing genotypes of different cyanobacterial genera. Arch. Microbiol. 180:402-410.

Year 2002

Gugger, M., C. Lyra, I. Suominen, I. Tsitko, J.-F. Humbert, M. Salkinoja-Salonen and K. Sivonen. 2002. Cellular fatty acids as chemotaxonomic markers of the genera Anabaena, Aphanizomenon, Microcystis, Nostoc and Planktothrix (cyanobacteria). Int. J. System. Evol. Microbiol. 52:1007-1015.

Laamanen, M., L. Forsström and K. Sivonen. 2002. Diversity of Aphanizomenon flos-aquae (cyanobacteria) populations along a Baltic Sea salinity gradient. Appl. Environ. Microbiol. 68:5296-5303.

Gugger, M., C. Lyra, P. Henriksen, A. Couté, J.-F. Humbert and K. Sivonen. 2002. Morphological and molecular comparison of the cyanobacterial genera Anabaena and Aphanizomenon. Int. J. Syst. Evol. Microbiol. 52:1867-1880.

Gugger, M., C. Lyra, P. Henriksen, A. Couté, J.-F. Humbert and K. Sivonen. 2002. Morphological and molecular comparison of the cyanobacterial genera Anabaena and Aphanizomenon. Int. J. Syst. Evol. Microbiol. 52:1867-1880.

Engström-Öst, J., M. Koski, K. Schmidt, M. Viitasalo, S. H. Jónasdóttir, M. Kokkonen, S. Repka and K. Sivonen. 2002. Effects of toxic cyanobacteria on a plankton assemblage: community development during decay of Nodularia spumigena. –Mar. Ecol. Prog. Ser., 232:1-14.

Reinikainen, M., F. Lindvall, J.A.O. Meriluoto, S. Repka, K. Sivonen, L. Spoof and M. Wahlsten. 2002. Effects of cyanobacterial toxins on the survival and egg-hatching of estuarine calanoid copepods. Marine Biology 140:577-583.

Koski, M., K. Schmidt, J. Engström-Öst, M. Viitasalo, S. Jónasdottir, S., Repka and K: Sivonen. 2002. Calanoid copepods feed and reproduce eggs in the presence of toxic cyanobacteria Nodularia spumigena. Limnol. Oceanogr. 47(3):878-885.

Hietanen, S., J. M. Lehtimäki, L. Tuominen, K. Sivonen and J. Kuparinen. 2002. Nodularia spp. (cyanobacteria) incorporate leucine but not thymidine; importance for bacterial production measurements. Aquatic Microbial Ecology 28:99-104.

Rapala, J. K. Lahti, L. A. Räsänen, L. A. Esala, S. I. Niemelä and K. Sivonen. 2002. Endotoxins associated with cyanobacteria and their removal during drinking water treatment. Water Research 36:2627-2635.

Vézie, J. Rapala, J. Vaitomaa, J. Seitsonen and K. Sivonen. 2002. Effect of nitrogen and phosphorus on growth of toxic and non-toxic Microcystis strains and on intracellular microcystin concentrations. Microbial Ecology 43:443-454.

Rapala, J., K. Erkomaa, J. Kukkonen, K. Sivonen & K. Lahti. 2002. Detection of microcystins with protein phosphatase inhibition assay, high-performance liquid chromatography-UV detection and enzyme-linked immunosorbent assay. Comparison of methods. Analytica Chimica Acta 466:213-231.

Gallon, J., A. M. Evans, A. Jones, P. Albertano, R. Congestri, B. Bergman, K. Gundersen, K. M. Orcutt, K. von Bröckel, P. Fritsche, M. Meyerhöfer, K. Nachtigall, U. Ohlendieck, S. te Lintel Hekkert, K. Sivonen, S. Repka, L. J. Stal and M. Staal. 2002. Maximum rates of N2 fixation and primary production are out of phase in a developing cyanobacterial bloom in the Baltic Sea. Limnol. Oceanogr. 47:1514-1521.

Vaitomaa, J. S. Repka, L. Saari, P. Tallberg, J. Horppila and K. Sivonen. 2002. Aminopeptidase and phosphatase activities in basins of Lake Hiidevesi dominated by cyanobacteria and in laboratory grown Anabaena. Freshwater Biology 47:1582-1593.

Fujii, K., K. Sivonen, T. Nakano and K.-I. Harada. 2002. Structural elucidation of cyanobacterial peptides encoded by peptide synthetase gene in Anabaena species. Tetrahedron 58:6863-6871.

Castiglioni, B., E. Rizzi, A. Frosini, M. A. Mugnai, S. Ventura, K. Sivonen, P. Rajaniemi, A. Rantala, A. Wilmotte, C. Boutte, C. Consolandi, R. Bordoni, A. Mezzelani, E. Busti, L. Rossi, Bernardi, C. Battaglia and G. De Bellis. 2002. Application of an universal DNA microarray to cyanobacterial diversity assessment. Minerva Biotech. 14:253-257.

