Main publications
Mart Saarma: List of Publications 2008-2011 (Top 5 publications marked #) Articles in international refereed scientific journals Andressoo, J.-O. and Saarma, M. (2008) Signalling mechanisms underlying development and maintenance of dopamine neurons. Curr Opin Neurobiol., 18, 297–306. (IF=8.9, NC=11) Immonen, T., Alakuijala, A., Hytönen, M., Sainio, K., Poteryaev, D., Saarma, M., Pasternack, M., and Sariola, H. (2008) A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus. Exp. Neurol., 210 (2), 793-796. (IF=4.1, NC=3) Katritzky, A. R., Dobchev, D. A., Stoyanova-Slavova, I. B., Kuanar, M., Bespalov, M. M., Karelson, M. and Saarma, M. (2008) Novel computational models for predicting dopamine interactions. Exp Neurol, 211 (1), 150-171. (IF=4.1, NC=1) Lindholm, P., Peränen, J., Andressoo, J.O., Kalkkinen, N., Kokaia, Z., Lindvall, O., Timmusk, T. and Saarma M. (2008) MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain. Mol Cell Neurosci., 39(3), 356-371. (IF=3.9, NC=18) Mijatovic, J., Patrikainen, O., Yavich, L., Airavaara, M., Ahtee, L., Saarma, M. and Piepponen, T.P. (2008) Characterization of the striatal dopaminergic neurotrans-mission in MEN2B mice with elevated cerebral tissue dopamine. J Neurochem, 105(5), 1716-1725. (IF=4.2, NC=2) Parkash, V., Leppänen, V-M., Virtanen, H., Jurvansuu, J. M., Bespalov, M. M., Sidorova, Y. A., Runeberg-Roos, P., Saarma, M. and Goldman, A. (2008) The Structure of the glial cell line-derived neurotrophic factor-coreceptor complex. Insights into RET signalling and heparin binding. J Biol Chem, 283, (50), 35164-35172. (IF=6.9, NC=18) Paveliev, M., Hienola, A., Jokitalo, E., Planken, A., Bespalov, M.M., Rauvala, H. and Saarma, M (2008) Sensory neurons from N-syndecan-deficient mice are defective in survival. NeuroReport, 19(14), 1397-400. (IF=2, NC=3) Shulga, A., Thomas-Crusells, J., Sigl, T., Blaesse, A., Mestres, P., Meyer, M. Yan, Q., Kaila, K., Saarma, M, Rivera, C. and Giehl, K. (2008) Posttraumatic GABAA-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons. J Neurosci, 28(27), 6996-7005. (IF=8.2, NC=18) Tsang WY, Bossard C, Khanna H, Peränen J, Swaroop A, Malhotra V, Dynlacht BD (2008). CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. Dev Cell. 5(2):187-197. (IF=13.3, NC=36) Yu, L.-Y., Saarma, M. and Arumäe, U. (2008) Death receptors and caspases but not mitochondria are activated in the GDNF- or BDNF-deprived dopaminergic neurons. J. Neurosci., 28 (30), 7467-7475. (IF=8.2, NC=10) Airavaara M, Shen H, Kuo CC, Peränen J, Saarma M, Hoffer B, Wang Y. (2009) Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats. J Comp Neurol ;515 (1):116-124. (IF=3.7, NC=6) Laakkonen JP, Mäkelä AR, Kakkonen E, Turkki P, Kukkonen S, Peränen J, Ylä-Herttuala S, Airenne KJ, Oker-Blom C, Vihinen-Ranta M, Marjomäki V (2009). Clathrin-independent entry of baculovirus triggers uptake of E. coli in non-phagocytic human cells. PLoS One. 4(4):e5093. (IF=4.3, NC=12) Parkash, V., Lindholm, P., Peränen, J., Kalkkinen, N., Oksanen, E., Saarma, M., Leppänen, V-M. and Goldman, A. (2009) The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. Protein Eng.Des. Sel., 22(4):233-241. (IF=3.6, NC=12) #Palgi M, Lindström R, Peränen J, Piepponen TP, Saarma M, Heino TI. (2009) Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons. Proc. Natl. Acad. Sci. U S A., 106 (7): 2429-2434. (IF=9.4, NC=17). Discovery of the first neurotrophic factor in Drosophila and demonstrating that it maintains dopamine neurons and dopamine levels in the flies Piltonen M, Bespalov MM, Ervasti D, Matilainen T, Sidorova YA, Rauvala H, Saarma M, Männistö PT.(2009) Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons. Exp Neurol. 219(2): 499-506. (IF=4.1, NC=9) Saarma M., (2009). GFL Neurotrophic Factors: Physiology and Pharmacology. Encyclopedia of Neuroscience, volume 4, pp. 711-720. (L.R. Squire, Editor. Oxford: Academic Press. #Voutilainen, M.H., Bäck, S., Pörsti, E., Toppinen, L., Lindgren, L., Lindholm, P., Peränen, J., Saarma, M*. and Tuominen, R. K. (2009) Neurotrophic factor MANF is neurorestorative in rat model of Parkinson’s disease. J. Neurosci., 29(30):9651-9659.