REGULATION OF TOOTH AND BONE DEVELOPMENT
Phone: +358-9-708 59401
The molecular mechanisms
regulating embryonic development have been conserved to a great extent
during evolution. Of central importance is intercellular communication
mediated by complex signaling networks. We use the mammalian tooth as a
model to analyse the signaling pathways in the inductive cell and tissue
interactions that govern morphogenesis and cell differentiation. In addition,
we have started to analyse signaling systems regulating intramembranous
The specific aims of the project are: 1) to analyse the roles of individual components of the signaling pathways, including signals, receptors and transcription factors, especially in the families of hedgehog, BMP, wnt, and FGF signals, 2) to analyse the function of the enamel knot, 3) to examine the role of apoptosis, cell division and cell migration in tooth and bone morphogenesis, 4) to search for new developmental regulatory genes, 5) to clarify the functions of the recently cloned Tabby- and Cbfa-1 genes in tooth development, and 6) to identify genes controlling the developmental basis of tooth shape evolution
Post-docs: Jukka Jernvall, Risto Jaatinen, Marja Mikkola, Janna Waltimo, David Rice, Ph.D. students: Soile Keränen, Tuija Mustonen, Pekka Nieminen, Leila Pakarinen, Johanna Pispa, Johanna Laurikkala, Mark Tummers, Thomas Åberg. Technicians: Kaija Kettunen, Merja Mäkinen, Riikka Santalahti
S., Karavanova, I., Jowett, A., Thesleff, I. Identification of BMP-4 as
a signal mediating
A., Åberg, T., Jernvall, J., Keränen, S., Thesleff, I. The enamel
knot as a signaling
A., Åberg, T., Thesleff, I. Apoptosis in the developing tooth: Association
Åberg, T., Wozney, J., Thesleff, I. Expression patterns of BMPs in the developing mouse tooth suggests roles in morphogenesis and cell differentiation. Dev. Dyn. 210: 407-416, 1997.
Jernvall, J., Åberg, T., Kettunen,P., Keränen,S., Thesleff, I. The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Development 125: 161-169, 1998.
Kim, HJ, Rice, DPC, Kettunen, PJ, Thesleff, I. FGF, BMP, and Shh mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development 125: 1241-1251, 1998.
Harada, H, Kettunen, P, Jung, HS, Mustonen, T, Wang, YA, Thesleff, I. Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. J Cell Biol: 147(1): 105-120, 1999.
Gene expression in tooth (WWW database): http://bite-it.helsinki.fi. Developmental Biology Programme of the University of Helsinki, 1996.
Academy of Finland, University of Helsinki (center of excellence grant), Human Frontier Science Program, Sigrid Jusélius Foundation, European Orthodontic Society, Ministry of Education of Japan, Institute of Biotechnology, Biocentrum Helsinki.
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