Year 2001


Lyra, C., S. Suomalainen, M. Gugger, C. Vezie, P. Sundman, L. Paulin and K. Sivonen. 2001. Molecular characterization of planktic cyanobacteria of Anabaena, Aphanizomenon, Microcystis and Planktothrix genera. Int. J. System. Evol. Microbiol. 51: 513-526.

Lahti, K., J. Rapala, A.-L. Kivimäki, J. Kukkonen, M. Niemelä and K. Sivonen. 2001. Occurrence of microcystins in raw water sources and treated drinking water of Finnish waterworks. Water Science and Technology 43:225-228.

Laamanen, M. J., M. F. Gugger, J. M. Lehtimäki, K. Haukka and K. Sivonen. 2001. Diversity of toxic and non-toxic Nodularia isolates (cyanobacteria) in filaments from the Baltic Sea. Appl. Environ. Microbiol. 67(10):4638-4647.

Repka, S., J. Mentonen, J. Vaitomaa, L. Saari and K. Sivonen. 2001. Effects of nutrients on growth and nodularin production of Nodularia strain GB8b. Microbial Ecology 42(4):606-613.
Mikhailov, A., A.-S. Härmälä-Braskén, E. Polosukhina, A. Hanski, M. Wahlsten, K. Sivonen and J. E. Eriksson. 2001. Production and specificity of monoclonal antibodies against nodularin conjugated through N-methyldehydrobutyrine. Toxicon 39:1453-1459.

Year 2000


Rouhiainen, L., L. Paulin, S. Suomalainen, H. Hyytiäinen, W. Buikema, R. Haselkorn and K. Sivonen. 2000. Genes encoding synthetases of cyclic depsipeptides, anabaenopeptilides, in Anabaena strain 90. Molecular Microbiol. 37(1):156-167.

Lehtimäki, J., C. Lyra, S. Suomalainen, P. Sundman, L. Rouhiainen, L. Paulin, M. Salkinoja-Salonen and K. Sivonen. 2000. Characterization of Nodularia strains, cyanobacteria from brackish waters, by genotypic and phenotypic methods. Int. J. System. Evol. Microbiol. 50:1043-1053.

Fujii, K., K. Sivonen, E. Naganawa and K.-I. Harada. 2000. Non-toxic peptides from toxic cyanobacteria, Oscillatoria agardhii. Tetrahedron 56:725-733.

Fujii, K., T. Mayumi, K. Noguchi, T. Kashiwagi, S. Akashi, K. Sivonen, K. Hirayama and K.-I. Harada. 2000. Mass spectrometric studies of peptides from cyanobacteria under FAB MS/MS conditions. J. Mass Spectrom. Soc. Jpn. 48(1):56-64.

Engström, J., M. Koski, M. Viitasalo, M. Reinikainen, S. Repka and K. Sivonen. 2000. Feeding interactions of the copepods Eurytemora affinis and Acartia bifilosa with the cyanobacteria Nodularia sp. J. Plankton Res. 22(7):1403-1409.

Lyra, C., T. Halme, A.-M. Torsti, T. Tenkanen and K. Sivonen. 2000. Site-specific restriction endonucleases in cyanobacteria. J Appl. Microbiol. 89(6):979-991.

Töröknè, A. K., E. László, I. Chorus, K. Sivonen and F. A. Barbosa. 2000. Cyanobacterial toxins detected by Thamnotoxkit (a double blind experiment). Environ. Toxicol. 15(5):549-553.

Year 1999

Yuan, M., M. Namikoshi, A. Otsuki, K. L. Rinehart, K. Sivonen and M. F. Watanabe. 1999. Low–energy collisionally activated decomposition and structural characterization of cyclic heptapeptide microcystins by electrospray ionization mass spectrometry. J. Mass Spectrom. 34:33-43.

Sirén, H., M. Jussila, H. Liu, S. Peltoniemi, K. Sivonen and M.-L. Riekkola. 1999. Separation, purity testing and identification of cyanobacterial hepatotoxins with capillary electrophoresis and electrospray mass spectrometry. J. Chromatogr. A 839:203-215.

Neilan, B. A., E. Dittmann, L. Rouhiainen, R. A. Bass, V. Schaub, K. Sivonen and T. Börner. 1999. Nonribosomal peptide synthesis and toxigenicity of cyanobacteria. J. Bact. 181:4089-4097.

Fujii, K., K. Sivonen, T. Kashiwagi, K. Hirayama and K.-I. Harada, 1999. Nostophycin, a novel cyclic peptide from the toxic cyanobacterium, Nostoc sp. 152. J. Org. Chemistry 64:5777-5782.

Year 1998

Rapala, J. and K. Sivonen. 1998. Assessment of environmental conditions that favour hepatotoxic and neurotoxic Anabaena spp. strains cultured under light-limitation at different temperatures. Microbial Ecology 36:181-192.