* Corresponding author. (IF=8.2, NC=29). First demonstration that MANF has effecst in vivo and has neuroprotective and neurorestorative effects in animal models of Parkinson’s disease. Airavaara M, Chiocco MJ, Howard DB, Zuchowski KL, Peränen J, Liu C, Fang S, Hoffer BJ, Wang Y, Harvey BK. (2010) Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury. Exp Neurol. 225(1):104-113. (IF=4.1, NC=2) Bryant DM, Datta A, Rodríguez-Fraticelli AE, Peränen J, Martín-Belmonte F, Mostov KE. (2010) A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol. 12(11):1035-1045. (IF=19.5, NC=24) Lindholm P, Saarma M.(2010) Dev Neurobiol. Novel CDNF/MANF family of neurotrophic factors, 70(5): 360-371. (IF=2.7, NC=6) #Lonka-Nevalaita L, Lume M, Leppänen S, Jokitalo E, Peränen J and Saarma M. (2010) Characterization of the intracellular localization, processing and secretion of two GDNF splice isoforms. J. Neurosci. , 30(34):11403-11413. (IF=8.2, NC=0) Elucidating the mechanism of GDNF secretion and demonstration that one GDNF isoform is secreted in the activity-dependent manner, whereas the other constitutively Hellman M, Peranen J, Saarma M, and Permi P. (2010) H-1, C-13 and N-15 resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor. Biomelecular NMR Assignments. 4 (2): 215-217. (IF=0.75, NC=1) Knödler A, Feng S, Zhang J, Zhang X, Das A, Peränen J, Guo W. (2010) Coordination of Rab8 and Rab11 in primary ciliogenesis. Proc Natl Acad Sci U S A. 107(14): 6346-6351. (IF=9.4, NC=29) Schollenberger L, Gronemeyer T, Huber CM, Lay D, Wiese S, Meyer HE, Warscheid B, Saffrich R, Peränen J, Gorgas K, Just WW.(2010) RhoA regulates peroxisome association to microtubules and the actin cytoskeleton. PLoS One. ;5(11):e13886. (IF=4.3, NC=1) Sidorova YA, Mätlik K, Paveliev M, Lindahl M, Piranen E, Milbrandt J, Arumäe U, Saarma M, Bespalov MM. (2010) Persephin signaling through GFRalpha1: the potential for the treatment of Parkinson's disease. Mol Cell Neurosci. 44 (3):223-232. (IF=3.9, NC=9) #Bespalov MM, Sidorova Y A, Tumova S, Ahonen-Bishopp A, Magalhães AC, Kulesskiy E, Paveliev M, Rivera C, Rauvala H, and Saarma M.(2011) Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin and artemin. J. Cell Biol., 192(1):153-169. (IF=9.58, NC=1). Discovery of syndecan -3 as the new receptor of GDNF, ARTN and NRTN and demonstrating its role GDNF-syndecan-3 signalling in neuronal migration Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, Demmers J, Peränen J, Pasterkamp RJ, van der Sluijs P, Hoogenraad CC, Akhmanova A. (2011) Rab6, Rab8, and MICAL3 Cooperate in Controlling Docking and Fusion of Exocytotic Carriers. Curr Biol. 21(11):967-974. (IF=10.8, NC=0) #Hellman M, Arumäe U, Yu L-y, Lindholm P, Peränen J, Saarma M* and Permi P*. Neurotrophic factor MANF has a unique mechanism to rescue apoptotic neurons. (2011) J Biol Chem, 286(4):2675-80. *equal contribution. (IF=6.9, NC=3). Solving the solution NMR structure of MANF and demonstrating that it can block Bax-triggered neuronal apoptosis Mijatovic J, Piltonen M, Alberton P, Männistö PT, Saarma M, Piepponen TP. (2011) Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals Neurobiology of Aging 32 ( 8), 1486-1494. (IF=6.3, NC=1) Piltonen M, Planken A, Leskelä O, Myöhänen TT, Hänninen AL, Auvinen P, Alitalo K, Andressoo JO, Saarma M, Männistö PT. (2011) Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo. Neuroscience 192, 550-563. (IF=3.8, NC=1). Voutilainen MH, Bäck S, Peränen J, Lindholm P, Raasmaja A, Männistö PT, Saarma M, Tuominen RK. Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease. (2011) Exp Neurol. 228(1): 99-108. (IF=4.1, NC=1) Airavaara M, Harvey BK, Voutilainen MK, Shen H, Chou J, Lindholm P, Lindahl M, Tuominen RK, Saarma M, Wang Y, Hoffer B. CDNF protects the nigrostriatal dopamine system and promotes recovery after MPTP treatment in mice. (2011). Cell Transplantation, in press. (IF=5.1, NC=0) List of patents and patent applications in 2008-2011 Granted patents
Patent applications
Kai Kaila: List of Publications (2008-2011) Articles in international refereed scientific journals Khirug S, Yamada J, Afzalov R, Voipio J, Khiroug L, Kaila K. 2008: GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1. J Neurosci. 28(18):4635-4639. Vanhatalo S, Kaila K. 2008: Generation of 'positive slow waves' in the preterm EEG: By the brain or by the EEG setup? Clin Neurophysiol. 119:1453-1454. Schuchmann S, Tolner EA, Marshall P, Vanhatalo S, Kaila K. 2008: Pronounced increase in breathing rate in the "hair dryer model" of experimental febrile seizures. Epilepsia 49:926-928. Colonnese MT, Phillips MA, Constantine-Paton M, Kaila K, Jasanoff A 2008: Development of hemodynamic responses and functional connectivity in rat somatosensory cortex. Nat Neurosci.11:72-79. Shulga A, Thomas-Crusells J, Sigl T, Blaesse A, Mestres P, Meyer M, Yan Q, Kaila K, Saarma M, Rivera C, Giehl KM. (2008) Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons. J Neurosci 28:6996-7005. Papp E, Rivera C, Kaila K, Freund TF. 2008: Relationship between neuronal vulnerability and potassium-chloride cotransporter 2 immunoreactivity in hippocampus following transient forebrain ischemia. Neuroscience 154:677-689. Hartmann AM, Blaesse P, Kranz T, Wenz M, Schindler J, Kaila K, Friauf E, Nothwang HG. 2009: Opposite effect of membrane raft perturbation on transport activity of KCC2 and NKCC1. J Neurochem. 111:321-331. Sipilä ST, Huttu K, Yamada J, Afzalov R, Voipio J, Blaesse P, Kaila K 2009: Compensatory Enhancement of Intrinsic Spiking upon NKCC1 Disruption in Neonatal Hippocampus. J Neurosci 29:6982-6988. Blaesse P, Airaksinen MS, Rivera C, Kaila K 2009: Cation-chloride cotransporters and neuronal function. Neuron 61:820-838. (invited review, invitation to KK) Schuchmann S, Vanhatalo S, Kaila K 2009: Neurobiological and physiological mechanisms of fever-related epileptiform syndromes. Review. Brain and Development 31:378-382. Ruusuvuori E, Kirilkin I, Pandya N, Kaila K. 2010: Spontaneous network events driven by depolarizing GABA action in neonatal hippocampal slices are not attributable to deficient mitochondrial energy metabolism. J Neurosci. 30:15638-15642. Khirug S, Ahmad F, Puskarjov M, Afzalov R, Kaila K, Blaesse P 2010: A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus. J Neurosci. 30:12028-12035. Horn Z, Ringstedt T, Blaesse P, Kaila K, Herlenius E 2010: Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism. Eur J Neurosci 31:2142-2155. Carta F, Temperini C, Innocenti A, Scozzafava A, Kaila K, Supuran CT 2010: Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem 53:5511-5522. Viitanen T, Ruusuvuori E, Kaila K, Voipio J 2010: The K+-Cl- Cotransporter KCC2 promotes GABAergic Excitation in the Mature Rat Hippocampus. J Physiol. 2010 588(Pt 9):1527-1540. Asiedu M, Ossipov MH, Kaila K, Price TJ 2010: Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. Pain 148:302-308. Schuchmann S, Hauck S, Henning S, Grüters-Kieslich A, Vanhatalo S, Schmitz D, Kaila K. 2011: Respiratory alkalosis in children with febrile seizures. Epilepsia. 52: 1949-1955. Helmy MM, Tolner EA, Vanhatalo S, Voipio J, Kaila K. 2011: Brain alkalosis causes birth asphyxia seizures, suggesting therapeutic strategy. Ann Neurol. 69:493-500. Ahmad F, Coleman SK, Kaila K, Blaesse P. 2011: Cold-adapted protease enables quantitation of surface proteins in the absence of membrane trafficking. BioTechniques 50:255-257. Tolner EA, Hochman DW, Hassinen P, Otáhal J, Gaily E, Haglund MM, Kubová H, Schuchmann S, Vanhatalo S, Kaila K 2011: Five percent CO2 is a potent, fast-acting inhalation anticonvulsant. Epilepsia 52:104-114. Kaila K 2011: A prestabilized harmony. Neuron 71:201-202. Stjerna S, Voipio J, Metsäranta M, Kaila K, Vanhatalo S: Preterm EEG: A Multimodal Neurophysiological Protocol (video article, JOVE, in press) Fiumelli H, Briner A, Puskarjov M, Blaesse P, Belem BJT, Dayer AG, Kaila K, Martin J-L, Vutskits L: An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo (Cerebral Cortex; in press) Articles in International Refereed Compilation Works Sipilä ST, Kaila K 2008: GABAergic Control of CA3-driven network events in the developing hippocampus. In: Inhibitory Regulation of Excitatory Neurotransmission, Ed. Mark Darlison, Springer-Verlag, Heidelberg. Results Probl Cell Differ. 