Namikoshi, M., M. Yuan, K. Sivonen, W. W. Carmichael, K. L. Rinehart, L. Rouhiainen, F. Sun, S. Brittain, and A. Otsuki. 1998. Seven new microcystins possessing two L-Glu units, isolated from Anabaena sp. strain 186. Chem. Res. Toxicol. 11:143-149.

Vezie, C., L. Brient, K. Sivonen, G. Betru, J.-C- Lefeuvre and M. Salkinoja-Salonen. 1998. Variation of microcystin content of cyanobacterial blooms and isolated strains in Lake Grand-Lieu (France). Microbial Ecology 35:126-135.

Andersson, M. A., R. Mikkola, R. M. Kroppenstedt, F. A. Rainey, J. Peltola, J. Helin, K. Sivonen, and M. S. Salkinoja-Salonen. 1998. Mitochondrial toxin produced by Streptomyces griseus strains isolated from indoor environment is valinomycin. Appl. Environ. Microbiol. 64(12):4767-4773.

Yuan, M., M. Namikoshi, A. Otsuki and K. Sivonen. 1998. Effect of amino acid side-chain on fragmentation of cyclic peptide ions: differences of ESIMS/CID/mass spectra of toxic heptapeptide microcystins containing ADMAdda instead of Adda. Eur. Mass Spectrom. 4:287-297.

Year 1997

Lahti K., J. Rapala, M. Färdig, M. Niemelä and K. Sivonen. 1997. Persistence of cyanobacterial hepatotoxin, microcystin-LR, in particulate material and dissolved in lake water. Water Research 31(5):1005-1012.

Vezie, C., L. Brient, K. Sivonen, G. Betru, J.-C- Lefeuvre and M. Salkinoja-Salonen. 1997. Occurrence of microcystins containing cyanobacterial blooms in freshwaters of Brittany (France). Arch Hydrobiol. 139:401-413.

Lehtimäki. J., P. Moisander, K. Sivonen and K. Kononen. 1997. Growth, nitrogen fixation and nodularin production by two Baltic Sea cyanobacteria. Appl. Environ. Microbiol. 63(5):1647-1656.
Rapala, J., K. Sivonen, C. Lyra and S. I. Niemelä. 1997. Variation of microcystins, cyanobacterial hepatotoxins, in Anabaena spp. as a function of growth stimuli. Appl. Environ. Microbiol. 64(6):2206-2212.

Lyra, C., J. Hantula, E. Vainio, J. Rapala, L. Rouhiainen and K. Sivonen. 1997. Characterization of cyanobacteria by SDS-PAGE of whole cell proteins and PCR/RFLP of the 16S rRNA gene. Archives of Microbiology 168:176-184.

Fujii, K., K. Sivonen, K. Adachi, K. Noguchi, H. Sano, K. Hirayama, M. Suzuki and K.-I. Harada. 1997. Comparative study of toxic and non-toxic cyanobacterial products: novel peptides from toxic Nodularia spumigena AV1. Tetrahedron Letters 38:5525-5528.

Fujii, K., K. Sivonen, K. Adachi, K. Noguchi, Y. Shimizu, H. Sano, K. Hirayama, M. Suzuki and K.-I. Harada. 1997. Comparative study of toxic and non-toxic cyanobacterial products: a novel glycoside, suomilide from non-toxic Nodularia spumigena HKVV. Tetrahedron Letters 38:5529-5532.

Pelander, A., K. Sivonen, I. Ojanperä, and H. Vuorela. 1997. Retardation behavior of cyanobacterial hepatotoxins in the irregular part of the ‘PRISMA’model for thinlayer chromatography. Journal of Planar Chromatography 10:434-440.

Year 1996

Sivonen K. 1996. Cyanobacterial toxins and toxin production - Review. Phycologia 35(6):12-24.

Annila, A., J. Lehtimäki, K. Mattila, J. E. Eriksson, K. Sivonen, T. T. Rantala and T. Drakenberg. 1996. Solution structure of nodularin an inhibitor of serine/threonine specific
protein phosphatases. J. Biol. Chem. 271(28):16695-16702.

Pelander A., I. Ojanperä, K Sivonen, K. Himberg, M. Waris, K. Niinivaara and E. Vuori. 1996. Screening for cyanobacterial toxins in bloom and strain samples by thin layer chromatography. Water Research 30(6):1464-1470.

Vezie, C., F. Benoufella, K. Sivonen, G. Betru and A. Laplanche. 1996. Detection of toxicity of cyanobacterial strains using Artemia salina and Microtox® assays. Phycologia 35(6):198-202.

Moisander, P., J. Lehtimäki, K. Sivonen and K. Kononen. 1996. Comparison of 15N2 and asetylene reduction methods for the measurement of nitrogen fixation by Baltic Sea cyanobacteria. Phycologia 35(6):140-146.

Vasconcelos, V. M., K. Sivonen, W. R. Evans, W. W. Carmichael and M. Namikoshi. 1996. Microcystin (heptapeptide hepatotoxins) diversity in cyanobacterial blooms collected in Portuguese fresh waters. Water Research 30:2377-2384.

Vezie, C., Sivonen, K., Brient, L., Bertru, G. and Lefeuvre, J. C. 1996. Development of toxic cyanobacteria in western France - detection of toxicity with Artemia salina test. Annales de Limnologie (French) 32(2):123-128.

Year 1995

Rouhiainen, L., K. Sivonen, W. Buikema and R. Haselkorn. 1995. Characterization of toxin-producing cyanobacteria by using an oligonucletide probe containing a tandemly repeated heptamer. J. Bact. 177(20):6021-6026.

Lahti, K., J. Ahtiainen, J. Rapala, K. Sivonen and S. I. Niemelä. 1995. Assessment of rapid bioassays for detecting cyanobacterial toxicity. Letters in Applied Microbiol. 21:109-114.

Vasconcelos, V. M., K. Sivonen, W. R. Evans, W. W. Carmichael and M. Namikoshi. 1995. Isolation and characterization of microcystins (heptapeptide hepatotoxins) from Portuguese strains of Microcystis aeruginosa Kutz ememn Elkin. Arch. Hydrobiol. 134:295-305.

Hemscheidt, T., J. Rapala, K. Sivonen and O. M. Skulberg. 1995. Biosynthesis of anatoxin-a in Anabaena flos-aquae and homoanatoxin-a in Oscillatoria formosa. Am. Chem. Soc., Chemical Communications, 1361-1362.

Year 1994

Luukkainen, R., M. Namikoshi, K. Sivonen, K. L. Rinehart and S. I. Niemelä. 1994. Isolation and identification of 12 microcystins from four strains and two bloom samples of Microcystis spp.: structure of a new hepatotoxin. Toxicon 32:133-139.

Lehtimäki, J., K. Sivonen, R. Luukkainen and S. I. Niemelä. 1994. The effects of incubation time, temperature, light, salinity and phosphorus on growth and hepatotoxin production by Nodularia strains. Arch. Hydrobiol. 130:269-282.

Rapala, J., K. Lahti, K. Sivonen and S. I. Niemelä. 1994. Biodegradability and adsorption on lake sediments of cyanobacterial hepatotoxins and anatoxin-a. Letters in Appl. Microbiol. 19:423-428.

Year 1993

Luukkainen, R., K. Sivonen, M. Namikoshi, M. Färdig, K. L. Rinehart and S. I. Niemelä. 1993. Isolation and identification of eight microcystins from 13 Oscillatoria agardhii strains: structure of a new microcystin. Appl. Environ. Microbiol. 59:2204-2209.

Rapala, J., K. Sivonen, R. Luukkainen and S. I. Niemelä. 1993. Anatoxin-a concentration in Anabaena and Aphanizomenon at different environmental conditions and comparison of growth by toxic and non-toxic Anabaena strains - a laboratory study. J. Appl. Phycology 5:581-591.

Kiviranta, J., A. Abdel-Hameed, K. Sivonen, S. I. Niemelä and G. Carlberg. 1993. Toxicity of cyanobacteria to mosquito larvae - screening of active compounds. Environ. Toxicol. Water Quality 8:63-71.

Abdel-Hameed, A., J. Kiviranta, K. Sivonen, S. Niemelä and G. Carlberg. 1993. Algae in mosquito breeding sites and the effectiveness of the mosquito larvicide Bacillus turingiensis H-14. World J. Microbiol. Biotechnol. 9:156-159.

Harada, K.-I., H. Nagai, Y. Kimura, M. Suzuki, H.-D. Park, M. F. Watanabe, R. Luukkainen, K. Sivonen and W. W. Carmichael. 1993. Liquid chromatography/mass spectrometric detection of anatoxin-a, a neurotoxin from cyanobacteria. Tetrahedron 49:9251-9260.

Year 1992

Sivonen, K., M. Namikoshi, W. R. Evans, W. W. Carmichael, F. Sun, L. Rouhiainen, R. Luukkainen and K. L. Rinehart. 1992. Isolation and characterization of a variety of microcystins from seven strains of the cyanobacterial genus Anabaena. Appl. Environ. Microbiol. 58(8):2495-2500.

Sivonen, K., M. Namikoshi, W. R. Evans, M. Färdig, W. W. Carmichael and K. L. Rinehart. 1992. Three new microcystins, cyclic heptapeptide hepatotoxins, from Nostoc sp. strain 152. Chem. Res. Toxicol. 5(4):464-469.

Sivonen, K., M. Namikoshi, W. R. Evans, B. V. Gromov, W. W. Carmichael and K. L. Rinehart. 1992. Isolation and structures of five microcystins from a Russian Microcystis aeruginosa strain CALU 972. Toxicon 30(11):1481-1485.

Sivonen, K., O. M. Skulberg, M. Namikoshi, W. R. Evans, W. W. Carmichael and K. L. Rinehart. 1992. Two methyl ester derivates of microcystins, cyclic heptapeptide hepatotoxins, isolated from Anabaena flos-aquae strain CYA 83/1. Toxicon 30(11):1465-1471.