44:99-121. Vanhatalo S, Voipio J, Kaila K 2011: Infraslow EEG activity. In: Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, 6th edition, Eds. Niedermeyer E, Lopes da Silva F, pp. 741-747. Baltimore-Munich: Williams & Wilkins. Vanhatalo S, Kaila K 2010: Emergence of spontaneous and evoked EEG activity in the human brain. In: The Newborn Brain: Neuroscience and Clinical Applications (2nd Ed). Pp 229-244. Eds. Lagercrantz H, Hanson M., Evrard P, Rod C. Cambridge University Press: Cambridge Sipilä ST, Kaila K 2010: GABAergic transmission and neuronal network events during hippocampal development. In: Developmental Plasticity of Inhibitory Circuitry. Ed. Pallas, S. Springer. Sipilä ST, Blaesse P, Kaila K 2010: Development of GABAergic signaling: from molecules to emerging networks. In: Oxford Handbook of Developmental Behavioral Neuroscience. Eds: Blumberg MS, Freeman JH, Robinson SR, pp 108-769.Oxford University Press. Miles R, Blaesse P, Huberfeld G, Wittner L, Kaila K: Chloride homeostasis and GABA signaling in temporal lobe epilepsy, In: Jasper's Basic Mechanisms of the Epilepsies, 4th edition. Eds. Noebels, Avoli, Rogawski, Olsen, Delgado-Escueta, (Oxford University Press, in press) Heikki Rauvala: List of publications (2008-2011) A. Articles in international refereed scientific journals Ilmakunnas, M., Tukiainen, E.M., Rouhiainen, A., Rauvala, H., Arola, J., Nordin, A., Mäkisalo, H., Höckerstedt, K., and Isoniemi, H. (2008). High mobility group box 1 protein as a marker of hepatocellular injury in human liver transplantation. Liver Transpl. 14(10): 1517-25. Paveliev, M., Hienola, A., Jokitalo, E., Planken, A., Bespalov, M.M., Rauvala, H., and Saarma, M. (2008). Sensory neurons from N-syndecan-deficient mice are defective in survival. NeuroReport 19(14): 1397-1400. Tian, L., Lappalainen, J., Autero, M., Hänninen, S., Rauvala, H., and Gahmberg, C.G. (2008). Shedded neuronal ICAM-5 suppresses T cell activation. Blood 111(7): 3615-3625. Imai, S., Heino, T.J., Hienola, A., Kurata, K., Büki, K., Matsusue, Y., Väänänen, H.K., and Rauvala, H. (2009). Osteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loading. Bone 44(5): 785-794. Lindström, O., Tukiainen, E., Kylänpää, L., Mentula, P., Rouhiainen, A., Puolakkainen, P., Rauvala, H., and Repo, H. (2009). Circulating levels of a soluble form of receptor for advanced glycation end products, and high-mobility group box chromosomal protein 1 in patients with acute pancreatitis. Pancreas 38(8): e215-20. Piltonen, M., Bespalov, M.M., Ervasti, D., Matilainen, T., Sidorova, Y.A., Rauvala, H., Saarma, M., and Männistö, P.T. (2009). Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons. Exp. Neurol. 219(2): 499-506. Tian, L., Rauvala, H., and Gahmberg, C.G. (2009). Neuronal regulation of immune responses in the central nervous system. Trends Immunol. 30: 91-99. Rauvala, H., and Rouhiainen, A. (2010). Physiological and pathophysiological outcomes of the interactions of HMGB1 with cell surface receptors. Biochim. Biophys. Acta 1799: 164-170. Tammimäki, A., Käenmäki, M., Kambur, O., Kulesskaya, N., Keisala, T., Karvonen, E., García-Horsman, J.A., Rauvala, H., and Männistö, P.T. (2010). Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice. Psychopharmacology (Berl). 