Ekman-Ekebom, M., M. Kauppi, K. Sivonen, M. Niemi and L. Lepistö. 1992. Toxic cyanobacteria in some Finnish lakes. Environ. Toxicol. Water Quality 7:210-213.

Kiviranta, J., M. Namikoshi, K. Sivonen, W. R. Evans, W. W. Carmichael and K. L. Rinehart. 1992. Structure determination and toxicity of a new microcystin from Microcystis aeruginosa strain 205. Toxicon 30(9):1093-1098.

Namikoshi, M., K. Sivonen, W. R. Evans, W. W. Carmichael, L. Rouhiainen, R. Luukkainen and K. L. Rinehart. 1992. Structures of three new homotyrosine containing microcystins and a new homophenylalanine variant from Anabaena sp. strain 66. Chem. Res. Toxicol. 5:661-666.

Namikoshi, M., K. Sivonen, W. R. Evans, W. W. Carmichael, F. Sun, L. Rouhiainen, R. Luukkainen and K. L. Rinehart. 1992. Two new L-serine variants of microcystins-LR and -RR from Anabaena sp. strains 202A1 and 202A2. Toxicon 30(11):1457-1464.

Namikoshi, M., K. Sivonen, W. R. Evans, F. Sun, W. W. Carmichael and K. L. Rinehart. 1992. Isolation and structures of microcystins from a cyanobacterial water bloom (Finland). Toxicon 30(11):1473-1479.

Year 1991

Kiviranta, J., K. Sivonen, R. Luukkainen, K. Lahti and S. I. Niemelä. 1991. Production and biodegradation of cyanobacterial toxins - a laboratory study. Arch. Hydrobiol. 121:281-294.
Kiviranta, J., K. Sivonen, S. I. Niemelä and K. Huovinen. 1991. Detection of toxicity of cyanobacteria by Artemia salina bioassay. Environ. Toxicol. Water Quality 6:423-436.

Year 1990

Sivonen, K. 1990. Effects of light, temperature, nitrate, ortophosphate, and bacteria on growth of and hepatotoxin production by Oscillatoria agardhii strains. Appl. Environ. Microbiol. 56(9):2658-2666.

Sivonen, K., W. W. Carmichael, M. Namikoshi, K. L. Rinehart, A. M. Dahlem and S. I. Niemelä. 1990. Isolation and characterization of hepatotoxic microcystin homologs from the filamentous freshwater cyanobacterium Nostoc sp. strain 152. Appl. Environ. Microbiol. 56(9):2650-2657.
Sivonen, K., S. I. Niemelä, R. M. Niemi, L. Lepistö, T. H. Luoma and L. A. Räsänen. 1990. Toxic cyanobacteria (blue-green algae) in Finnish fresh and coastal waters. Hydrobiologia 190:267-275.

Martin, C., K. Sivonen, U. Matern, R. Dierstein and J. Weckesser. 1990. Rapid purification of the peptide toxins microcystin-LR and nodularin. FEMS Microbiol. Lett. 68:1-6.

Meriluoto, J. A. O., J. E. Eriksson, K.-I. Harada, A. M. Dahlem, K. Sivonen and W. W. Carmichael. 1990. Internal surface reversed-phase separation of the cyanobacterial peptide toxins microcystin-LA, -LR, -YR, - RR and nodularin. J. Chromatogr. 509:390-395.

Namikoshi, M., K. L. Rinehart, R. Sakai, K. Sivonen and W. W. Carmichael. 1990. Structures of three new cyclic heptapeptide hepatotoxins produced by the cyanobacterium (blue-green alga) Nostoc. sp. strain 152. J. Org. Chem. 55:6135-6139.

Year 1989 and before

Sivonen, K., K. Himberg, R. Luukkainen, S. I. Niemelä G. Poon and G. Codd. 1989. Preliminary characterization of neurotoxic blooms and strains from Finland. Toxicity Assessment 4:339-352.

Sivonen, K., K. Kononen, W. W. Carmichael, A. M. Dahlem, K. Rinehart, J. Kiviranta and S. I. Niemelä. 1989. Occurrence of the hepatotoxic cyanobacterium Nodularia spumigena in the Baltic Sea and the structure of the toxin. Appl. Environ. Microbiol. 55(8):1990-1995.

Sivonen, K., K. Kononen, A.-L. Esala and S. I. Niemelä. 1989. Toxicity and isolation of the cyanobacterium Nodularia spumigena from the southern Baltic Sea in 1986. Hydrobiologia 185:3-8.

Himberg, K., A.-M. Keijola, L. Hiisvirta, H. Pyysalo and K. Sivonen. 1989. The effect of water treatment processes on the removal of hepatotoxins from Microcystis and Oscillatoria cyanobacteria: a laboratory study. Water Research 23:979-984.

Keijola, A.-M., K. Himberg, A.-L. Esala, K. Sivonen and L. Hiisvirta. 1988. Removal of cyanobacterial toxins in water treatment processes - laboratory and pilot scale experiments. Toxicity Assessment 3:643-656.

Vaara, T., Sivonen, K. and S. Kurkela. 1984. Mixotrophic growth of Nostoc 268. Advances in Photosynthesis Research 2:809-812.

Sivonen, K. 1982. Factors influencing odour production by Actinomycetes. Hydrobiologia 86:401-405.

Sivonen, K. and I. M. Szabo. 1981. Is the colour of the mature aerial mycelium (spore mass) of Streptomycetes a diagnostic key-character of decisive taxonomic importance? Acta Microbiol. Acad. Sci. Hung. 28:401-405.


2. Papers in scientific books with referee-system (non-Finnish) – total of 22:

Rantala-Ylinen, A., H. Sipari and K. Sivonen. 2011. Molecular methods - chip assay and quantitative real-time PCR - in detecting hepatotoxic cyanobacteria. Book Chapter in Microbial Toxins: Methods and Protocols. Methods in Molecular Biology 739, edited by Otto Holst. pp. 73-86. Springer Protocols. Humana Press Springer, New York, USA

Sivonen, K. 2009. Cyanobacterial toxins. In: "Encyclopedia of Microbiology", 3rd Edition, edited by Moselio Schaechter, pp. 290-307. Elsevier, Oxford, U. K.

Sivonen, K. and T. Börner. 2008. Bioactive compounds produced by cyanobacteria. Book Chapter In: "The cyanobacteria: Molecular Biology, Genomics and Evolution", Herraro, A. & E. Flores (Eds.). p. 159-197. Caister Academic Press, Norfolk, U. K.

Sivonen, K. 2008. Emerging high throughput analyses of cyanobacterial toxins and toxic cyanobacteria. Chapter 24. In: "Proceedings of the Interagency, International Symposium on Cyanobacterial Harmful Algal Blooms", H. K. Hudnell (ed.). Advances in Experimental Medicine & Biology vol. 619, p. 523-542. Springer, New York. (Pdf of the whole book available in http://www.epa.gov/cyano_habs_symposium/monograph.html)

De la Cruz, A. A., P. Rublee, J. M. Hungerford, P. V. Zimba, S. W. Wilhelm, J.A.O. Meriluoto, K. Echols, M. T. Mayer, G. Stelma, R. Mandeville. L. Lawton, K. Sivonen and A. Furey. 2008 Analytical Methods Workgroup Report. Chapter 20. In: "Proceedings of the Interagency, International Symposium on Cyanobacterial Harmful Algal Blooms", H. K. Hudnell (ed.). Advances in Experimental Medicine & Biology vol. 619, p. 469-481. Springer, New York, USA.
Heikkinen, E., K, Haukka, K. Björklöf, K. Sivonen and T. Kairesalo. 2005. Structural and functional responses of bacteria living in rhizosphere and macrophyte-free sediment to humus addition into water column. Verh. Internat. Verien. Limnol. 29: 857-860.

Rajaniemi, P., J. Komárek, R. Willame, P. Hrouzek, K. Kaštovská, L. Hoffmann and K. Sivonen. 2005. Taxonomic consequences from the combined molecular and phenotypic evaluation of selected Anabaena and Aphanizomenon strains. Algological Studies 117:371-391.

Sivonen, K. 2004. Toxic cyanobacteria research. Chapter 11, In: Inland and coastal waters of Finland. P. Eloranta (Ed.). p. 123-131. Palmenia Publishing, Saarijärvi, Finland.
Sivonen, K. 2000. Chapter 26, Freshwater cyanobacterial neurotoxins: ecobiology, chemistry and detection. In: Seafood and Freshwater Toxins. L. M. Botana (Ed). p. 567-582. Marcel Dekker, Inc., New York, USA.

Sivonen, K. 2000. Toxic cyanobacteria. In: Hydrological and Limnological Aspects of Lake Monitoring. P. Heinonen, G. Ziglio & A. van der Beken (Eds). p. 81-96. John Wiley & Sons Ltd, Chichester, U.K.

Sivonen, K. and G. Jones. 1999. Chapter 3, Cyanobacterial toxins. In: Toxic Cyanobacteria in Water: a Guide to Public Health Significance, Monitoring and Management. I. Chorus & J. Bertram (Eds.). p. 41-111. The World Health Organization. ISBN 0-419-23930-8. E & FN Spon, London, U. K.

Sivonen, K. 1998. Toxin produced by cyanobacteria. In: Mycotoxins and Phycotoxins – Developments in Chemistry, Toxicology and Food Safety. M. Miraglia, H. van Egmond, C. Brera & J. Gilbert (Eds.). p. 547-568. Printed in the U.S.A.

Lahti, K., M. R. Niemi, J. Rapala and K. Sivonen. 1998. Biodegradation of cyanobacterial hepatotoxins - characterization of toxin degrading bacteria. In: B. Reguera, J. Blanco, M. L. Fernandez & T. Wyatt (Eds.). Harmful Algae. p. 363-365. Xunta de Galicia and Intergovernmental Oceanographic Commission of UNESCO 1998. Santiago de Compostela, Spain.