211: 389-401. Tian, L., and Rauvala, H. (2010). Immune functions of glia and neurons in the central nervous system. Curr. Immunol. Rev. 6: 160-166. Andersson, U., and Rauvala, H. (2011). Introduction: HMGB1 in inflammation and innate immunity. J. Int. Med. 270: 296-300. Bespalov, M.M., Sidorova, Y.A., Tumova, S., Ahonen-Bishopp, A., Magalhaes, A.C., Kulesskiy, E., Paveliev, M., Rivera, C., Rauvala, H., and Saarma, M. (2011). Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin. J. Cell Biol. 192: 153-169. Kulesskaya, N., Rauvala, H., and Võikar V. (2011). Evaluation of social and physical enrichment in modulation of behavioural phenotype in C57BL/6J female mice. PLoS ONE 6: e24755 (10.1371/journal.pone.0024755). Roussel, B.D., Mysiorek, C., Rouhiainen, A., Jullienne, A., Parcq, J., Hommet, Y., Culot, M., Berezowski, V., Cecchelli, R., Rauvala, H. Vivien, D., and Ali, C. (2011). HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator. J. Cell Sci. 124: 2070-2076. Zhao, X., Kuja-Panula, J., Rouhiainen, A., Chen, Y.C., Panula, P., and Rauvala, H. (2011). High Mobility Group Box-1 (HMGB1; Amphoterin) is required for zebrafish brain development. J. Biol. Chem. (neurobiology) 286: 23200-23213. Peltola, M., Kuja-Panula, J., Lauri ,S., Taira, T., and Rauvala, H. (2011). AMIGO is an auxiliary subunit of the Kv2.1 potassium channel. EMBO Rep. 12: 1293-1299. Kajander, T., Kuja-Panula, J., Rauvala, H., and Goldman, A. (2011). Crystal structure and role of glycans and dimerisation in folding of neuronal leucine rich repeat protein AMIGO-1. J. Mol. Biol. 413: 1001-1015. Articles in International Refereed Compilation Works Rouhiainen, A., Kuja-Panula, J., Tumova, S., and Rauvala, H. RAGE-mediated cell signalling. Methods in molecular biology (an invited review), in press. Patent applications
Eero Castrén: List of Publications (2008-2011) Articles in international refereed scientific journals Maya Vetencourt JF, Sale A, Viegi A, Baroncelli L., De Pasquale R, O’Leary OF, Castrén E. and Maffei L. The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science, 320, 385-388, 2008. Onishchenko N., Karpova N., Sabri F., Castrén E., and Ceccatelli S. Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury. J Neurochem. 106: 1378-87, 2008. Rantamäki T., Castrén E. Targeting TrkB neurotrophin receptor to treat depression. Exp. Opin. Ther. Targets 12: 705-715, 2008. Greco D., Somervuo P., Raitila T., Nitsch L., Castrén E, Auvinen P. Connectome of human tissues based on meta-analysis of gene expression data. PLoS ONE 3(4): e1880. doi:10.1371/journal.pone.0001880, 2008. Martin M.G., Perga S, Trovò L., Rasola A., Holm, P., Rantamäki T., Harkany T., Castrén E., Chiara F, and Dotti, C.G. Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro. Mol. Biol. Cell 19:2101-2112, 2008. Sallert M., Rantamäki T., Vesikansa A., Anthoni H., Harju K., Yli-Kauhaluoma J., Taira T., Castrén E., Lauri S.E. BDNF controls activity-dependent maturation of CA1 synapses by down regulating tonic activation of presynaptic kainate receptors. J.Neurosci. 29:11294 –11303, 2009. Wu, X, Castrén, E. Co-treatment with diazepam prevents the effects of fluoxetine on hippocampal neurogenesis. Biol. Psychiatry 66: 5-8, 2009. O’Leary O.F., Wu X, Castrén E. Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of ovariectomized rats and mice. Psychoneuroendocrinology, 34: 367-381, 2009. Karpova N., Jesse Lindholm J., Pruunsild P., Timmusk, T. and Castrén E., Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult mice. Eur. Neuropsychopharmacology 19: 97-108, 2009. Tervonen T.A., Louhivuori V., Sun X, Hokkanen M.-E., Kratochwil C.F., Zebryk P., Castrén E. and Castrén M.L. Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome. Neurobiol Dis. 33: 250-9, 2009. Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia. Massinen S., Kristiina Tammimies K.,Tapia-Páez I., Matsson H., Hokkanen M.-E., Söderberg O., Landegren U., Castrén E., Gustafsson J.-Å., Treuter E. and Kere J. Hum. Mol. Genet. 18: 2802-12, 2009. Karpova N.N, Rantamäki T., Di Lieto A., Lindemann L., Hoener M.C. and Castrén E. Darkness induces repressive chromatin remodeling at the BDNF gene in the hippocampus and visual cortex. Cell. Mol. Neurobiol. 