Lahti, K., J. Vaitomaa, A.-L. Kivimäki and K. Sivonen. 1998. Fate of cyanobacterial hepatotoxins in artificial recharge of groundwater and in bank filtration. In: Peters et al., (Eds.). Artifical recharge of groundwater. p. 211-216. Balkema, Rotterdam, ISBN 90 5809 0175.

Jussila, M., H. Sirén, K. Sivonen and M.-L. Riekkola. 1998. Electrophoretic separation of microcystins and reliable identification with electrospray – mass spectrometry. In: Proceedings of the 20th International Symposium on Capillary Chromatography. P. Sandra & A. J. Rackstraw (Eds). p. 1-10. NAXOS, Schriesheim, Germany.

Fujii, K., K.-I. Harada, M. Suzuki, F. Kondo, Y. Ikai, H. Oka, W.W. Carmichael and K. Sivonen. 1996. Occurrence of novel cyclic peptides together with microcystins from toxic cyanobacteria, Anabaena species. In: T. Yasumoto, Y. Oshima & Y. Fukuyo (Eds). Harmful and Toxic Algal Blooms, p. 559-562. Intergovernmental Oceanographic Comission of UNESCO, Paris.
Sirén, H., M.-L. Riekkola, H. Liu and K. Sivonen. 1996. Separation of microcystins by capillary electrophoresis. Eighteenth International Symposium on Capillary Chromatography. p. 2095-2099. Kortrijk:Hüthig.

Sivonen, K., M. Namikoshi, R. Luukkainen, M. Färdig, L. Rouhiainen, W. R. Evans, W. W. Carmichael, K. L. Rinehart and S. I. Niemelä. 1995. Variation of cyanobacterial hepatotoxins in Finland. In: M. Munawar & M. Luotola (eds.). The Contaminats in the Nordic Ecosystem: Dynamics, Processes & Fate. Ecovision World Monograph Series. p. 163-169. SPB Academic Publishing, Amsterdam, The Netherlands.

Sivonen, K., M. Namikoshi, R. Luukkainen, M. Färdig, L. Rouhiainen, W. R. Evans, W. W. Carmichael, K. L. Rinehart and S. I. Niemelä. 1994. Variation of cyanobacterial hepatotoxins in Finland. In: G.A: Codd, T.M. Jefferies, C.W. Keevil & E. Potter (Eds.). Detection Methods for Cyanobacterial Toxins. p. 152-154. The Royal Society of Chemistry, Cambridge, U. K.

Kononen, K., K. Sivonen and J. Lehtimäki. 1993. Toxicity of the phytoplankton blooms in the Gulf of Finland and Gulf of Bothnia, Baltic Sea. In: T.J. Smayda & Y. Shimizu (Eds). Toxic Phytoplankton Blooms in the Sea. p. 269-273. Elsevier, Amsterdam.

Rinehart, K. L., M. Namikoshi, A. G. Thompson, L. S. Shield, G. Gäde, C. J. P. Grimmelikhuijzen, H.-P. Nothacker, W. W. Carmichael, K. Sivonen, C. C. Doughty and C. E. Grimshaw. 1991. Tandem mass spectrometry (FABMS/MS) studies of peptides and proteins. In: Atta-ur-Rahman (Ed). Studies in Natural Products Chemistry. pp. 487-507. Elsevier, Amsterdam.

Kiviranta, J., K. Sivonen, K. Lahti, R. Luukkainen and S. I. Niemelä. 1989. Accumulation and decomposition of phycotoxins during growth and decay of Oscillatoria agardhii. 37th Annual Congress on Medical Plant Research. p. 87-88. Georg Thieme Verlag, Stuttgart, Germany.



Patents and patent applications:

Sivonen, K., A. Rantala, L. Rouhiainen, D. Fewer, G. DeBellis, B. Castiglioni, E. Rizzi & A. Frosini. Menetelmä toksisten syanobakteerien määrittämiseksi (Method for detecting toxic cyanobacteria). FI20030770. Finnish patent filed in May 2003.

Sivonen, K., A. Rantala, L. Rouhiainen, D. Fewer, P. Rajaniemi, A. Wilmotte, V. Boutte, S. Grubisic P. Balthasart, G. DeBellis, E. Rizzi, A. Frozini, B. Castiglioni, S. Ventura, M. Mugnai. Menetelmä toksisten ja ei toksisten syanobakteerien määrittämiseksi (Method for detecting toxic and non-toxic cyanobacteria). FI 20030771. Finnish patent filed in May 2003.

Sivonen, K., A. Rantala, L. Rouhiainen, D. Fewer, P. Rajaniemi, A. Wilmotte, V. Boutte, S. Grubisic P. Balthasart, G. DeBellis, E. Rizzi, A. Frozini, B. Castiglioni, S. Ventura, M. Mugnai. Method for detecting toxic and non-toxic cyanobacteria. USPatent filed in May 2004 (continuation of the Finnish patent FI 20030771). United States Patent 20070059699, publication date 15th March 2007.