30: 1117-23, 2010. Gyárfás T., Knuuttila J., Lindholm P., Rantamäki T. and Castrén E. Regulation of Brain-Derived Neurotrophic Factor (BDNF) and Cerebral Dopamine Neurotrophic Factor (CDNF) by Anti-Parkinsonian Drug Therapy In Vivo. Cell. Mol. Neurobiol. 30: 361-368, 2010. Castrén E. and Rantamäki T. The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity. Dev. Neurobiol. 70: 289-97, 2010. Castrén E., Rantamäki T. Role of Brain-Derived Neurotrophic Factor in the Etiology of Depression: Implications for Pharmacological Treatment. CNS Drugs 24: 1-7, 2010. Spulber S., Rantamäki T., Nikkilä O., Castrén E., Weihe P., Grandjean P., Ceccatelli S. Effects of maternal smoking and exposure to methylmercury on Brain-Derived Neurotrophic Factor (BDNF) concentrations in cord serum. Toxicological Sciences 117:263-269, 2010. Rantamäki T., Vesa L., Antila H., Di Lieto A., Tammela P., Schmitt A., Lesch K.-P., Rios M. and Castrén E. Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS One 6 (6): e20567, 2011. Lindholm J.S.O., Autio H., Vesa L.K., Antila H., Lindemann L., Hoener M.C., Skolnick P., Rantamäki T., Castrén E. The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf+/- heterozygous null mice. Neuropharmacology 61: 1291-1296, 2011. Autio H., Mätlik K., Rantamäki T., Lindemann L., Hoener M.C., Chao M., Arumäe U. and Castrén E. Acetylcholine esterase inhibitors rapidly activate Trk neurotrophin receptors in mouse hippocampus. Neuropharmacology 62: 391-397, 2011. Massinen S., Hokkanen M.-E., Matsson H., Tammimies K., Tapia-Páez I., Dahlström-Heuser V., Kuja-Panula J., Burghoorn J., Jeppsson K.E., Swoboda P., Peyrard-Janvid M., Toftgård R., Castrén E.* and Kere J. Increased expression of dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. PLoS One, 6(6):e20580, 2011. (*corresponding author). Maya Vetencourt J.F., Tiraboschi E. Spolidoro M., Castrén E., Maffei L. Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity. Eur J Neurosci. 33: 49-57, 2011. Kas M.J.H., Krishnan V, Gould T.D., Collier D.A., Olivier B., Klaus-Peter Lesch K.-P., Domenici E., Fuchs E., Gross C. and Castrén E. Advances in Multidisciplinary and Cross-species Approaches to Examine the Neurobiology of Psychiatric Disorders. Eur. Neuropsychopharmacol. 21: 532-544, 2011. Heinrich C., Lahteinen S, Suzuki F., Laharie A.-M., Huber S., Häussler U., Haas C., Larmet Y., Castrén E. and Depaulis A. Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of Mesial Temporal Lobe Epilepsy. Neurobiology of Disease 42: 35-47, 2011. Louhivuori V., Vicario A., Uutela M., Rantamäki T., Louhivuori L.M., Castrén E., Tongiorgi E., Åkerman K.E. and Castrén M.L. BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse. Neurobiology of Disease 41: 469-80, 2011. Razzoli M., Domenici E., Carboni L., Rantamaki T., Jesse Lindholm J., Castrén E., and Arban R. A role for BDNF/TrkB signaling in behavioral and physiological consequences of social defeat stress. Genes Brain Behavior. 10:424-33, 2011. Branchi, I. Karpova N.N., D’Andrea I., Castrén E, Alleva E. Epigenetic modifications induced by early enrichment are associated with changes in timing of induction of BDNF expression. Neuroscience Lett. 495: 168–172, 2011. Kivinummi T., Kaste K., Rantamäki T., Castrén E., Ahtee L. Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice. Neurosci. Lett. 491, 108–112, 2011. Karpova N.N., Pickenhagen A., Lindholm J., Tiraboschi E., Kulesskaya N., Ágústsdóttir A., Antila H., Popova D., Akamine Y., Sullivan R., Hen R., Drew L.J. and Castrén E. Fear Erasure in Mouse Requres Synergy Between Antidepressant Drug Treatment and Exposure Therapy. Science, in press. Kemppainen S., Rantamäki T., Jerónimo-Santos A., Lavasseur G., Autio H., Karpova N., Kärkkäinen E., Stavén S., Miranda H.V., Outeiro T.F., Diógenes, M.J., Laroche S., Davis S., Sebastião A.M., Castrén E., Tanila H. Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiology of Aging, in press. Articles in International Refereed Compilation Works Castrén E. Neurotrophins and Psychiatric disorders. In: Neurotrophic Factors, Handbook of Experimental Pharmacology, Eds. Lewin G. and Carter B. Springer, 2012, submitted. Onishchenko N., Karpova N.N., Castrén E. Epigenetics of environmental contaminants. In: Methylmercury and Neurotoxicity. Eds. Aschner M., Ceccatelli S., Current Topics in Neurotoxicity, Springer Science, in press. Castrén E., Maya Vetencourt J.F.: Neurotrophins as regulators of visual cortical plasticity. In: Cerebral Plasticity, Eds: L.M. Chalupa, N. Berardi, M. Caleo, L. Galli-Resta, T. Pizzorusso, The MIT Press, Cambridge MA, pp. 343-354, 2011. O’Leary O. F., Castrén E. Neurotrophic Factors and Antidepressant Action: Recent Advances. In: Depression: From Psychopathology to Pharmacotherapy. Mod Trends Pharmacopsychiatry, Cryan JF, Leonard BE (eds):. Basel, Karger, 2010, vol 27, pp 199–223. Castrén E. and Rantamäki T. Neurotrophins in depression and antidepressant effects. In: Growth factors and psychiatric disorders. Novartis Foundation Symposium 289, pp. 43-59, 2008. Patents, patent applications and Invention disclosures. Castrén Eero, Maffei Lamberto, Maya Vetencourt Jose Fernando, inventors. ”A method of treating amblyopia”. PCT Patent application WO2009004114A1, filed 280608. Castrén Eero, Maffei Lamberto, Maya Vetencourt Jose Fernando, inventors. ”A method of treating amblyopia”. US Patent application, filed 221208 Invention disclosures A method to assay for the activation of trkB neurotrophin receptors. Invention disclosure to the University of Helsinki 9.7.2008 p75 neurotrophin receptor cleavage reporter cell lines N2A275 and N2A276. Invention disclosure to the University of Helsinki 23.12.2010 Dearcription of a sensitizer of TrkB neurotrophin receptor. Invention disclosure to the University of Helsinki 1.2.2011. In situ phospho-TrkB ELISA (enzyme-linked immunosorbent assay) Invention disclosure to the University of Helsinki 1.2.2011.
Matti S. Airaksinen: List of publications (2008-2011) Articles in international refereed scientific journals Riekki R, Pavlov I, Tornberg J, Lauri S, Airaksinen MS and Taira T (2008) Altered synaptic dynamics but normal long-term plasticity in mice lacking hyperpolarizing GABA-AR-mediated inhibition. J. Neurophysiol. 99(6):3075-89. Markkanen M, Uvarov P, and Airaksinen MS (2008) Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K-Cl cotransporter KCC2. Brain Res. 1236: 8–15. Linhoff MW, Laurén J, Cassidy RM, Dobie FA, Nygaard HB, Airaksinen MS, Strittmatter SM, and Craig AM (2009). An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 61:734-749. Uvarov P, Ludwig A, Markkanen M, Soni S, Hübner CA, Rivera C, Airaksinen MS (2009). Coexpression of neuronal K-Cl cotransporter KCC2 isoforms in neonatal brain J. Biol. Chem. 284(20):13696-704. Blaesse P, Airaksinen MS, Rivera C, and Kaila, K. (2009) Cation-chloride cotransporters and neuronal function. Neuron 61:820-838. (review) Ludwig A*, Uvarov P*, Soni S, Thomas-Crusells J, Airaksinen MS and Rivera C (2011) Egr4 mediates BDNF induction of KCC2 transcription. J. Neurosci. 31(2):644-9 (* equal contribution) Uvarov P, Llano O, Ludwig A, Airaksinen MS, and Rivera C (2011) Multiple roles of KCC2 in the developing brain. In P. Rakic and J. Rubenstein (eds.): Comprehensive Developmental Neuroscience. Elsevier. (review, in press) Ludwig A*, Uvarov P*, Pellegrino C, Saarma M, Airaksinen MS and Rivera C (2011) Neurturin evokes MAPK-dependent up-regulation of Egr4 and KCC2 in developing neurons. Neural Plast. 