Sivonen, K., A. Rantala, L. Rouhiainen, D. Fewer, P. Rajaniemi, A. Wilmotte, V. Boutte, S. Grubisic P. Balthasart, G. DeBellis, E. Rizzi, A. Frozini, B. Castiglioni, S. Ventura, M. Mugnai. Method for detecting toxic and non-toxic cyanobacteria. Patent filed in Europe in May 2004 (continuation of the Finnish patent FI 20030771). European patent EP1629114 (A2) with publication date 2006-03-01.

Sivonen, K., J. Jokela, M. Wahlsten, P. Permi, S. O. Døskeland and L. Herfindal. “Bioaktiivinen syklinen peptidi” (Bioactive cyclic peptide). FI 20060526. Finnish pre-patent filed in May 2006. Date of International patent publication 06.12.2007, PTC/FI2007/050312.


Ph D theses completed in the group
Niina Leikoski, 2013. Cyanobacteins – Ribosomally Synthetized and Post-Traslationally Modified peptides produced by Cyanobaceteria. Dissertationes Biocentri Viikki Universitatis Helsingiensis 15/2013.  Defence August 16, 2013. (Supervised by Kaarina Sivonen, David Fewer & Jouni Jokela). Thesis approved with distinction.

Hanna Sinkko, 2013. Sediment Bacterial Communities in Nutrient Cycling and in the History of the Baltic Sea. Dissertationes Biocentri Viikki Universitatis Helsingiensis 16/2013.  Defence August 22, 2013. (Supervised by Christina Lyra & Kaarina Sivonen)

Katri Berg 2009. Heterotrophic bacteria associated wuith cyanobacteria in recreational and drinking water. Dissertationes bioscientiarum molecularium Universitatis Helsingiensis in Viikki. 46/2008. (Supervisors Jarkko Rapala, Christian Lyra and  K. Sivonen)

Katrianna Halinen 2008. Genetic diversity and microcystin production by Anabaena in the Gulf of Finland, Baltic Sea. Dissertationes bioscientiarum molecularium Universitatis Helsingiensis in Viikki. 46/2008. (Supervisor K. Sivonen)

Anne Rantala 2007. Evolution and detection of cyanobacterial hepatotoxin synthetase genes. Dissertationes bioscientiarum molecularium Universitatis Helsingiensis in Viikki. 29/2007. (supervisor K. Sivonen). Thesis approved with distinction.

Pirjo Wacklin 2006. Biodiversity and phylogeny of planktic cyanobacteria in temperate freshwaters Dissertationes Biocentri Viikki Universitatis Helsingiensis 12/2006 (supervisor K. Sivonen).

Jaana Vaitomaa 2006. Effects of environmental factors on growth and microcystin production of freshwater cyanobacterial genera Microcystis and Anabaena. Dissertationes Biocentri Viikki Universitatis Helsingiensis 15/2006. (supervisior K. Sivonen).

Spyros A. Gkelis 2006. Characterization of planktonic cyanobacteria and their peptide toxins. Doctoral Dissertation. School of Biology, Department, Faculty of Sciences, Aristotele University of Tessaloniki, Scientific Annals of School of Biology. (supervisors T. Lanaras, M. Moustaka-Gouni  and K. Sivonen)

Ilona Oksanen 2004: Specificity in cyanobacteria lichen symbiosis and bioactive metabolites (ethylene and microcystins) Dissertationes Biocentri Viikki Universitatis Helsingiensis 23/2004  (supervisors KS & J. Rikkinen). Approved with distiction.

Leo Rouhiainen 2004: Characterization of Anabaena cyanobacteria: repeated sequences and genes involved in biosynthesis of microcystins and anabaenopeptilides. Biocentri Viikki Universitatis Helsingiensis 30/2004. (supervisor KS). Approved with distiction.

Maria Laamanen 2002. Genetic and species diversity of planktonic cyanobacteria in the northern Baltic Sea. (supervisors Dr. K. Kononen & KS)

Christina Lyra 2002. Molecular characterization of the cyanobacetrial genera Anabaena, Aphanizomenon, Microcystis and Planktothrix. Dissertationes Biocentri Viikki Universitatis Helsingiensis 10/2002  (supervisor KS).

Muriel Gugger  2001. Etudes taxinomique et phylogenetique des cyanobacteries toxiques d’eau douce par des approaches biochimique et moleculaire. University Paris7. (supervisors prof. A. Coute & KS).

Jaana Lehtimäki, 2000. Characterisation of cyanobacterial strains originating from the Baltic Sea with emphasis on Nodularia and its toxin nodularin. Dissertationes Biocentri Viikki Universitatis Helsingiensis 15/2000 (supervisor KS). Approved with distiction.

Jarkko Rapala, 1998. Toxin production by freshwater cyanobacteria: effects of environmental factors. Dissertationes Biocentri Viikki Universitatis 9/1998.