2011:641248. (* equal contribution) Urmas Arumäe: List of publications (2008-2011) Articles in international refereed scientific journals Yu LY, Arumäe U (2008) Survival assay of transiently transfected dopaminergic neurons. J Neurosci Methods 169:8-15. Yu LY, Saarma M, Arumäe U (2008) Death receptors and caspases but not mitochondria are activated in the GDNF- or BDNF-deprived dopaminergic neurons. J Neurosci 28:7467-7475. Sidorova YA, Mätlik K, Paveliev M, Lindahl M, Piranen E, Milbrandt J, Arumäe U, Saarma M, Bespalov MM (2010) Persephin signaling through GFRalpha1: The potential for the treatment of Parkinson's disease. Mol Cell Neurosci 44:223-232. Hellman M, Arumäe U, Yu LY, Lindholm P, Peränen J, Saarma M, Permi P (2011) Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons. J Biol Chem 286:2675-2680 (first two authors contributed equally). Autio H, Mätlik K, Rantamäki T, Lindemann L, Hoener MC, Chao M, Arumäe U, Castrén, E. (2011)(2011) Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus. Neuropharmacology, 61:1291-6 Shulga A, Magalhaes A, Autio H, Plantman S, Di Lieto A, Nykjaer A, Carlstedt T, Risling M, Arumäe U, Castren E, Rivera C. The loop diuretic bumetanide blocks post-traumatic p75NTR upregulation and rescues injured neurons. J. Neurosci., in press Jakobson M, Lintulahti A, Arumäe, U. mRNA for N-Bak, a neuron-specific BH3-only splice isoform of Bak, escapes nonsense-mediated decay and is translationally repressed in the neurons. Cell Death Dis, in press Patents 2008-2011 Arumäe, U, Yu, L.Y., Saarma, M. Method of screening cell death modulators. US Patent 7642047. Application number 10/543651. Published 01.05.2010. Arumäe, U, Saarma, M., Runeberg-Roos, P. MANF/CDNF peptides. Patent FI20115870. Filed 5.9.2011. Claudio Rivera: List of publications (2008-2011) Shulga A, Thomas-Crusells J, Sigl T, Blaesse A, Mestres P, Meyer M, Yan Q, Kaila K, Saarma M, Rivera C, Giehl KM. (2008) Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons. J Neurosci. 28:6996-7005 Cai C, Li H, Kangasniemi A, Pihlajamaa T, Von Ossowski L, Kerkelä K, Schulz S, Rivera C, Keinänen K. (2008) Somatostatin receptor subtype 1 is a postsynaptic density-95/discs large/zona occludens-1 ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics. Neuroscience 157:833-43 Papp E, Rivera C, Kaila K, Freund TF (2008) Relationship between neuronal vulnerability and potassium-chloride cotransporter 2 immunoreactivity in hippocampus following transient forebrain ischemia. Neuroscience. 154:677-89. Coleman, S., Möykkynen T., Jouppila, A., Koskelainen, S., Rivera C., Korpi, E. and Keinänen K. (2009) Agonist Occupancy is Essential for Forward Trafficking of AMPA Receptors” J Neurosci. 29:303-12. Hotulainen P, Llano O, Smirnov S, Tanhuanpää K, Faix J, Rivera C, Lappalainen P. (2009) Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis. J Cell Biol. 185:323-39. Uvarov P, Ludwig A, Markkanen M, Soni S, Hübner CA, Rivera C, Airaksinen MS. (2009) Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain. J Biol Chem. 284:13696-704. Blaesse P, Airaksinen MS, Rivera C, Kaila K. (2009) Cation-chloride cotransporters and neuronal function. Neuron 61:820-38. Bespalov M, Sidorova Y, Tumova S, Ahonen-Bishopp A, Magalhães A, Kulesskiy E, Paveliev M, Rivera C, Rauvala H and Saarma M. (2010) Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin and artemin. J Cell Biol. 192(1):153-69. Ludwig A, Uvarov P, Soni S, Thomas-Crusells J, Airaksinen M and Rivera C (2011) Egr4 mediates BDNF induction of KCC2 transcription. J. Neurosci. 12;31(2):644-9. Ludwig A, Uvarov P, Pellegrino C, Thomas-Crusells J, Schuchmann S, Saarma M, Airaksinen MS, Rivera C. (2011) Neurturin evokes MAPK-dependent upregulation of Egr4 and KCC2 in developing neurons. Neural Plast. 2011:1-8. Shulga A, Magalhães A, Autio H, di Lieto A, Nykjær A, Arumäe U, Castrén C and Rivera C. (2012) The loop diuretic bumetanide blocks post-traumatic p75NTR up-regulation and rescues injured neurons J. Neurosci.in press (accepted 2011) Articles in International Refereed Compilation Works Rivera C. Ion Transport . In: encyclopaedia of neuroscience. Binder, Marc D.; Hirokawa, Nobutaka; Windhorst, Uwe (Eds.) (2009) Uvarov P., Ludwig A., Airaksinen M. and Rivera C. Multiple roles of KCC2 in the developing brain. In: Comprehensive Developmental Neuroscience. Rakic, Pasko; Rubenstein, John (Eds.) (2012) |